Oxidative Stress News and Research

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Oxidative Stress is a condition in which antioxidant levels are lower than normal. Antioxidant levels are usually measured in blood plasma.

Researchers Uncover Previously Unknown Inactive Form of p38a Protein

p38a protein, a key enzyme in the regulation of various cellular functions, plays a crucial role in some diseases, including cancer, chronic inflammation, and neurodegenerative conditions.

20 Dec 2023

Prion Protein Forms Dynamic Liquid Condensates to Regulate Copper Ions

In an innovative research article published in Science Advances, scientists from the Federal University of Rio de Janeiro (UFRJ) and the German Center for Neurodegenerative Diseases (DZNE-Berlin) illuminate the intricate interplay between the prion protein and copper ions in the physiopathology of live cells.

4 Dec 2023

Unveiling the Role of Heat Shock Proteins

A protective function against protein clumping is provided by a heat shock protein within cells.

27 Nov 2023

Unveiling Epidermal Hemoglobin: A Breakthrough in Skin Research

Scientists have, for the first time, demonstrated the presence of hemoglobin—a protein primarily known for its role in binding with oxygen within red blood cells—in the epidermis, the outermost tissue layer of human skin.

20 Nov 2023

Novel Bacterial Protein can Prolong Cell Longevity by Acting Directly on Mitochondria

Researchers at the University of São Paulo (USP) in Brazil, partnering with colleagues in Australia, have identified a novel bacterial protein that can keep human cells healthy even when the cells have a heavy bacterial burden.

10 Nov 2023

Gene Therapy Shows Promise for Muscular Dystrophy Patients

Researchers at Cincinnati Children’s Hospital reveal how damage to the cell’s energy factory causes muscle wasting. Closing a pore in the mitochondrial membrane in gene-edited mice prevents disease progression.

28 Aug 2023

Polyphenols in Muscadine Wine May Help Perk Up Sagging Skin

Could muscadine wine help perk up sagging skin? According to a new study, women who drank two glasses of dealcoholized muscadine wine daily showed significant improvements in the elasticity and water retention of their skin compared with those who consumed a placebo.

25 Jul 2023

Bioprocessing Breakthrough: Xheme Non-Toxic, Multifunctional Additive Eliminates Oxidative Stress

Oxidative stress, caused by an imbalance of free radicals and antioxidants, regularly reduces the yield of pharmaceuticals and therapeutics produced via bioprocessing by about 10-15%. Now, Xheme, Inc.'s Xheme Multifunctional Additive (XMA), a programmable non-toxic nanoporous microparticle, has demonstrated the ability to significantly reduce or eliminate the damage of oxidative stress in bioprocessing conditions.

25 Jul 2023

TTUHSC and TTU Researchers Uncover Promising Leads in the Fight Against Leishmaniasis

Leishmaniasis is a tropical disease caused by parasites known as Leishmania, which are transmitted to humans and animals through the bites of more than 90 species of sand flies.

23 Jun 2023

Exploring the Regulatory Mechanism and Physiological Significance of P62 Phosphorylation

Nuclear factor erythroid 2-related factor 2 (NRF2) is a master transcription factor with a role in maintaining oxidative stress response. It can be triggered by both redox-dependent and redox-independent pathways.

13 Jun 2023

Chemical in Widely Used Sweetener is "Genotoxic", Study Finds

A new study finds a chemical formed when we digest a widely used sweetener is "genotoxic," meaning it breaks up DNA.

1 Jun 2023

Identifying Drugs to Put the Brakes On Accelerated Aging From HIV Infection, Treatment

Antiretroviral cocktails can make human immunodeficiency virus, or HIV, undetectable and untransmittable, but both the virus and its treatment can also accelerate aging of bone and muscle.

24 May 2023

Researchers Develop a System to Deliver Antioxidants to the Mitochondria

A new drug delivery system delivers an antioxidant directly to mitochondria in the liver, mitigating the effects of oxidative stress.

11 May 2023

Inhibiting a Tiny RNA Could Help Improve Immune, Bone, and Muscle Health With Age

Inhibiting a tiny RNA whose levels significantly increase with age, along with problems like weaker bones and sagging muscles, may be a way to keep our bodies more youthful and healthy, scientists say.

3 May 2023

First Chronic Wound Murine Model to Profile the Effects of Cellular Senescence

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 8, entitled, "A chronic wound model to investigate skin cellular senescence."

2 May 2023

Previously Unknown Protein Reveals RNA Repair Mechanism in Humans

Ribonucleic acids (RNAs) are single-stranded molecules that are found in all living organisms’ cells. As “transcripts” of human genes, mRNAs, for instance, play a role in the translation of genetic information by bearing the instructions for the production of a protein in their own sequence.

26 Apr 2023

Revealing an Unanticipated Mechanism for Chaperone-Mediated Ribosome Repair

Researchers have discovered that if oxidative stress destroys protein factories known as ribosomes, repair crews may go in to assist in repairing the damage so that production may restart rapidly.

26 Apr 2023

Key Enzyme in Sugar Metabolism Plays Role in Protecting Cancer Cells

A key enzyme in sugar metabolism is inactivated particularly easily and efficiently by oxidative stress.

7 Apr 2023

Scientists shed new light on aging processes in the brain

Scientists from the Trinity Biomedical Sciences Institute (TBSI) have shed new light on aging processes in the brain.

9 Mar 2023

Adding antioxidants to cell cultures for efficient production of antibodies

Researchers at the Department of Chemical Engineering, Indian Institute of Technology, India, have investigated the effects of oxidative stress on the production of monoclonal antibodies (mAbs), and how antioxidants can alleviate this stress to improve their performance.

16 Feb 2023