Lipids are a broad group of naturally-occurring molecules which includes fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The main biological functions of lipids include energy storage, as structural components of cell membranes, and as important signaling molecules.
In a recent study published in Nature Communications, researchers utilized a comprehensive multi-omics approach, integrating genomic, proteomic, and metabolomic data from a diverse cohort, to uncover detailed molecular interactions and identify distinct diabetes subgroups.
Modified nucleotides like m5C in saRNA enhance vaccine efficacy, stability, and reduce inflammation, offering a promising approach for SARS-CoV-2 protection.
Cancer cells seldom start off stealthy. Quite to the contrary, they announce their presence to the immune system by planting chemical red flags right on their membranes.
Researchers at the Institute for Integrated Cell-Material Sciences (WPI-iCeMS) at Kyoto University have discovered new information regarding how cells control the distribution of lipids in their cell membrane.
A study by the team of Prof. Kodi Ravichandran (VIB-UGent Center for Inflammation Research) and colleagues found that pyroptosis, a form of programmed cell death traditionally thought to be purely inflammatory, also plays a crucial role in promoting healing and tissue repair.
Scientists are working to create quicker, more quantitative, and more publicly available methods of seeing biomolecules in living cells to speed up biotechnology discoveries, such as the production of lifesaving drugs.
Most animals live in intimate relationships with bacteria. Some of these bacteria live inside the cells of their hosts, but only very few are able to live inside cell organelles (structures inside the cell, like organs in the body).
A common skin fungus, Malassezia globosa may invade deep tissues through the skin or by other means, then cause tumor growth, according to a new study.
The surprising discovery of a bacterium in a marine sponge from the Great Barrier Reef with striking similarity to Mycobacterium tuberculosis, the pathogen responsible for tuberculosis (TB), could unlock and inform future TB research and treatment strategies.
A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 14 on July 19, 2024, entitled, "Lipid accumulation drives cellular senescence in dopaminergic neurons."
Scientists at Nagoya University in Japan have made a significant breakthrough in treating lipid disorders.
The release of the new version of ISO 15189 (2022), introduced increased focus on risk stratification and mitigation for patients and laboratory stakeholders as well as more emphasis on quality control to improve accuracy and validity of results. Interference caused by hemolysis, icterus and lipemia is responsible for many rejected results and incorrect diagnosis. It is therefore of the upmost importance to accurately capture the presence of interfering substances in samples before quantitative analysis is carried out.
Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood.
Each cell in the body has its own unique delivery system that scientists are working on harnessing to move revolutionary biological drugs -; molecules like proteins, RNA and combinations of the two -; to specific diseased parts of the body.
Consider a situation in which an expert hacker has to upload vital software to update a central server and stop a potentially fatal virus from causing havoc on a sizable computer network.
A novel discovery platform has been created by a multidisciplinary research team to investigate the role of genes involved in metabolism, which is the culmination of all chemical reactions necessary for life.
Alzheimer's disease (AD), which affects millions of people globally, is still one of the most difficult and common neurodegenerative conditions.
A synthetic platform that uses dimerization modules consisting of chemical proteins to precisely control the polymerization of actin and demonstrate symmetry breaking.
A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a "hydrophobic" protein that loses its structure once removed from its normal location in the cell membrane.
By studying mutations in yeast and human cells, Johns Hopkins Medicine scientists say they have found that biochemical bonds between fats and proteins in the mitochondrion, the cell's powerhouse, play a crucial role in how our cells produce energy.
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