The core focus is seeking answers to the most complex scientific challenges, and the scientific tools utilized and the insights they generate can make all the difference. Featuring industry-leading separation capabilities, the ACQUITY UPLC I-Class PLUS System opens up new avenues for maximizing the resolution and sensitivity of the analytical methods. This enhancement leads to improved sample characterization and increased productivity, ultimately advancing the laboratory's scientific output.
The ACQUITY UPLC I-Class PLUS System empowers the lab to achieve highly efficient and rapid separations, thanks to its industry-leading ultra-low dispersion and delay volume. By generating narrow, ultra-efficient peaks, this system enhances the sensitivity of any connected mass spectrometer and simplifies the characterization of even the most complex samples.
ACQUITY UPLC I-Class PLUS System FTN-H PDA angled. Image Credit: Waters Corporation
Specifications
Source: Waters Corporation
| . |
. |
| Maximum operating pressure |
18,000 psi |
| pH Range* |
1–12.5 |
| Operating flow rate range |
Up to 2.0 mL/min |
| Sample flow path |
Stainless-steel |
| Sample carryover |
<0.001% (Caffeine) under UV conditions |
| Sample compartment |
4–40 °C |
| Pump options |
Binary |
| Solvent conditioning |
Active Pre-heating |
| Column tracking |
eCord Technology tracks column information and archives column usage |
| Column capacity |
Up to 2 columns of 150 mm length and up to 4.6 mm I.D. |
| Maximum sample capacity |
Up to 20 plates (with Sample Organizer) |
| Detector options |
PDA Detector
TUV Detector
FLR Detector
RI Detector
ELS Detector
Mass Spectrometers |
| External control |
Empower Software
MassLynx Software
waters_connect
UNIFI Scientific Information System |
Physical specifications
QSM or BSM, SM-FTN, CHA |
Width: 34.3 cm (13.5 in.)
Height: 71.1 cm (28.0 in.)
Depth: 71.2 cm (28.0 in.) |
* For specific test conditions, contact Waters sales representative
Overview
- Achieve precise and accurate binary solvent mixing with the Binary Solvent Manager, capable of handling up to four solvents and featuring an integrated solvent-select valve.
- Gain versatile sample injection options with both flow-through needle and fixed loop injector configurations to suit specific applications.
- Effectively manage ultra-low sample carryover through programmable method settings, ensuring compatibility even with the most sensitive mass spectrometers.
- Benefit from accurate temperature control across the entire column, with configurations available for one or two columns and active preheating.
- Enhance the performance of any mass spectrometer by achieving the highest chromatographic resolution, which minimizes interference from co-eluting compounds.
- Reduce the time and expense associated with annual qualification using the Waters Empower-based automated system qualification tool (SQT).
- This system is compatible with Empower, Masslynx, UNIFI, and various third-party software packages.
Recommended Use: Elevate the sample characterization capabilities and simultaneously boost productivity, driving scientific advancement in the lab.
Get a Clearer Picture of the Sample
The ACQUITY UPLC I-Class PLUS System enhances resolution by minimizing system dispersion, delivering separations that significantly amplify research insights.
This system helps to shorten analysis times, reduce solvent consumption, and accelerate access to the crucial data needed for timely decisions. Designed for seamless integration into the current LC workflow, the ACQUITY UPLC I-Class PLUS System provides a clear and detailed view of the sample's composition.
In this example, the impurity analysis of tetracaine was run under the same conditions on the ACQUITY UPLC I-Class PLUS System (system band spread of 4 µL) and a UHPLC system (system band spread of 20 µL). Significantly better resolution was achieved on the ACQUITY UPLC I-Class PLUS System. Image Credit: Waters Corporation
An Inlet That Improves the Performance of Any MS
The ACQUITY UPLC I-Class PLUS System is specifically engineered for the fast-paced environment of leading-edge research laboratories where LC-MS is a vital technique.
With the ACQUITY UPLC I-Class PLUS System, the lab will:
- Achieve enhanced resolution and ionization efficiency through narrow peak widths, improving mass spectrometry sensitivity.
- Benefit from industry-leading carryover performance, resulting in increased sensitivity.
- Improve sample characterization through selective isolation using multidimensional UPLC configurations.
- Attain exceptionally rapid analysis times due to its ultra-low delay volume.
A high sensitivity UPLC-MS/MS bioanalytical methodology for the quantification of midazolam and imipramine in rat plasma using the Xevo TQ Absolute Tandem Quadrupole Mass Spectrometer in combination with an ACQUITY UPLC I-Class PLUS System. Image Credit: Waters Corporation
Achieve Ultimate Peak Capacity with CORTECS Columns
When the ACQUITY UPLC I-Class PLUS System is combined with CORTECS 1.6 µm solid-core columns, scientists can achieve unprecedented levels of resolution, sensitivity, and overall chromatographic performance. This pairing of CORTECS Columns and the ACQUITY UPLC I-Class PLUS System allows for enhanced resolution for even the most challenging samples, providing the flexibility and power needed to rapidly separate a diverse range of compounds.
By pairing the ultra-low dispersion ACQUITY UPLC I-Class PLUS System with high-efficiency CORTECS Columns, you’ll achieve new levels of UPLC performance. These 1.6 µm columns deliver exceptional levels of efficiency, performance, and throughput, resulting in narrower peaks and higher peak capacity. Image Credit: Waters Corporation