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Researchers map genetic networks controlling human regulatory T cell identity

Unlike most T cells, which launch immune responses against foreign molecules, regulatory T cells are the peacekeepers of the human immune system, damping down inflammatory reactions when they're not needed.

5 Oct 2020

Epigenetic alterations drive late-onset Alzheimer's disease

New findings suggest that late-onset Alzheimer's Disease is driven by epigenetic changes -- how and when certain genes are turned on and off -- in the brain. Results were published today in Nature Genetics.

29 Sep 2020

Study sheds light on how membrane proteins could be influenced by lipids

The cell membrane, the wall-like boundary between the cell interior and its outside environment, is primarily made up of two kinds of biomolecules: lipids and proteins.

25 Sep 2020

New data shows immunotherapy is beneficial for patients with gastric, esophageal cancers

New data presented at ESMO 2020 have shown that immunotherapy is beneficial for patients with gastric and esophageal cancers who currently have poor survival. (1-3)

24 Sep 2020

Combination treatment improves outcomes in advanced kidney cancer patients

An immunotherapy agent combined with a tyrosine kinase inhibitor drug significantly improved progression-free survival and reduced the risk of death compared to a single agent treatment in advanced kidney cancer patients, according to first results of a phase 3 clinical trial. The pivotal study could lead to a new treatment option for patients with metastatic kidney cancer.

24 Sep 2020

Study identifies genetic factors linked to higher risk of capecitabine-induced hand-foot syndrome

Capecitabine is a chemotherapy drug used for breast and colorectal Cancer cancer. It can extend survival rate by nearly 10%.

22 Sep 2020

How do hallucinogenic drugs exert their actions on the brain?

Not much is known about the fundamental mechanisms in the brain of hallucinogenic drugs and the way they induce their hallucinogenic effects.

21 Sep 2020

T cells play a vital role in controlling SARS-CoV-2 during acute phase of infection

Ever since SARS-CoV-2 first appeared, researchers have been trying to understand whether sometimes the immune system does more harm than good during the acute phase of COVID-19. The latest study by researchers at La Jolla Institute for Immunology clearly argues in favor of the immune system.

17 Sep 2020

Bioengineers detect the presence of maxRNA on the surface of human cells

Bioengineers have demonstrated that RNA produced by the human genome is found on the surface of human cells.

11 Sep 2020

Protein inhibitors neutralize SARS-CoV-2 infection in cell culture

Using innovative computer-based approaches, researchers have developed protein inhibitors that block the interaction between the SARS-CoV-2 virus and human cell receptor ACE2.

10 Sep 2020

Computer-designed proteins protect lab-grown human cells from SARS-CoV-2

Computer-designed small proteins have now been shown to protect lab-grown human cells from SARS-CoV-2, the coronavirus that causes COVID-19.

10 Sep 2020

Researchers explore link between uncontrolled inflammation and brain's immune cells

Inspired by the need for new and better therapies for neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, Rutgers University researchers are exploring the link between uncontrolled inflammation within the brain and the brain's immune cells, known as microglia.

9 Sep 2020

Researchers create an algorithm that predicts allosteric sites in proteins

A new technology that uses a protein's structure to predict the inner wiring that controls the protein's function and dynamics is now available for scientists to utilize.

4 Sep 2020

Study shows how tumor cells gain enhanced ability to deal with crowded tumor environment

Majority of animal cells must become spherical to undergo cell division. These cells achieve this shape by rounding up and deforming their neighboring cells.

3 Sep 2020

Non-coding RNA molecule helps lung cancer cells evade immune cells

Researchers in Spain have identified a non-coding RNA molecule that helps lung cancer cells proliferate and avoid being killed by the body's immune cells.

28 Aug 2020

Novel computational approach helps find genetic causes of severe childhood brain disorders

A team of researchers at Children's Hospital of Philadelphia affiliated with the CHOP Epilepsy Neurogenetics Initiative (ENGIN) have combined clinical information with large-scale genomic data to successfully link characteristic presentations of childhood epilepsies with specific genetic variants.

27 Aug 2020

Protein structural study may lead to more improved research on disease development

Researchers had identified an actin cytoskeketal nucleator, called Arp2/3 complex, more than 20 years ago.

26 Aug 2020

Study uncovers how the immune system generates effective antibodies

An in-depth Garvan study of how the immune system generates effective antibodies provides new insights for vaccine design.

25 Aug 2020

Each person's gut has a unique viral 'fingerprint'

Each person's gut virus composition is as unique as a fingerprint, according to the first study to assemble a comprehensive database of viral populations in the human digestive system.

25 Aug 2020

Researchers discover antibodies that may provide effective immunity against SARS-CoV-2

A new study by researchers at MassBiologics of UMass Medical School published in Nature Communications suggests that COVID specific IgA monoclonal antibodies may provide effective immunity in the respiratory system against the novel coronavirus - a potentially critical feature of an effective vaccine.

25 Aug 2020

therapeutics News and Research

Researchers map genetic networks controlling human regulatory T cell identity

Epigenetic alterations drive late-onset Alzheimer's disease

Study sheds light on how membrane proteins could be influenced by lipids

New data shows immunotherapy is beneficial for patients with gastric, esophageal cancers

Combination treatment improves outcomes in advanced kidney cancer patients

Study identifies genetic factors linked to higher risk of capecitabine-induced hand-foot syndrome

How do hallucinogenic drugs exert their actions on the brain?

T cells play a vital role in controlling SARS-CoV-2 during acute phase of infection

Bioengineers detect the presence of maxRNA on the surface of human cells

Protein inhibitors neutralize SARS-CoV-2 infection in cell culture

Computer-designed proteins protect lab-grown human cells from SARS-CoV-2

Researchers explore link between uncontrolled inflammation and brain's immune cells

Researchers create an algorithm that predicts allosteric sites in proteins

Study shows how tumor cells gain enhanced ability to deal with crowded tumor environment

Non-coding RNA molecule helps lung cancer cells evade immune cells

Novel computational approach helps find genetic causes of severe childhood brain disorders

Protein structural study may lead to more improved research on disease development

Study uncovers how the immune system generates effective antibodies

Each person's gut has a unique viral 'fingerprint'

Researchers discover antibodies that may provide effective immunity against SARS-CoV-2

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