Nucleotide News and Research

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Unveiling the Molecular Mechanisms of CRISPR-Cas10's Cellular Shutdown

CRISPR-Cas9 can elegantly and precisely cut away any desired region of DNA and has long been compared to a type of genetic scissors.

29 Oct 2024

Unlocking the Secrets of Life Through Synthetic Biology

It is one of the most fundamental questions in science: how can lifeless molecules come together to form a living cell? Bert Poolman, Professor of Biochemistry at the University of Groningen, has been working on this problem for over twenty years.

22 Oct 2024

Study Unlocks Mechanisms Behind Nucleosome Arrays Using Signal Theory and Machine Learning

Findings show that machine learning can accurately predict nucleosome positions, emphasizing the relationship between nucleosome architecture and gene activity.

17 Oct 2024

Comprehensive multi-omics approach reveals detailed insights into diabetes mechanisms

In a recent study published in Nature Communications, researchers utilized a comprehensive multi-omics approach, integrating genomic, proteomic, and metabolomic data from a diverse cohort, to uncover detailed molecular interactions and identify distinct diabetes subgroups.

20 Sep 2024

Modified Nucleotides Boost saRNA Vaccine Efficacy and Protection Against SARS-CoV-2

Modified nucleotides like m5C in saRNA enhance vaccine efficacy, stability, and reduce inflammation, offering a promising approach for SARS-CoV-2 protection.

18 Sep 2024

A Novel Method for Incorporating Non-Canonical Amino Acids into Proteins

Every basic biology lesson teaches that proteins are made up of combinations of 20 distinct amino acids, which are ordered in various patterns similar to words.

12 Sep 2024

CRISPR/Cas System Revolutionizes Tumor Variant and Biomarker Detection

The CRISPR-Cas system is transforming tumor biomarker detection, enabling ultra-sensitive diagnostics and improving accuracy in cancer detection and monitoring.

4 Sep 2024

Pan-Pathogen Deep Sequencing: A New Strategy in Combating Nosocomial Antimicrobial Resistant Bacterial Infections

Deep sequencing of bacterial cultures reveals insights into nosocomial infections and antimicrobial resistance, enhancing pathogen surveillance in hospitals.

30 Aug 2024

High-Speed Atomic Force Microscopy Reveals Cofilin Binding Patterns in Actin Filaments

Researchers at Kanazawa University report in eLife on deciphering the actin structure-dependent preferential cooperative binding of cofilin.

29 Aug 2024

The Influence of 'Silent' Mutations on Genetic Disorders

Genetic disorders -; like cystic fibrosis and Huntington's disease -; are considered incurable, with gene mutations occurring in essentially every cell of the body.

29 Aug 2024

Chloroplast Genome Research Enhances Identification and Breeding of Tea-Oil Camellia Species

A research team sequenced and analyzed the complete chloroplast genomes of C. oleifera and C. meiocarpa, uncovering significant differences that clarified their phylogenetic relationship.

20 Aug 2024

CRISPR-Cas: A Promising Tool For Combatting Antibiotic-Resistant Staphylococcus aureus

Using CRISPR-Cas systems in various studies to detect and treat Staphylococcus aureus.

12 Aug 2024

From CRISPR-Cas to Fanzor system: New frontiers in gene editing

The features of various CRISPR-Cas systems, including CRISPR-associated transposons (CASTs) and the eukaryotic equivalent of CRISPR-Cas systems, Fanzor systems.

9 Aug 2024

DNA Sequence Variants Drive Link Between Methylation and Gene Expression

The relationship between DNA methylation and gene expression is driven by sequence variants, according to a recent study conducted by researchers at deCODE Genetics, an Amgen subsidiary.

25 Jul 2024

Decoding Dengue: The Use of Less Efficient Codons for Viral Advantage

Mosquito-borne viral infections once confined to tropical regions are spreading. Dengue virus infects up to 400 million people worldwide each year according to World Health Organization estimates, and no available treatments exist for this disease.

24 Jul 2024

UNC Charlotte Study: SARS-CoV-2 Variants BA.2.86 and JN.1 Show Minimal Immune Evasion

New research from UNC Charlotte's Center for Computational Intelligence to Predict Health and Environmental Risks (CIPHER) has found that the two recent and prevalent strains of the virus that cause COVID-19, SARS-CoV-2 variants BA.2.86 and JN.1, are not significantly better than their predecessor Omicron at evading immune responses and causing infections despite having a high number of mutations compared to Omicron.

22 Jul 2024

Vps21 Pathway's Role in Morphological Transitions and Mating of Candida albicans

This study was led by Dr. Guanghua Huang (School of Life Sciences, Fudan University). The team discovered that the conserved Vps21 signaling pathway plays critical roles in the regulation of white-opaque switching and mating in Candida albicans, a major human fungal pathogen.

18 Jul 2024

Harnessing Enzymes for Making RNA Therapeutics

While the COVID-19 vaccines introduced many people to RNA-based medicines, RNA oligonucleotides have already been on the market for years to treat diseases like Duchenne Muscular Dystrophy and amyloidosis.

15 Jul 2024

New Insights into How Cells Fine-Tune Protein Assembly

Imagine the body as a bustling factory constantly assembling proteins, the building blocks that keep everything running smoothly.

26 Jun 2024

Scientists Identify Gene Region that Fuels Asthma Inflammation

Pollen and house dust mites are two common allergens that cause respiratory distress in asthma patients. But type-2 helper T (Th2) cells and group-2 innate lymphoid cells (ILC2s) release a class of proteins known as type-2 cytokines in response to a variety of asthma triggers. GATA-binding protein 3 (GATA3) is essential for the maturation of Th2 and ILC2.

25 Jun 2024