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Scientists Unravel the Mystery of Parkinson's Disease With 3D Protein Structures

Scientists at St. Jude Children's Research Hospital revealed the complex structure of two Parkinson's disease-related proteins, both of which are implicated in late-onset cases.

26 Dec 2023

NEMO Protein Promotes Degradation of Harmful Alpha-Synuclein Aggregates in Parkinson's Disease

Researchers have identified a mechanism that promotes the breakdown of harmful protein deposits. If it malfunctions, it can lead to Parkinson’s disease.

21 Dec 2023

NTNU Develops Dual-Mechanism Antibiotic Strategy to Combat Antimicrobial Resistance

NTNU has developed a promising antibiotic candidate against MRSA. Behind the discovery lies a methodology that may be important in the fight against antimicrobial resistance.

18 Dec 2023

Innovative Machine Learning Tool Predicts Functional Consequences of Genetic Variants

In a recent research, scientists from the Icahn School of Medicine at Mount Sinai unveiled LoGoFunc, an innovative computational tool designed to forecast both pathogenic gain- and loss-of-function variants throughout the genome.

15 Dec 2023

Study Elucidates How Mutant NPM1 Protein Drives Leukemia by Activating Autophagy System

In a recent study, scientists led by Professor Stefan Müller from Goethe University's Institute of Biochemistry II investigated a specific form of blood cancer known as acute myeloid leukemia, or AML.

5 Dec 2023

New Irreversible Inhibitor Overcomes Drug Resistance in Cancer Cells

The concept of irreversible inhibitors binding permanently to a target protein has garnered growing interest for potential applications in drug development.

30 Nov 2023

New Model Reveals How Cells Maintain Epigenetic Memory During Cell Division

Every cell in the human body contains the same genetic instructions, encoded in its DNA. However, out of about 30,000 genes, each cell expresses only those genes that it needs to become a nerve cell, immune cell, or any of the other hundreds of cell types in the body.

17 Nov 2023

Rare Genetic Variant Found to Protect Against Alzheimer's Disease

Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the "Christchurch mutation" can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most common form of Alzheimer's disease.

14 Nov 2023

Epidemiology and Genetic Underpinnings of Clonal Hematopoiesis

A comprehensive new study from deCODE genetics, a subsidiary of Amgen, published today in Nature Genetics, provides insights into the epidemiology and somatic and germline genetics of clonal hematopoiesis.

7 Nov 2023

Plants Exploit Randomness to Avoid Mitochondrial Damage

Humans wouldn't last long without plant mitochondria and chloroplasts. These essential compartments of plant cells famously capture sunlight and power plant life – and so, ultimately, provide all the food we eat.

7 Nov 2023

Hidden Genetic Variations can be Detected Using New Nijmegen Method

Many hidden genetic variations can be detected with Chameleolyser, a new method developed in Nijmegen.

2 Nov 2023

Study Identifies Risk Genes and Regulatory Variants for Colorectal Cancer by Integrating Multi-Omics Data

This study was led by Prof. Xiao-Ping Miao' team from the School of Public Health, Wuhan University, in collaboration with Prof. Shaokai Zhang from the Henan Cancer Hospital.

2 Nov 2023

Genetics can Improve the Diagnostic Value of Cyanobacterial Biomarkers

Cyanobacteria are a key species in Earth's history, as they introduced atmospheric oxygen for the first time. The analysis of their evolution therefore provides important insights into the formation of modern aerobic ecosystems.

30 Oct 2023

Unraveling the Impact of Genetic Mutations on Future Generations

Regarding the structure of the human genome, it is only a matter of time until detrimental genes, which have the potential to jeopardize future generations, emerge within a population.

26 Oct 2023

Shark Survival Through the Ages: Unveiling Genetic Secrets

Sharks, having thrived for millions of years, exhibit a rare susceptibility to cancer while displaying heightened sensitivity to environmental shifts.

24 Oct 2023

Reassessment of the Role of Background Mutations in Genome Editing

More than a thousand years ago, tomatoes evolved through natural mutations. After human evolution, they cherry-picked tomatoes with preferred traits.

20 Oct 2023

Study Links Autism Gene to Broad Spectrum of Molecular and Cellular Defects

Researchers have used CRISPR gene editing, stem cells and human neurons to study the impact of a gene that is commonly mutated in autism.

6 Oct 2023

Research Offers a Promising Avenue for Improving T-Cell-Based Cancer Therapies

Using laboratory-grown cells from humans and genetically engineered mice, scientists at Johns Hopkins Medicine say they have evidence that modifying a specific protein in immune white blood cells known as CD8+ T cells can make the cells more robust, potentially opening the door for better use of people's own immune system T cells to fight cancer.

4 Oct 2023

Scientists Explain How Enhancer Reprogramming Promotes Tumor Cell Growth

Cancer cells can boost tumor development by hijacking enhancer DNA, which is typically utilized when tissues and organs form, according to researchers at the University of Toronto (U of T).

29 Sep 2023

Discovering the Key Molecule Involved in Bacterial Locomotion

A research team led by Professor Emeritus Michio Homma and Professor Seiji Kojima from the Graduate School of Science at Nagoya University, in partnership with Osaka University and Nagahama Institute of Bio-Science and Technology, has gained fresh insights into the mechanism of bacterial locomotion.

20 Sep 2023