Lysosomes News and Research

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Newly discovered mechanism identified in the initial stages of Alzheimer's disease

Alzheimer's disease (AD) continues to be one of the most difficult and common neurodegenerative diseases, impacting millions of people globally.

16 Apr 2024

Study Reveals How Cells Recycle Proteins in Response to Nutrient Starvation

A new study details how nutrient-starved cells divert protein transport stations to cellular recycling centers to be broken down, highlighting a novel approach cells use to deal with stressful conditions.

15 Apr 2024

Rare YKT6 Gene Variants Linked to New Neurological Disorder

A recent collaborative study has discovered rare variants in the YKT6 gene as the cause of a new neurological disorder characterized by developmental delays along with severe progressive liver disease and a potential risk for liver cancer.

2 Apr 2024

New Study Sheds Light on Blood-Brain Barrier Dysfunction in Aging

The central nervous system requires a tightly controlled environment for the neurons in the brain to function properly and be able to process information. The blood-brain barrier, which is maintained by specific brain endothelial cells lining blood vessel inner walls, controls the exchange of chemicals between the neurological and circulatory systems.

25 Mar 2024

Research Reveals Unforeseen Functions for Autophagy Genes in Neuronal Health and Aging

Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, Sanford Burnham Prebys and Rutgers University have uncovered possible novel functions

5 Jan 2024

Researchers Identify Key Protein in Maintaining Two Organelles, Thereby Preventing Cellular Aging

Healthy organelles are essential to the operation of the cell, just as healthy organs are essential to human well-being.

2 Jan 2024

Cracking the Code of the Cytoplasm: How Cells Organize Protein Production

Back in 2018, the lab of Christine Mayr, MD, PhD, at Memorial Sloan Kettering Cancer Center (MSK) introduced the world to a key cellular component that had been hiding in plain sight.

22 Dec 2023

NEMO Protein Promotes Degradation of Harmful Alpha-Synuclein Aggregates in Parkinson's Disease

Researchers have identified a mechanism that promotes the breakdown of harmful protein deposits. If it malfunctions, it can lead to Parkinson’s disease.

21 Dec 2023

Deciphering the Structure and Function of PLD3 in Cellular Waste Disposal

If we don't take out the trash regularly, our homes become unpleasant and even a danger to our health.

21 Dec 2023

Study Elucidates How Mutant NPM1 Protein Drives Leukemia by Activating Autophagy System

In a recent study, scientists led by Professor Stefan Müller from Goethe University's Institute of Biochemistry II investigated a specific form of blood cancer known as acute myeloid leukemia, or AML.

5 Dec 2023

Unraveling Stem Cell Destiny in Intestinal Organoids

Stem cells possess the remarkable ability to differentiate and replace deceased or impaired cells within the body.

27 Nov 2023

Scientists Uncover New Insights into Cellular Recycling Process

Recycling is just as essential in cells as in our more familiar macroscopic world. Cells continuously generate waste products and accumulate damaged components while performing regular functions.

3 Nov 2023

Kanazawa University Research: Researchers Define a Protocol for Narrow Cantilever Fabrication and High-Resolution Imaging of Living Cells Using AFM

Researchers at Kanazawa University report in STAR Protocols procedural details and tips for nanoendoscopy-AFM, for capturing images of nanoscale structures inside living cells.

12 Sep 2023

Study Solves Mystery and Establish the Mechanism Underlying SLC29A3 Disorders

In humans, the SLC29A3 gene regulates the function of lysosomes to control waste recycling in cells such as macrophages (that engulf and destroy foreign bodies).

23 Aug 2023

Scaffolding Protein Helps in the Creation of Biomolecular Condensate

Biomolecular condensates are loosely organized assemblies that carry out a variety of vital tasks inside all live cells. However, the mechanism by which proteins and other biomolecules combine to create these assemblies within cells is not fully known.

16 Aug 2023

Extrusion-Mediated Self-Renewal: A New Way for Kidney Cells to Stay Healthy

University of Texas at Dallas scientists have discovered a previously unknown "housekeeping" process in kidney cells that ejects unwanted content, resulting in cells that rejuvenate themselves and remain functioning and healthy.

14 Jul 2023

Characterizing a Pivotal Time in Mammalian Embryonic Development

Many of life’s secrets are hidden in the initial stages of embryonic development. Unraveling these mysteries can aid in the understanding of early development and birth abnormalities, as well as the creation of innovative regenerative medicine treatments.

31 May 2023