Inflammation News and Research

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LJI Researchers Identify Late-Rising T Cells Crucial for CMV Control

Cytomegalovirus (CMV) is a pathogen that likes to lurk. Most adults already carry CMV, and they show no symptoms at all.

22 Jan 2024

Stem Cell-Derived Brain Organoids on Ax-3 Mission Seek to Improve Modeling for Neurodegenerative Diseases

More than 5 million people worldwide are living with neurodegenerative disorders like Parkinson’s disease and primary progressive multiple sclerosis (PPMS).

19 Jan 2024

Breakthrough 3D Vascular Sheet Mimics Atherosclerosis for High-Throughput Drug Screening

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

16 Jan 2024

Live-Cell Imaging Reveals How STING Activates Innate Immunity

When pathogens attack the body, the innate immune system goes to work protecting against the invading disease.

12 Jan 2024

Key Cytokine Pairs Driving Sepsis Damage Identified

One of the main causes of death in the ICU is sepsis, which is the result of an infection that causes the immune system to mistakenly target the body.

9 Jan 2024

Study Reveals Tissue-Specific Effects of JAK1 Signaling in Inflammation

Researchers at the Icahn School of Medicine at Mount Sinai have gained a deeper understanding of the nuanced roles of JAK inhibitors, or modulators, in inflammation across various cell types and tissues.

26 Dec 2023

Researchers Uncover Previously Unknown Inactive Form of p38a Protein

p38a protein, a key enzyme in the regulation of various cellular functions, plays a crucial role in some diseases, including cancer, chronic inflammation, and neurodegenerative conditions.

20 Dec 2023

Omicron's Cellular Senescence May Explain Cytokine Storms and Long-COVID

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Uncovering a unique pathogenic mechanism of SARS-CoV-2 omicron variant: selective induction of cellular senescence."

18 Dec 2023

Tailored Nanoparticles Deliver siRNA to Reduce Neuroinflammation in Alzheimer's Disease Models

Some Covid-19 vaccines safely and effectively used lipid nanoparticles (LNPs) to deliver messenger RNA to cells.

11 Dec 2023

Unveiling the Role of EVs in Bacterial Communication and Immune Surveillance

Messenger bubbles produced by human cells can pick up bacterial products and deliver them to other cells, University of Connecticut researchers report in the Nov. 16 issue of Nature Cell Biology.

28 Nov 2023

Rethinking Antibiotics: Dental Professionals Embrace New Alternatives For Standard Dental Procedures

Bacterial resistance to antibiotics poses a threat to global health, and the WHO highlights the consequences of inappropriate and excessive antibiotic use.

22 Nov 2023

LJI Scientists Uncover New Superpower of MAIT Cells

Scientists at La Jolla Institute for Immunology (LJI) are investigating a talented type of T cell.

13 Nov 2023

Rising Prevalence of Chronic Rhinosinusitis in Japan: Causes and Implications

Chronic rhinosinusitis (CRS) is an inflammatory condition affecting the nasal cavity and sinuses, which can be categorized into eosinophilic and non-eosinophilic subtypes.

7 Nov 2023

Research Reveals How Gut Bacteria Influence Distant Organs Through Oxytocin Signaling

The gut microbiome, a community of trillions of microbes living in the human intestines, has an increasing reputation for affecting not only gut health but also the health of organs distant from the gut.

3 Nov 2023

Exploring the Probiotic Potential of Fungi in Food Production

As detailed in a recent study, two fungi employed in food production exhibit promising probiotic properties that could help alleviate gut inflammation. This research sheds light on a potential avenue for creating novel probiotics.

27 Oct 2023

Scientists Develop Novel Glycoengineering Platform to Revolutionize Vaccine and Therapeutic Production

A novel glycoengineering platform, created by the laboratory of Assistant Professor Chris Lok-To Sham from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), is poised to revolutionize future production of vaccines and therapeutics to fight infectious diseases.

17 Oct 2023

MIT Chemists Discover Structure of SARS-CoV-2 Ion Channel in Open State

The genome of the SARS-CoV-2 virus encodes 29 proteins, one of which is an ion channel called E. This channel, which transports protons and calcium ions, induces infected cells to launch an inflammatory response that damages tissues and contributes to the symptoms of Covid-19.

16 Oct 2023