Splicing News and Research

RSS

De Novo Mutations may Play a Role in Male Infertility

In this interview, we speak to Dr. Miguel J. Xavier about his latest research into male infertility and how de novo mutations may play a part.

19 Nov 2021

Study reveals mechanisms promoting overall glioma tumor growth

Researchers from Northwestern Medicine unearthed the epigenetic processes involved in the regulation of multiple oncogenes in glioma cells.

31 Aug 2021

Study finds the link between circular RNA and alternative splicing in gastric cancer

At the Chinese Academy of Sciences, scientists have now come up with a mechanism used by circular RNA to inhibit the metastasis of gastric cancer cells.

23 Aug 2021

Researchers identify a novel pathomechanism leading to Usher syndrome

Human Usher syndrome (USH) is the most common form of hereditary deaf-blindness. Sufferers can be deaf from birth, suffer from balance disorders, and eventually lose their eyesight as the disease progresses.

12 Jul 2021

'Enabler cells' in tumors could promote cancer metastasis

Just a small number of cells found in tumors can enable and recruit other types of cells nearby, allowing the cancer to spread to other parts of the body, report Georgetown Lombardi Comprehensive Cancer Center scientists.

17 Jun 2021

Researchers systematically analyze alternative splicing in the family of glutamate receptors

Alternative splicing can lead to the formation of numerous protein variants. For the first time, alternative splicing has now been systematically analysed for the family of glutamate receptors.

17 Jun 2021

“Topologically tunable” DNA-based material has potential applications in drug delivery, tissue regeneration

DNA is usually idealized as the “molecule of life,” but it is also a highly advanced polymer that can be used for cutting-edge materials. Apart from storing information, other interesting aspects of DNA are its topological and geometrical properties, like super-coiling and knotting.

31 May 2021

Study: Interaction between distant parts of RNA can regulate gene expression

Russian researchers have now investigated the role of double-stranded fragments of the maturing RNA and demonstrated that the interaction between faraway parts of the RNA can control gene expression.

20 Apr 2021

Study shows how tau aggregates promote Alzheimer’s disease

If looked deep into the brain of a patient with Alzheimer’s disease or those suffering from the most types of dementia or the concussion-associated syndrome, called chronic traumatic encephalopathy (CTE), there would be hairball-like tangles of a protein known as tau—a common suspected culprit.

20 Apr 2021

New CRISPR technology allows scientists to switch off any gene in human cells

Scientists have figured out how to modify CRISPR's basic architecture to extend its reach beyond the genome and into what's known as the epigenome -- proteins and small molecules that latch onto DNA and control when and where genes are switched on or off.

19 Apr 2021

Study sheds new light on age-related neurodegenerative disorders

Neurons cannot simulate their DNA and hence they work continuously to repair any damage caused to their genome.

2 Apr 2021

Study reveals mechanism by which ibuprofen prevents RAC1B alternative splicing in colorectal cells

Oncotarget published "Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells" which reported that although the molecular mechanism behind the antitumor properties of NSAIDs has been largely attributed to inhibition of cyclooxygenases , several studies have shown that the chemopreventive properties of ibuprofen also involve multiple COX-independent effects.

23 Mar 2021

New gene-drive technologies can help control crop pests

Robust new genetic engineering techniques have given researchers the ability to transform many sectors of global urgency.

8 Mar 2021

Study reveals process behind key cellular change in amyotrophic lateral sclerosis

A research team has discovered the trigger of a crucial cellular change in amyotrophic lateral sclerosis (ALS)—a form of motor neuron disease.

5 Mar 2021

Researchers identify gene variant associated with childhood asthma

Researchers at Henry Ford Health System, as part of a national asthma collaborative, have identified a gene variant associated with childhood asthma that underscores the importance of including diverse patient populations in research studies.

1 Mar 2021

Targeting RNA splicing can trigger antiviral immune pathways in triple-negative breast cancers

Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body's immune response.

15 Jan 2021

High-speed atomic force microscopy sheds light on structure, dynamics of intrinsically disordered proteins

Kanazawa University’s pioneering high-speed atomic force microscope technology has now shed light on the structure and dynamics of some of life’s most ubiquitous and inscrutable molecules – intrinsically disordered proteins.

29 Dec 2020

First functional analysis of cytokine IL-15L using rainbow trout

The cytokine family including interleukin-2 and -15 (IL-2 and IL-15) started out in a primitive vertebrate species with three related cytokines IL-2, IL-15, and IL-15-like (IL-15L), all sharing binding capacity for receptor chain IL-15Rα. IL-15L was conserved in fishes, reptiles, and some mammals but lost in humans and mice.

23 Nov 2020

Study shows CRISPR/Cas9 system can effectively treat metastatic cancers

Researchers have shown that the advanced CRISPR/Cas9 system is extremely effective in curing metastatic cancers.

19 Nov 2020

Light-activated liposomes could help deliver CRISPR gene therapy

Light-activated liposomes could help to deliver CRISPR gene therapy - and the method could prove safer and more direct than current methods.

16 Nov 2020