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Obesity Influenced by Genetic Predisposition is Associated With Lower Risk of Cardiovascular Disease

The risk of developing cardiovascular disease is lower in people with obesity who have a genetic predisposition for high BMI than people with obesity influenced mainly by environmental factors such as lifestyle, researchers from Karolinska Institutet report in eClinical Medicine.

6 Apr 2023

Microbial Composition of the Gut may Affect a Child's Susceptibility to ADHD

New research published in the Journal of Child Psychology and Psychiatry suggests that the microbial composition of the gut may affect a child's susceptibility to attention-deficit/hyperactivity disorder (ADHD).

6 Apr 2023

Poor Sleep Combined With High Genetic Susceptibility Results in Greater Asthma Risk

Poor quality sleep may bolster a person's genetic susceptibility to asthma, potentially doubling their risk of being diagnosed with the condition, suggests a large UK Biobank study, published in the open access journal BMJ Open Respiratory Research.

6 Apr 2023

Role of Engineered E. coli in Sending Therapeutic Nanobodies to the Gut

Numerous bacterium types have taken up residence in humans. Currently, research is concentrated on genetically modifying these bacteria to increase their inherent therapeutic qualities.

5 Apr 2023

Cellular Recycling Function in the Brain Slows Dramatically After Traumatic Brain Injury

Each year about 1.5 million people in the U.S. survive a traumatic brain injury due to a fall, car accident, or a sports injury, which can cause immediate and long-term disability.

5 Apr 2023

Potential Treatment Pathway for IBD Emerges from Microbe-Gut Signaling Study

Fresh insights into how our bodies interact with the microbes living in our guts suggest that a two-drug combination may offer a new way to treat inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.

4 Apr 2023

MET+LEU Cocktail Prevents Cellular Senescence and Disrupted Proteostasis Induced by Myotube Atrophy

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 6, entitled, "Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail."

3 Apr 2023

Newly Identified Rare Genetic Variants Could Point to One of the General Mechanisms Driving AMD

A study from the National Eye Institute (NEI) identified rare genetic variants that could point to one of the general mechanisms driving age-related macular degeneration (AMD), a common cause of vision loss in older adults.

3 Apr 2023

UConn Health scientists explain why Shigella bacteria can infect humans but not mice

Shigella bacteria can infect humans but not mice. In the March 29 issue of Nature, a team from UConn Health explains why. Their findings may explain the multifariousness of a key weapon of our immune system.

31 Mar 2023

New nanoparticles can deliver mRNA encoding CRISPR/Cas9 components to the lungs

Engineers at MIT and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins.

31 Mar 2023

Immune cells in human blood produce acetylcholine that regulates blood pressure and inflammation

Acetylcholine regulates blood flow, but the source of blood acetylcholine has been unclear. Now, researchers at Karolinska Institutet have discovered that certain T cells in human blood can produce acetylcholine, which may help regulate blood pressure and inflammation.

31 Mar 2023

Clearance of senescent cells by boosting anti-viral immune response

Aging, or senescent cells, which stop dividing but don't die, can accumulate in the body over the years and fuel chronic inflammation that contributes to conditions such as cancer and degenerative disorders.

31 Mar 2023

Rare genetic variants identified that point to MAC as a therapeutic target for age-related macular degeneration

A new study conducted at the National Eye Institute (NEI) has identified incredibly rare genetic variants that might uncover the mechanisms underlying the development of AMD.

31 Mar 2023

Novel inhibitor, hopeaphenol, blocks HIV expression

In the United States, around 1.2 million people are living with HIV as of 2022. Many of these people can now live productive, symptom-free lives thanks to antiretroviral therapies, but a solution that permanently removes HIV from an infected person’s body is still a long way off.

30 Mar 2023

New kind of smart bandage for monitoring and treatment of chronic wounds

Most of the time, when someone gets a cut, scrape, burn, or other wound, the body takes care of itself and heals on its own.

27 Mar 2023

Blunted inflammatory response in obese individuals responsible for susceptibility to severe COVID-19

Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists.

23 Mar 2023

Researchers discover a new intracellular "smoke detector"

Researchers at the Universities of Bonn and Singapore have discovered a new intracellular "smoke detector." The sensor warns of damage to the mitochondria - the microscopic power plants that supply the cell with energy.

22 Mar 2023

Blunted inflammatory response could make obese patients more susceptible to severe COVID-19

Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists.

21 Mar 2023

Uncovering the role of the third intracellular loop in the GPCR’s signaling mechanism

Over a one-third of FDA-approved drugs tend to function by targeting a G protein-coupled receptor, or so-called GPCR. The human body consists of over 800 kinds of GPCRs that offer cells with data concerning the external surrounding to calibrate responses.

20 Mar 2023

Study discovers the ability of certain blood immune cells to proliferate

The ability of a cell to divide, to proliferate, is essential for life and gives rise to the formation of complex organisms from a single cell.

20 Mar 2023

Inflammation News and Research

Obesity Influenced by Genetic Predisposition is Associated With Lower Risk of Cardiovascular Disease

Microbial Composition of the Gut may Affect a Child's Susceptibility to ADHD

Poor Sleep Combined With High Genetic Susceptibility Results in Greater Asthma Risk

Role of Engineered E. coli in Sending Therapeutic Nanobodies to the Gut

Cellular Recycling Function in the Brain Slows Dramatically After Traumatic Brain Injury

Potential Treatment Pathway for IBD Emerges from Microbe-Gut Signaling Study

MET+LEU Cocktail Prevents Cellular Senescence and Disrupted Proteostasis Induced by Myotube Atrophy

Newly Identified Rare Genetic Variants Could Point to One of the General Mechanisms Driving AMD

UConn Health scientists explain why Shigella bacteria can infect humans but not mice

New nanoparticles can deliver mRNA encoding CRISPR/Cas9 components to the lungs

Immune cells in human blood produce acetylcholine that regulates blood pressure and inflammation

Clearance of senescent cells by boosting anti-viral immune response

Rare genetic variants identified that point to MAC as a therapeutic target for age-related macular degeneration

Novel inhibitor, hopeaphenol, blocks HIV expression

New kind of smart bandage for monitoring and treatment of chronic wounds

Blunted inflammatory response in obese individuals responsible for susceptibility to severe COVID-19

Researchers discover a new intracellular "smoke detector"

Blunted inflammatory response could make obese patients more susceptible to severe COVID-19

Uncovering the role of the third intracellular loop in the GPCR’s signaling mechanism

Study discovers the ability of certain blood immune cells to proliferate

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