The Robust Xevo TQ Absolute Mass Spectrometer

Achieve complete confidence in reaching lower limits of quantitation, even for challenging negative ionizing compounds, with the Xevo TQ Absolute—an instrument designed to deliver unmatched performance.

The Waters Xevo TQ Absolute is an exceptionally compact and sustainable tandem quadrupole mass spectrometer, designed to help the lab achieve and sustain high performance and productivity. Building on Xevo's renowned robustness, the Xevo TQ Absolute allows for precise quantification of challenging small-mass, negative-ionizing compounds with unparalleled sensitivity and confidence. All of this is achieved while ensuring that the ESG commitments are fully supported.

Specifications

System Hardware Specifications

Source: Waters Corporation

. .
API sources and ionization modes High-performance ZSpray dual-orthogonal API sources:
1) Multi-mode source – tool-free ESI/APCI/ESCi* (standard) NB – Dedicated APCI requires an additional probe (optional)
2) UniSpray ion source (optional)
3) Tool-free APCI probe (optional)
4) nanoFlow™ ESI source* (optional)
5) ASAP* (optional)
6) APGC ion source* (optional)
Optimized gas flow dynamics for efficient ESI desolvation
Tool-free source exchange
Vacuum isolation valve
Tool-free access to user serviceable elements
Plug-and-play probes
De-clustering cone gas
Software control of gas flows and heating elements
UniSpray ion source option UniSpray is an ionization technique designed to broaden the scope of compounds that can be analyzed in a single run, including those that typically optimize in ESI, APCI, or APPI. Enhanced ionization efficiency and desolvation allow the potential to combine several methodologies into one, or simply enable the operator to keep the same source for multiple methods, requiring less time performing set-up and routine maintenance, and more time delivering results.
Ion source transfer optics StepWave XS ion transfer optics delivering class-leading UPLC™-MS/MS sensitivity.
The unique off-axis design and segmented quadrupole second stage dramatically increases the efficiency of ion transfer from the ion source to the quadrupole MS analyzer at the same time as actively eliminating undesirable neutral contaminants
Mass analyzer Two high-resolution, high-stability quadrupole analyzers (MS1/MS2), plus pre-filters to maximize resolution and transmission while preventing contamination of the main analyzers
Collision cell T-Wave enabled for optimal MS/MS performance at high data acquisition rates;
Software programmable gas control
Detector Low-noise, off-axis, long-life photomultiplier XDR Detector
Vacuum system One splitflow turbomolecular pump
One vacuum backing pump
Dimensions Width: 43.0 cm (16.9 in.)
Height: 79.0 (31.1 in)
Depth: 96.0 (37.8 in)
Regulatory approvals/marks CE, CB, NRTL (CAN/US), RCM

* Not available with waters_connect.

System Software Specifications

Source: Waters Corporation

. .
Software Systems supported on waters_connect and MassLynx version 4.2 or later
System setup and method development System parameter checks and alerts
Integrated sample/calibrant delivery system + programmable divert valve Automated mass calibration
Automated sample tuning
Automated MRM method development
UPLC-MS/MS System Check – on-column performance test
Automated MRM scheduling (acquisition rate assignment) Dwell time, inter-channel delay time and inter-scan delay time for individual channels in a Multiple MRM experiment can be automatically assigned (using the Auto-Dwell feature) to ensure that the optimal number of MRM data points per chromatographic peak are acquired. The Auto-Dwell feature optimizes MRM cycle times to accommodate overlapping retention time windows. This greatly simplifies MRM method creation, irrespective of the number of compounds in a single assay, while at the same time ensuring the very best quantitative performance for every experiment
waters_connect Software The waters_connect Software provides a modern user experience with a HUB design and apps that provide a consistent connected user experience across all applications. It is built for applications with convenient access to scientific apps, allowing accelerated time-to-results and result quality. There are common utilities that complete the end-to-end workflow and help increase productivity and efficiency. Confidently report results with accurate, reliable, regulation-standard data from application-focused quantitative workflows with built-in traceability for utmost integrity.

 

Performance Capabilities

Source: Waters Corporation

. .
Acquisition modes Full scan MS
Product ion scan
Precursor ion scan
Constant neutral loss scan
Multiple reaction monitoring (MRM), Simultaneous Full scan, and MRM (RADAR)
RADAR An information-rich acquisition approach that allows you to collect highly specific quantitative data for target compounds while providing the ability to visualize all other components
Mass range 2 to 2048 m/z

 

Compare Xevo TQ Systems

Source: Waters Corporation

  Xevo TQ-S cronos Xevo TQ-S micro Xevo TQ-XS Xevo TQ Absolute
Dimensions (w x h x d) 35.6 x 60 x 93 cm 35.6 x 60 x 93 cm 61 x 70.7 x 99.5 cm 43 x 79 x 96 cm
Sensitivity key ★★ ★★★ ★★★★ ★★★★★
Mass range 2 to 2048 m/z 2 to 2048 m/z 2 to 2048 m/z 2 to 2048 m/z
Chromatographic configuration compatibility ACQUITY Arc*
ACQUITY Premier
ACQUITY UPC2*
ACQUITY UPLC
ACQUITY UPLC M-Class*
ACQUITY Premier
ACQUITY UPC2*
ACQUITY UPLC
ACQUITY UPLC M-Class*
APGC*
ACQUITY Premier
ACQUITY UPC2*
ACQUITY UPLC
ACQUITY UPLC M-Class*
APGC*
ACQUITY Premier
ACQUITY UPLC
ACQUITY UPLC M-Class*
APGC*
Ion sources compatibility APCI
ASAP*
ESCi*
ESI
UniSpray
APCI
APGC*
ASAP*
ESCi*
ESI
ionKey*
Nanoflow*
UniSpray
APCI
APGC*
ASAP*
ESCi*
ESI
ionKey*
Nanoflow*
UniSpray
APCI
APGC*
ASAP*
DESI XS*
ESCi*
ESI
Nanoflow*
UniSpray
Acquisition modes Full scan
Product scan
Precursor ion scan
Constant neutral loss scan
Multiple reaction monitoring (MRM)
Simultaneous Full Scan and MRM (RADAR) 
Full scan
Product scan
Precursor ion scan
Constant neutral loss scan
Multiple reaction monitoring (MRM)
Simultaneous Full Scan and MRM (RADAR)
Full scan
Product scan
Precursor ion scan
Constant neutral loss scan
Multiple reaction monitoring (MRM)
Simultaneous Full Scan and MRM (RADAR)
Full scan
Product scan
Precursor ion scan
Constant neutral loss scan
Multiple reaction monitoring (MRM)
Simultaneous Full Scan and MRM (RADAR)
Detector ** Low noise, off-axis, long-life photomultiplier** Low noise, off-axis, long-life photomultiplier** Low noise, off-axis, long-life photomultiplier** Low noise, off-axis, long-life photomultiplier**
Ion source transfer optics StepWave StepWave StepWave XS StepWave XS
MRM speed 555 MRM/ sec 555 MRM/ sec 500 MRM/ sec 500 MRM/ sec
Regulatory approval ***
Third-party software interfaces LIMS interface
MassLynx SkyLine interface
LIMS interface
MassLynx SkyLine interface
LIMS interface
MassLynx SkyLine interface
LIMS interface
MassLynx SkyLine interface
MassLynx security Yes Yes Yes Yes
Software options
  • MassLynx v4.2
  • waters_connect for Quantitation
  • MassLynx v4.2
  • waters_connect for Quantitation
  • MassLynx v4.2
  • waters_connect for Quantitation
  • MassLynx v4.2
  • waters_connect for Quantitation

* Not available with waters_connect
** Less than 1% of Waters’ tandem quadrupole mass spectrometers require a detector replacement on an annual basis. [Source: Waters’ internal data on the service history of its tandem quadrupole mass spectrometers launched between 2006 and 2022]
*** Regulated approval marks include CE, CB, NRTL (Canada/USA), RCM

Overview

  • Absolute Performance: Reach lower limits of quantitation to meet stringent regulatory requirements, with up to 15 times greater sensitivity for difficult-to-detect negative ionizing compounds compared to the previous product.
  • Absolute Efficiency: Enhance environmental sustainability and reduce operational costs with an instrument that consumes approximately 50% less electricity and gas, while generating 50% less heat than most high-performance TQ mass spectrometers currently available.
  • Absolute Confidence: Maintain long-term performance and productivity with consistent robustness and reproducibility.
  • Absolute Productivity: Enhance efficiency with flexible software solutions such as waters_connect—a modern, intuitive informatics platform that streamlines workflows, ensures data integrity, and can reduce data review time by up to 50%.

Recommended Use: Ideal for achieving lower limits of quantitation and meeting regulatory standards, even when analyzing challenging negative ionizing compounds.

Achieve Absolute Performance with Improved Sensitivity

An instrument with absolute performance is essential to achieve lower limits of quantitation and comply with regulatory standards, especially for challenging negative ionizing compounds. The Xevo TQ Absolute delivers up to 15 times greater sensitivity than its predecessor, enabling rapid and confident decision-making.

Xevo TQ Absolute provides significantly increased sensitivity, particularly for negative ion compounds such as polar pesticides.

Xevo TQ Absolute provides significantly increased sensitivity, particularly for negative ion compounds such as polar pesticides. Image Credit: Waters Corporation

Improve Sustainability and Lower Operational Costs

As organizations increasingly focus on environmental sustainability and cost reduction, the Xevo TQ Absolute provides a practical solution to support both goals. Engineered for lower electricity and gas consumption, along with reduced BTU/hr output, it helps decrease energy usage and air conditioning demands, resulting in lower operational costs. Its compact LC-MS/MS design maximizes analytical capability per square foot, enabling laboratory managers to optimize space utilization and enhance overall efficiency.

Waters Xevo TQ Absolute. Source: Waters Corporation

. .
Relative Bench Width 100%
Power Consumption 1460 W
Air Conditioning Demand (Heat Displacement) 4,980 Btu/h
Nitrogen/Zero-Grade Air Consumption 23 L/min
Audible Noise 59.2 dB

**Source: Xevo TQ Absolute Site Preparation Guide, power consumption range mid-point of 960 W + Ebara rough pump 500 W

SCIEX 7500. Source: Waters Corporation

. .
Relative Bench Width 184%
Power Consumption 3077 W
Air Conditioning Demand (Heat Displacement) 10,500 Btu/h
Nitrogen/Zero-Grade Air Consumption 52 L/min
Audible Noise 68 dB

*Source: Accessed January 2022 related to document RUO-IDV-01-9809-G SCIEX Triple Quad 7500 LC-MS/MS System - QTRAP Ready Site Planning Guide

Ensure Absolute Productivity with Flexible Software Options

Gain maximum flexibility in selecting the ideal quantitation solution with two powerful software platforms: waters_connect and MassLynx. The modern, app-based waters_connect platform offers enhanced efficiency and user experience, featuring Exception Focused Review (XFR) technology that can reduce data review time by up to 50%, helping to drive peak lab productivity. The well-established MassLynx software delivers trusted versatility and flexibility across a wide range of analytical needs.

The unique functionality of waters_connect for quantitation ensures your Xevo TQ Absolute provides absolute productivity.

The unique functionality of waters_connect for quantitation ensures your Xevo TQ Absolute provides absolute productivity. Image Credit: Waters Corporation 

Maintain Peak Performance Longer with Robustness and Reproducibility

With analytical laboratories navigating an array of evolving challenges, confidence in instrumentation that can keep pace is essential. The Xevo TQ Absolute is purpose-built to deliver long-term robustness and reproducibility, ensuring sustained performance and productivity. Optimal probe positioning minimizes contamination and reduces the frequency of cleaning-related downtime, while the newly designed source shield protects against contamination from sample matrices and mobile phase salts—helping laboratories maintain uptime and operational efficiency.

Minimize contamination and increase uptime with the new source shield technology featured in the Xevo TQ Absolute.

Minimize contamination and increase uptime with the new source shield technology featured in the Xevo TQ Absolute. Image Credit: Waters Corporation 

Accelerating Success with Award-Winning Service

Keep the laboratory running efficiently and prepared for future opportunities with Waters' comprehensive analytical solutions. Benefit from expert training through APS and take advantage of flexible, cost-effective options like FlexCHOICE for system servicing, along with trade-ins and technology upgrades through FlexUP to support business growth and keep the operations at the forefront of innovation.

Targeted Mass Spectrometry Imaging enables you to simply and quickly access lower limits of detection in molecular visualization directly from surfaces.

Targeted Mass Spectrometry Imaging enables you to simply and quickly access lower limits of detection in molecular visualization directly from surfaces. Image Credit: Waters Corporation

The new generation of Xevo.

The new generation of Xevo. Image Credit: Waters Corporation

Xevo TQ Absolute Fluidics.

Xevo TQ Absolute Fluidics. Image Credit: Waters Corporation

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