Cytoskeleton News and Research

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FAM110A's Dual Role: Orchestrating Microtubule-Actin Interactions in Mitosis

An international research collaboration, led by Prof. Dr. Robert Grosse (Centre for Integrative Biological Signalling Studies and Institute of Clinical and Experimental Pharmacology and Toxicology, University of Freiburg), Dr. Libor Macurek (Institute of Molecular Genetics, Czech Academy of Sciences, Prague) and Dr. Zdenek Lansky (Institute of Biotechnology, Czech Academy of Sciences, Prague) has uncovered a new mechanism of the crosstalk between microtubules and actin cytoskeleton during cell division and revealed unique characteristics of the previously unexplored protein FAM110A.

17 Jul 2024

Mapping Gene Targets of HNF4A and HNF1A in Human Pancreatic Beta Cells and Liver Cells

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells.

26 Jun 2024

3D Cell Cultures Improve Drug Screening Accuracy but Show Lower Efficacy for Anti-Cancer Drugs

The existing knowledge on monolayers and spheroid-based cell cultures, including the constituent compounds, and the difference in efficacy during drug screening, especially for anti-cancer drugs targeting cytoskeletal dynamics and cell cycles.

21 Jun 2024

Researchers Recreate Chemically Regulated Actin Polymerization to Study Membrane Dynamics

A synthetic platform that uses dimerization modules consisting of chemical proteins to precisely control the polymerization of actin and demonstrate symmetry breaking.

19 Jun 2024

Exploring the Evolution of Mitosis: Lessons from Close Relatives of Fungi and Animals

Cell division is one of the most fundamental processes of life. From bacteria to blue whales, every living being on Earth relies on cell division for growth, reproduction, and species survival.

23 May 2024

Study Reveals Dual Contractility Modes in Cancer Cell Invasion

Understanding how cancerous cells spread from a primary tumor is important for any number of reasons, including determining the aggressiveness of the disease itself.

8 May 2024

Fruit Fly Model Unveils Hidden Mechanisms of Organ Development

A new computational model simulating fruit fly wing development has enabled researchers to identify previously hidden mechanisms behind organ generation.

8 May 2024

Visualizing the Molecular Interaction of Formins with Actin Filaments

Actin is a highly abundant protein that controls the shape and movement of all our cells. Actin achieves this by assembling into filaments, one actin molecule at a time.

17 Apr 2024

Scientists Harness Cellular Scaffolding for New Bio-Inspired Technologies

Princeton researchers have learned to harness the gossamer scaffolding that maintains the structure of living cells and used it to develop a nanotechnology platform.

27 Jan 2024

Immune Cell Movement Influenced By Water and Ion Influx

Scientists at the Francis Crick Institute, in collaboration with Imperial College London, King’s College London, and the University of Cambridge, have demonstrated that the influx of water and ions into immune cells enables them to navigate to specific locations in the body.

7 Dec 2023

New Method Allows Scientists to Observe Multiple Signals in Living Cells

Living cells are bombarded with many kinds of incoming molecular signal that influence their behavior.

29 Nov 2023

The Adaptable World of Dendritic Cells in Immunity

Dendritic cells play a pivotal role within the mammalian immune system, being distributed throughout the human body.

31 Oct 2023

Role of Chloroplasts’ Dual Function From Photosynthesis to Immune Defense

For a long period, scientists have been aware of chloroplasts' role in converting solar energy into plant food.

26 Oct 2023

Study Offers New Understanding of How Stem Cells Divide in Plants

Every time a stem cell divides, one daughter cell remains a stem cell while the other takes off on its own developmental journey.

7 Jul 2023

Key Atomic Structures of the Actin Filament Revealed Through Cryo-EM

Actin filaments -; protein structures critical to living movement from single cells to animals -; have long been known to have polarity associated with their physical characteristics, with growing "barbed" and shrinking "pointed" ends.

9 Jun 2023

High-quality genome of a deep-sea eel illuminates the molecular mechanisms of deep-sea adaptation

Recently, the research team led by Dr. Shunping He from the Institute of Deep Sea Science and Engineering, Chinese Academy of Sciences, published their research findings in the online version of SCIENCE CHINA Life Sciences.

28 Mar 2023

How specialized plant “train tracks” can be used to feed the expanding population

A new study will examine the possibility that specialized plant “train tracks” that transport chemicals within cells could help in feeding the world’s expanding population.

From The University of Warwick 23 Mar 2023

Describing the molecular basis behind the ultrafast contraction of Spirostomum

Antonie van Leeuwenhoek stated that a single-celled eukaryote (Vorticella) and its appealing ultrafast cell contraction was the first set of discoveries. This was told in his famous letter to the Royal Society dated October 9th, 1676.

23 Feb 2023

DZNE scientists discover major role of centrosome in neuronal migration

Researchers from the DZNE have solved an important puzzle in neurobiology: the wiring and the movement of nerve cells are interwoven, but separately controlled.

16 Feb 2023

Innovative cancer therapy options with new cell death mechanism

Researchers from The University of Texas MD Anderson Cancer Center have described a previously unrecognized type of cell death called disulfidptosis in a study that was published in Nature Cell Biology.

7 Feb 2023