Metabolic Disease News and Research

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New Mechanism Underpins Paternal Methylation Imprinting

Scientists at the Van Andel Institute and its partners have discovered a critical component of a system that annotates genetic information before it is transferred from fathers to their offspring.

7 Sep 2023

Single Injection of CRISPR Gene-Editing Treatment Safely Removes SIV From Non-Human Primates

A single injection of a novel CRISPR gene-editing treatment safely and efficiently removes SIV – a virus related to the AIDS-causing agent HIV – from the genomes of non-human primates, scientists at the Lewis Katz School of Medicine at Temple University now report.

17 Aug 2023

Novel Gene-Editing Strategy Harnesses Unusual Protective Ability to Eliminate HIV-1 Infection

Genetic alterations that give rise to a rare, fatal disorder known as MOGS-CDG paradoxically also protect cells against infection by viruses.

22 May 2023

Next-Generation Sequencing Provides New Insights into Mutations of Mitochondrial DNA

A high-throughput single-cell single-mitochondrial genome sequencing technology known as iMiGseq has provided new insights into mutations of mitochondrial DNA (mtDNA) and offers a platform for assessing mtDNA editing strategies and genetic diagnosis of embryos prior to their implantation.

17 Apr 2023

Novel inhibitor, hopeaphenol, blocks HIV expression

In the United States, around 1.2 million people are living with HIV as of 2022. Many of these people can now live productive, symptom-free lives thanks to antiretroviral therapies, but a solution that permanently removes HIV from an infected person’s body is still a long way off.

30 Mar 2023

Socioeconomic and genetic factors likely interact in an additive way to increase risk of metabolic diseases

New research led by investigators at Massachusetts General Hospital, a founding member of Mass General Brigham, indicates that socioeconomic and genetic factors likely interact in an additive way to affect people's risks of developing obesity and type 2 diabetes.

8 Mar 2023

BIDMC researchers develop a transformative approach to make more of beige adipose tissues

Once considered an inert tissue, fat – or adipose tissue – is now known to play an active role in the body's critical functions by secreting hormones that regulate hunger and body temperature.

18 Aug 2022

Research may lead to new therapies for metabolic disorders and other diseases

Researchers at UT Southwestern have uncovered a molecular path that allows cells to detect when their lipid supplies are running low, triggering a flurry of activity that avoids starvation.

23 May 2022

Scientists reveal the origins and provide a detailed ID card of pancreatic endocrine stem cells

The pancreas is a key metabolic regulator. When pancreatic beta cells cease producing enough insulin, blood sugar levels rise dangerously — a phenomenon known as hyperglycemia — thus triggering diabetes.

20 Apr 2022

Breakthrough discovery provides a desirable drug target to tackle metabolic diseases

In a breakthrough discovery, scientists from The University of Texas Health Science Center at San Antonio today reported that inhibiting a liver enzyme in obese mice decreased the rodents' appetite, increased energy expenditure in adipose (fat) tissues and resulted in weight loss.

6 Apr 2022

Researchers create an atlas of cell types present in the white adipose tissue of humans, mice

Once considered to be inert, white adipose tissue is now recognized to be dynamic and to play an interactive role in a wide array of biological and metabolic processes.

21 Mar 2022

US research reveals the role of Heparan Sulfate in obesity

AMSBIO reports how researchers at the Washington University School of Medicine (St. Louis, USA) have used their 10E4 Heparan Sulfate (HS) antibody in pioneering obesity research to quantify the role of HS in the process of intercellular mitochondria transfer to macrophages.

From AMS Biotechnology 1 Mar 2022

Metabolic Disease News and Research

New Mechanism Underpins Paternal Methylation Imprinting

Single Injection of CRISPR Gene-Editing Treatment Safely Removes SIV From Non-Human Primates

Novel Gene-Editing Strategy Harnesses Unusual Protective Ability to Eliminate HIV-1 Infection

Next-Generation Sequencing Provides New Insights into Mutations of Mitochondrial DNA

Novel inhibitor, hopeaphenol, blocks HIV expression

Socioeconomic and genetic factors likely interact in an additive way to increase risk of metabolic diseases

BIDMC researchers develop a transformative approach to make more of beige adipose tissues

Research may lead to new therapies for metabolic disorders and other diseases

Scientists reveal the origins and provide a detailed ID card of pancreatic endocrine stem cells

Breakthrough discovery provides a desirable drug target to tackle metabolic diseases

Researchers create an atlas of cell types present in the white adipose tissue of humans, mice

US research reveals the role of Heparan Sulfate in obesity

New gene critical for daily behavioral rhythms discovered

Study analyzes the health benefits of time-restricted eating

Metagenomic sequencing helps examine differences in the gut microbiome after injury

Study shows why obese mothers tend to have children susceptible to metabolic diseases

Novel compounds may lead to potential treatment for rare terminal childhood illness

Hormone that suppresses food intake could help tackle obesity

Obese, pregnant women can reduce infants' health risks through improved diet, physical activity

Environmental risk factors are important determinants of cardiovascular disease

The Last Piece of Our Genome: Sequencing the Y Chromosome

Understanding the Importance of Entrepreneurship in the Life Sciences Community

Supporting Informed Decisions on Malaria Biocontrol Interventions

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