The Xevo MRT Mass Spectrometer helps users achieve exceptional scientific results every time, whether they work in academia or industry. This cutting-edge QTof delivers a resolution of 100,000 FWHM at 100 Hz with sub-ppm mass accuracy, ensuring confident identification and boosting productivity in the laboratory.
Utilizing multi-reflecting time-of-flight (MRT) technology, this system provides consistent mass resolution across a wide m/z range, regardless of scan speed, even at the highest acquisition rates. This ensures exceptional data quality for scientific interpretation, making it ideally suited for large-scale studies in biomedical research.
The Xevo MRT Mass Spectrometer unlocks a new level of confidence, bringing a powerful analytical tool to every lab.
Overview
- Obtain maximum resolution and sensitivity, regardless of the acquisition speed, ensuring the user can distinguish analytes within complex matrices for thorough scientific interpretation.
- Investigate samples at biologically relevant concentrations with high mass accuracy for deeper insights.
- Accelerate the time to results by leveraging market-leading chemistry, separations, and advanced, pertinent informatics, all integrated with high-end technology in a versatile benchtop system.
- Achieve reliable, high-quality experimental outcomes and tackle the most challenging problems with exceptional system reproducibility and robustness.
- Attain both high resolution and speed without sacrificing analytical performance.

Unlocking a new level of confidence by bringing an analytical powerhouse to every lab. Image Credit: Waters Corporation

Flexible system layout to fit your lab. Image Credit: Waters Corporation

High-end technology to meet your most challenging analytical problems. Image Credit: Waters Corporation

Exceptional science for every lab, scientist, problem, question, and sample… solved. Image Credit: Waters Corporation
High Resolution and Speed Without Compromise
The Xevo MRT Mass Spectrometer's exceptional combination of high mass resolving power (100,000 FWHM) and mass accuracy (<500 parts per billion) is achieved consistently across all acquisition rates, up to 100 Hz. This peak performance, aligned with throughput levels crucial for complex and challenging analyses, enhances statistical power and confidence in results.
Unlike other high-resolution MS systems, its multi-reflecting time-of-flight technology provides consistent mass resolution across a wide mass range, regardless of scan speed. This holds true even at the fastest acquisition rates for both MS and MS/MS data, ensuring reliable identification of analytes in diverse samples and matrices – making it an ideal solution for metabolite profiling and discovery.

A representative triglyceride lipid at m/z 874 is provided at scan rates of 1, 5, 10, and 20 Hz, for which we can see that the mass resolution is maintained across all scan rates in the region of 80,000. Image Credit: Waters Corporation
Driving Efficiency Through Workflows
Unlock more efficient and impactful scientific discoveries with specialized workflows integrating column chemistries, separations, and informatics with the exceptional data quality delivered by the Xevo MRT Mass Spectrometer. The waters_connect platform empowers users to process and report the data according to their specific needs. Whether users utilize Waters-supported solutions or export data via mzML to custom-designed workflows, the company provides comprehensive support.
Waters has partnered with Mass Analytica™ and their leading metabolomic, lipidomic, and metabolite identification software packages: MARS, Lipostar2, and MassMetaSite. Through either the waters_connect Application Programming Interface (API) or the mzML file format, users can seamlessly transfer the data into the relevant software for statistical interpretation and analyte identification.
The DATA Convert application, integrated within the waters_connect platform, allows users to convert and export mzML file formats, ensuring a smooth integration of technology and informatics for every laboratory.

The waters_connect platform provides flexible data processing options, either using third-party applications via the waters_connect API or conversion of data sets to mzML file format. #https://mzio.io/#mzmine; §http://prime.psc.riken.jp/compms/msdial/main.html; and XCMS(TM) is a trademark of The Scripps Research Institute. Image Credit: Waters Corporation
Unlocking a New Level of Confidence
To directly address the challenges, Waters has adapted the pioneering cutting-edge technology of the SELECT SERIES MRT, bringing its raw power and resolution at high speed into a space-saving, adaptable benchtop system.
The Xevo MRT Mass Spectrometer is specifically engineered to integrate high-end technology into a benchtop platform, enabling users to tackle the most complex analytical problems. Its innovative acquisition system, featuring a dual gain analog-to-digital converter, provides long-term system stability across a wide dynamic range, ensuring exceptional data quality with consistent robustness and reproducibility.
The 4 m flight path, achieved through 8 reflections within the MRT mass analyzer, delivers resolution up to 100,000 FWHM at scan rates up to 100 Hz, providing ultimate MS/MS performance.
Now is the time to consistently achieve exceptional science.

The Xevo MRT Mass Spectrometer schematic. Image Credit: Waters Corporation