Schizophrenia News and Research

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Schizophrenia is a chronic debilitating disorder which affects more than two million Americans, and millions more worldwide. While significant progress has been made in understanding the disease and developing treatments, there remains a significant unmet medical need. More than 50% of patients switch their medication in a given year due to either poor response or the experience of adverse events.

Schizophrenia-Linked Chromosome Deletion Affects Mitochondria

Investigators are learning more about how schizophrenia develops by investigating the most powerful known genetic risk factor.

22 Aug 2023

New Class of Brain Inhibitory Neurons May Contribute to Autism and Schizophrenia

A University of California, Irvine-led team of researchers working at the Center for Neural Circuit Mapping find links between brain disorders and dysfunction of newly identified inhibitory brain cell types.

26 Jul 2023

Cryo-EM Reveals Structure of GABA Transporter

Using Cryo-EM, a powerful microscopy technique, researchers at IISc and collaborators have decoded the molecular architecture of a transporter protein controlling the movement of a key neurotransmitter.

7 Jul 2023

Deep Learning Model Accurately Predicts RNA-Targeting CRISPR Activity

According to new research published in Nature Biotechnology, artificial intelligence can predict on- and off-target behavior of CRISPR tools that target RNA rather than DNA.

5 Jul 2023

Neurotransmitter Receptor Patterns Define Key Organizational Principles in the Brain

Receptor patterns define key organizational principles in the brain, scientists have discovered.

20 Jun 2023

Scientists Discover the Mechanisms of Synaptic Pruning in Brain Development

Researchers at Kyushu University have uncovered the mechanisms of a fundamental yet critically under-looked phase in brain development: synaptic pruning.

8 Jun 2023

CSHL Scientists Flip the Script on Autism Genetics

Cold Spring Harbor Laboratory researchers have flipped the script on autism spectrum disorder (ASD) genetics.

23 May 2023

STING-seq Discovers Causal Variants and Genetic Mechanisms for Blood Cell Traits

A major challenge in human genetics is understanding which parts of the genome drive specific traits or contribute to disease risk. This challenge is even greater for genetic variants found in the 98% of the genome that does not encode proteins.

5 May 2023

Markers Indicating Early Signs of Schizophrenia Identified

For the first time, a global study group headed by investigators at Virginia Commonwealth University has found markers that might point out early if a person is susceptible to schizophrenia in the early stage itself.

28 Apr 2023

Understanding the Origins of Human Disease Using the Power of Evolutionary Genomics

Hundreds of scientific studies have been conducted over the years to find the genes underlying common human traits, from eye color to intelligence and physical and mental illnesses.

28 Apr 2023

Research Shows How Mammalian Genomes Have Developed Over the Course of Evolution

Why is it that certain mammals have an exceptional sense of smell, some hibernate, and yet others, including humans, are predisposed to disease?

28 Apr 2023

Key Mediator of Anhedonia-Like Behavior Identified

Researchers uncovered a stress-regulated gene that is important in the relationship between chronic stress and typical depressed behavior in mice.

10 Apr 2023

Study investigates schizophrenia risk across African ancestry

Researchers have identified two previously unknown genes linked to schizophrenia and newly implicated a third gene as carrying risk for both schizophrenia and autism. Led by the Icahn School of Medicine at Mount Sinai, the multi-center study further demonstrated that the schizophrenia risk conferred by these rare damaging variants is conserved across ethnicities. The study may also point to new therapeutics.

14 Mar 2023

Novel model tracks hippocampal synaptic plasticity to reveal molecular mechanisms

The accumulation of amyloid beta proteins, which encourage synaptic malfunction, causes cognitive decline in Alzheimer’s disease (AD), according to scientific evidence.

10 Mar 2023

Lieber Institute awarded $1 million grant to foster racial diversity across neuroscience

The Lieber Institute for Brain Development has received a $1 million, two-year grant from the Chan Zuckerberg Initiative to support the work of the African Ancestry Neuroscience Research Initiative (AANRI) to promote racial equity throughout the field of neuroscience.

28 Feb 2023

Accelerating the structure-guided discovery of chemogenetic tools

In order to more fully understand how diseases arise in the brain, scientists must unravel the intricate way neurons relay messages (either chemical or electrical) along a complex web of nerve cells. One way is by using a tool called DREADDs, which stands for Designer Receptors Activated by Designer Drugs.

21 Feb 2023

Research reveals gene expression changes in two brain regions of individuals with cocaine use disorder

Individuals with cocaine use disorder exhibit gene expression changes in two brain regions: the nucleus accumbens, a region associated with reward, and the caudate nucleus, a region mediating habit formation, according to research conducted at the Icahn School of Medicine at Mount Sinai and published February 10 in Science Advances.

13 Feb 2023

Genetic variants that increase the risk of ADHD identified

Why are some people diagnosed with ADHD while others are not? And when is the seed of ADHD sown, in life or the womb?

10 Feb 2023

U.S. people show interest in using genetic technologies to improve offspring education

An article published today in the journal Science indicates that a substantial proportion of Americans are willing to use an essentially unregulated reproductive genetic technology to increase the chances of having a baby who is someday admitted to a top-100 ranked college.

10 Feb 2023

The 12-hour cyclic gene activity abnormalities in schizophrenic brains

The first proof of 12-hour cycles of gene activity in the human brain is presented by researchers at the University of Pittsburgh School of Medicine in the United States.

From University of Pittsburgh 26 Jan 2023

Schizophrenia News and Research

Schizophrenia-Linked Chromosome Deletion Affects Mitochondria

New Class of Brain Inhibitory Neurons May Contribute to Autism and Schizophrenia

Cryo-EM Reveals Structure of GABA Transporter

Deep Learning Model Accurately Predicts RNA-Targeting CRISPR Activity

Neurotransmitter Receptor Patterns Define Key Organizational Principles in the Brain

Scientists Discover the Mechanisms of Synaptic Pruning in Brain Development

CSHL Scientists Flip the Script on Autism Genetics

STING-seq Discovers Causal Variants and Genetic Mechanisms for Blood Cell Traits

Markers Indicating Early Signs of Schizophrenia Identified

Understanding the Origins of Human Disease Using the Power of Evolutionary Genomics

Research Shows How Mammalian Genomes Have Developed Over the Course of Evolution

Key Mediator of Anhedonia-Like Behavior Identified

Study investigates schizophrenia risk across African ancestry

Novel model tracks hippocampal synaptic plasticity to reveal molecular mechanisms

Lieber Institute awarded $1 million grant to foster racial diversity across neuroscience

Accelerating the structure-guided discovery of chemogenetic tools

Research reveals gene expression changes in two brain regions of individuals with cocaine use disorder

Genetic variants that increase the risk of ADHD identified

U.S. people show interest in using genetic technologies to improve offspring education

The 12-hour cyclic gene activity abnormalities in schizophrenic brains

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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