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Study provides a deeper understanding of how gene mutations contribute to breast cancer progression

A mutated gene found in more than 20% to 30% of breast cancer recurrences may help tumors become more aggressive and promote metastasis, according to a pair of new studies that uncover mechanisms behind these processes and point to new therapy targets.

From University of Pittsburgh 20 Apr 2022

New research shows significant variations in B-cells in women with PPD

Jerry Guintivano, PhD, of the University of North Carolina School of Medicine, led an exclusive transcriptome-wide association research that showed substantial changes in B-cells in women with postpartum depression, with pathway observations indicating modified B-cell activation and insulin resistance.

19 Apr 2022

Potential solution to make plants more tolerant lies in a single fatty acid

Climate change doesn't just mean warmer weather. Cold spells can hit unusual lows, too, and the fluctuations between warm and chilly are becoming more extreme.

13 Apr 2022

Duplicate genes in plant genomes, an eye-opener for crop development plans

When plant geneticists discover a gene that boosts crop yields, they want to see if they can replicate the effect in other crops.

1 Apr 2022

Study reveals genetically driven mucus pathobiology in asthma

A significant amount of genetic risk for asthma is likely mediated through altered gene expression within the airway epithelium.

29 Mar 2022

Adding a form of cellulose can prevent ice cream from becoming unpleasantly crunchy

Ice cream can be a culinary delight, except when it gets unpleasantly crunchy because ice crystals have grown in it.

21 Mar 2022

Microglia help neurons grow synapses critical to cognitive functioning, research finds

Microglia, the immune cells of the brain, are known for eating up unwanted items like germs and debris, much as their counterparts do in the rest of the body.

8 Mar 2022

Tadpoles with depleted microbiomes cannot cope with hot temperatures

In a warming world, animals could live or die by what's in their gut. That's one conclusion of a new study by Pitt biologists showing that tadpoles are less able to cope with hot temperatures without the help of microbes.

8 Mar 2022

Machine learning to explore large-scale relationships between vegetation and climatic characteristics

Climate change is causing more frequent and severe climatic extreme occurrences. However, it is still uncertain how future climatic extremes may affect vegetation distribution.

2 Mar 2022

Earlier onset of growing season in cold humid areas may benefit tree growth

A research group led by Prof. Liang Eryuan from the Institute of Tibetan Plateau Research of the Chinese Academy of Sciences has found that trees may benefit from an earlier start of the growing season in cold humid areas, but not in dry areas.

1 Mar 2022

Understanding mutational bias helps scientists predict how pathogens develop resistance to drugs

Genetic mutations help certain people succeed in the face of natural selection.

21 Feb 2022

Study reveals how a fly’s brain contributes to sensing the cold and limiting reproduction

Scientists have uncovered a set of neurons in fruit flies that shut down in cold temperatures and slow reproduction, a system conserved in many insects, including mosquitoes, which could provide a target for pest control.

18 Feb 2022

New vaccine providing protection against future animal-to-human viral diseases may be possible

A future vaccine providing protection against a wide range of coronaviruses that jump from their original animal hosts to humans -; including SARS-CoV-2, the cause of COVID-19 -; may be possible, say Johns Hopkins Medicine researchers, based on findings from their recent study.

17 Feb 2022

Novel immune deactivation pathway offers a promising therapeutic approach for cancers

Our immune systems have the potential to find and destroy cancer cells. But cancer cells can be clever and develop tricks to evade the immune system.

17 Feb 2022

High yield photochemical flow synthesis

The Borealis™ Flow Photoreactor from Uniqsis sets a new benchmark for high yield photochemical flow synthesis.

From Uniqsis Ltd 11 Feb 2022

Researchers decipher the genome of Steller’s sea cow from fossil bones

During the Ice Age, giant mammals such as mammoths, sabre-toothed cats and woolly rhinoceroses once roamed Northern Europe and America.

9 Feb 2022

Study discovers a novel role for hormone-sensitive neurons in maternal nesting behavior

Gestation leads to a modification of brain circuits and behaviors such as nesting within the animal kingdom. The underlying biological, neural and hormonal mechanisms have been unknown until now.

7 Feb 2022

Flavanols enhance browning of adipose tissue by activating the sympathetic nervous system

In cold conditions, brown adipose tissue (BAT) or brown fat generates heat to keep the body warm. Compared with white adipose tissue, BAT has more mitochondria-;subcellular organelles associated with energy production-;which allows it to burn calories and produce heat by activating the mitochondrial uncoupling protein 1 (Ucp-1).

3 Feb 2022

Study identifies new therapy to treat cystic fibrosis

The process of making proteins from genes is similar to that of a factory, where employees must follow a set of instructions that are both effective and precise.

31 Jan 2022

Omicron variant inefficient in causing diseases than other COVID-19 variants, study reveals

Scientists from the Department of Microbiology at the University of Hong Kong (HK) have found that the Omicron variant of SARS-CoV-2 replicates less efficiently and causes fewer diseases than other variants of COVID19.

27 Jan 2022