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PUMA: A Breakthrough in CRISPR-Cas12 for RNA Biomarker Detection

CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics.

17 Jul 2024

Liver-on-Chips: Innovations, Applications, and Challenges in Drug Development

The development and application of liver-on-chips and the factors preventing its widespread use in drug discovery.

12 Jul 2024

Retron-Based Tool Enables Multi-Site DNA Editing

Genome editing has become a widely adopted technology to modify DNA in cells, allowing scientists to study diseases in the lab and develop therapies that repair disease-causing mutations.

10 Jul 2024

Unveiling the Power of mRNA and LNPs in Modern Medicine

Consider a situation in which an expert hacker has to upload vital software to update a central server and stop a potentially fatal virus from causing havoc on a sizable computer network.

10 Jul 2024

Mice Studies Shed Light on Serotonin and Memory

Memory regulation in humans and animal models is regulated by the serotonin 2C receptor in the brain, according to research from Baylor College of Medicine, the University of Cambridge in the United Kingdom, and affiliated institutions.

1 Jul 2024

New High-Throughput Platform for Rapid Evaluation of Plant-Derived Molecules

Plants are powerhouses of molecular manufacturing. Over the eons, they have evolved to produce a plethora of small molecules -; some are beneficial and valuable to humans, others can be deadly.

28 Jun 2024

Small Molecule Restores TERT Levels to Combat Aging-Related Decline

Researchers at The University of Texas MD Anderson Cancer Center have demonstrated that therapeutically restoring 'youthful' levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical models.

24 Jun 2024

Australian Researchers Introduce Groundbreaking AI Tool for Early Stage Drug Discovery

Australian researchers, led by Monash University, have invented a new artificial intelligence (AI) tool which is poised to reshape virtual screening in early stage drug discovery and enhance scientists’ ability to identify potential new medicines.

22 Jun 2024

Study Provides a New Way to Measure Healthy Microbiomes in the Gut and Soil

Focusing on four common diseases – diabetes, heart disease, depression and bowel cancer – new Flinders University research provides insights into the importance of a healthy microbiome balance in the human gut and in the environment.

22 Jun 2024

Boron-Mediated Photocycloaddition: Expanding Quinoline's Potential for Drug Development

An innovative synthesis strategy opened up the way to 2D/3D fused frameworks using inexpensive quinolines as feedstock, report scientists from Tokyo Tech.

21 Jun 2024

Enzymes Replace Cyanide in Eco-Friendly Nitrile Synthesis

If the household cleaner emits a lemon-like odor, it may be due to a nitrile called citronellyl nitrile. Chemical-resistant gloves, superglue, and active pharmaceutical ingredients are all made with these adaptable chemical nitrile groups.

19 Jun 2024

New Study Reveals Microbial Role in Soil Carbon Emissions

When soil microbes eat plant matter, the digested food follows one of two pathways. Either the microbe uses the food to build its own body, or it respires its meal as carbon dioxide (CO2) into the atmosphere.

12 Jun 2024

CARA Benchmark Set to Revolutionize Data-Driven Drug Discovery Methods

A compound activity prediction benchmark they curated for real-world, practical applications called Compound Activity benchmark for Real-world Applications (CARA).

11 Jun 2024

Study Highlights Key Protein-Lipid Interactions in Mitochondrial Energy Production

By studying mutations in yeast and human cells, Johns Hopkins Medicine scientists say they have found that biochemical bonds between fats and proteins in the mitochondrion, the cell's powerhouse, play a crucial role in how our cells produce energy.

10 Jun 2024

Neurons in the Visual System of Flies Exhibit Surprisingly Heterogeneous Wiring

Analysis of the connectome of Drosophila melanogaster provides new insights into how its visual system is organized / Research contribution by the FlyWire Consortium

4 Jun 2024

Engineered DNA PROTAC Shows Promise for p53-R175H Mutant Cancers

A synthetic bicomponent compound specifically targets and eliminates a mutant protein associated with multiple forms of cancer.

30 May 2024

Study Reveals How tRNA Modification Influences Malaria Drug Resistance

Researchers from the Antimicrobial Resistance (AMR) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, in collaboration with Massachusetts Institute of Technology (MIT), Columbia University Irving Medical Center (CUIMC), and Nanyang Technological University, Singapore (NTU Singapore), have discovered a link between malaria parasites’ ability to develop resistance to antimalarial drugs – specifically artemisinin (ART) – through a cellular process called transfer Ribonucleic acid (tRNA) modification.

20 May 2024

Breakthrough in Natural Vanillin Production Using Engineered Enzyme

Vanilla extract is one of the most widely used flavoring compounds in food products and cosmetics.

17 May 2024

Discovery of Novel Adrenal Cell Type Linked to Monogamy in Oldfield Mice

What makes the oldfield mouse steadfastly monogamous throughout its life while its closest rodent relatives are promiscuous? The answer may be a previously unknown hormone-generating cell, according to a new study published online today in Nature from scientists at Columbia's Zuckerman Institute.

16 May 2024

Researchers Identify Natural Compounds for Parasitic Worm Treatment

An international team led by researchers at the University of Toronto has found a family of natural compounds with potential as new and more effective treatments for parasitic worms.

9 May 2024