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Molecular staple: The DNA repair mechanism impeding cancer treatment

Due to the continuous cellular activity, malfunctions frequently occur, making error-correcting systems crucial for cells. However, it serves the cancer cells’ best interests to cause errors when it comes to destroying them.

30 Jan 2023

Highly potent antibiotic candidate identified

One of the most promising new antibiotic candidates in decades is a powerful plant toxin that harbors a novel way of killing hazardous bacteria.

26 Jan 2023

Enhancing the efficacy of CRISPR/Cas9 and related methods

The effectiveness of molecular genetic techniques like CRISPR/Cas9 and related systems has been significantly improved, and their range of applications has been expanded, by researchers from the Department of Developmental Biology/Physiology at the Centre for Organismal Studies of Heidelberg University.

26 Jan 2023

Potential to rectify various disease-causing mutations enhanced by CRISPR-based enzymes

Designing genome editing strategies for each patient’s mutation would be impractical and expensive because many genetic diseases are induced by diverse mutations spread across an entire gene.

18 Jan 2023

Intracellular drug delivery using a novel nano transporter

The effectiveness of a novel nano molecule as a drug delivery system has been examined in a recent study by the University of Barcelona.

From University of Barcelona 13 Jan 2023

New solution to treat diseases caused by exaggerated inflammation

A recent study guided by the Instituto Gulbenkian de Ciência (IGC) shows how anticancer drugs reduce inflammation, establishing them as prospective sepsis treatments.

11 Jan 2023

Novel blood biomarker predicts a favorable response to CART cell therapy

A MedUni Vienna research group identified a particularly potent biomarker for clinical response to CAR-T cell therapy, establishing the conditions for the most effective use of this innovative therapy for lymphoma treatment.

11 Jan 2023

Major development in re-treatment with CAR T therapy

At the American Society of Hematology (ASH) Annual Meeting in 2022 (Abstract 2016), researchers from the Abramson Cancer Center at the University of Pennsylvania presented preliminary findings from an ongoing Phase I clinical trial demonstrating effective re-treatment with CAR T cell therapy for patients whose cancers relapsed after prior CAR T therapy.

12 Dec 2022

Predictive classifier identifies patients who can skip radiation therapy

According to the findings of a meta-analysis proposed at the San Antonio Breast Cancer Symposium held on December 6–10th, 2022, patients with invasive breast cancer who had low scores on an investigational gene molecular signature seemed to have similar rates of local recurrence regardless of whether they received adjuvant radiation therapy after breast-conserving surgery.

12 Dec 2022

Small fluorescent protein helps researchers to capture deeper, more precise biomedical images

Biomedical and genetic engineers at Duke University and the Albert Einstein College of Medicine have designed a small fluorescent protein that emits and absorbs light that penetrates deep into biological tissue.

7 Dec 2022

Gyros Protein Technologies adds Gyrolab® Biomarker Kits to expand range of ready-to-use kits and reagents

Gyros Protein Technologies AB today introduced Gyrolab® Human Cytokine Kit Reagents, the first in a range of new biomarker kits.

From Gyros Protein Technologies AB 30 Nov 2022

Novel approach increases the protein production efficiency of synthetic mRNAs

A group of synthetic biologists at the Hong Kong University of Science and Technology (HKUST) recently figured out a way to improve the efficiency of synthetic mRNA protein production by up to tenfold.

24 Nov 2022

Expanding the CRISPR-based toolbox for extensive genome engineering

Researchers from North Carolina State University describe a variety of CRISPR-Cas systems-based molecular tools to rewrite, rather than just edit, significant portions of an organism’s DNA.

23 Nov 2022

Chemically attenuated live DNA virus vaccine prevents viral infection

Rutgers researchers have devised a new way to prevent viral infections: a live-attenuated, replication-defective DNA virus vaccine that utilizes the substance centanamycin to create an altered virus for vaccine development.

From Rutgers University 22 Nov 2022

The critical role of amino acid sensing pathways in driving colorectal cancer

A dietary modification may be essential to improving colon cancer treatment, according to research from the University of Michigan Rogel Cancer Center.

22 Nov 2022

CRISPR technology to improve the efficacy of immunotherapy

Using CRISPR technology for the first time, researchers have inserted genes that enable immune cells to concentrate their attack on cancer cells, potentially sparing healthy cells and boosting the effectiveness of immunotherapy.

14 Nov 2022

Understanding immune cell function to improve vaccine efficacy

The immune system’s capacity to remember defeated disease-causing germs and avoid recurrent infections is still poorly understood, but a new study published in Science Immunology fills in some gaps.

From Rutgers University 8 Nov 2022

Combating antibiotic-resistant bacteria with new drug

The overuse of antibiotics has forced microorganisms to evolve defenses against this kind of treatment. Antibiotic resistance is a problem that the WHO now views as one of the major hazards to human health.

8 Nov 2022

“Screen-first” approach mines microbes directly from the environment

The best method now available for researchers to isolate a specific microorganism with a given metabolic function from an environment is to collect a sample of cells, culture them, and then test them for the desired cell functions.

4 Nov 2022

Novel liposomal nanovaccines strongly activate cellular immunity

Cancer immunotherapies, such as immune checkpoint inhibition therapy, have been attracting attention in recent years as new methods for treating cancer.

2 Nov 2022