Enzyme News and Research

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Accelerating Enzyme Discovery With the SMART Single-Molecule Screening System

Enzymes are proteins that catalyze chemical reactions in living organisms. They are widely applied in industries such as food production, detergents, pharmaceuticals, and chemicals.

30 Apr 2026

Fragment-Based Drug Design Accelerates Efficient Discovery of New Medicines

Modern medicine has played a significant role in improving the length and quality of our lives. While many treatments may seem like miracles, they are the result of a lengthy, rigorous research process.

24 Apr 2026

Stress Response in Polyploid Cells Fuels Cancer Progression

One of the biggest challenges in cancer research is understanding why some tumor cells become especially aggressive, invasive and resistant to treatment.

24 Apr 2026

New Methods Increase Understanding of How Bacteria Manage DNA

New analytical methods developed at Baylor College of Medicine and collaborating institutions have increased our understanding of how bacteria manage DNA.

23 Apr 2026

Study Reveals the "Black Box" of Protein Quality Control in the ER

Over the past few years, Kivanç Birsoy of Rockefeller University and his colleagues in the Laboratory of Metabolic Regulation and Genetics have uncovered amazing information about the antioxidant glutathione, which has numerous vital functions in the body, including eliminating free radicals and repairing cellular damage.

20 Apr 2026

Protein Shape Changes Come Into Focus With LiP-MS and 3D Proteomics

This review explains how LiP-MS detects protein structural changes across whole proteomes, adding functional insight that standard abundance-based proteomics often misses. It also surveys method variants and shows how LiP-MS supports drug-target discovery, disease biomarker research, and the broader framework of “3D proteomics.”

20 Apr 2026

Redefining Cancer Therapy Through Selective Targeting of BET Protein Families

For over a decade, a class of drugs called BET inhibitors has been tested in cancer trials with high expectations.

10 Apr 2026

Chemical Strategy Unlocks Pollutant Degradation Potential in Native Soil Bacteria

Aromatic compounds, such as dioxins and benzene, are major soil pollutants. Their high chemical stability makes them resistant to microbial and chemical degradation, leading to toxic accumulation in the soil.

10 Apr 2026

Study Reveals Pol Theta Role in Cancer DNA Repair

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential than researchers realized.

8 Apr 2026

Novel ENDOtollins Block Harmful Inflammation While Preserving Infection Response

Scripps Research scientists have developed a new class of drug compounds that reduce harmful inflammation while leaving the body's ability to fight infections intact-a long-sought goal in treating autoimmune diseases.

7 Apr 2026

Study Maps Cellular Pathways Essential for Metaplasia and Precancerous Lesions in the Pancreas

Pancreatic ductal adenocarcinoma is the most common type of pancreatic cancer and has a low five-year survival rate.

6 Apr 2026

How Bacterial Enzymes Use Ratchet Mechanisms to Break Down Collagen

Collagen is an important protein that helps build the tissues of humans and animals. It is very strong because it is made of three protein strands twisted tightly together like a rope. Because of this sturdy structure, ordinary protein-cutting enzymes usually cannot break it down.

6 Apr 2026

Excessive RNA Editing May Explain Neurological Differences in Down Syndrome

A collaborative research study co-led by scientists at the Icahn School of Medicine at Mount Sinai and the Liber Institute for Brain Development has for the first time identified a biological process that may help explain how the brain develops differently in people with Down syndrome. The study was a collaboration among scientists from the Icahn School of Medicine at Mount Sinai, the Lieber Institute for Brain Development, the Medical University of Sofia in Bulgaria, and the University of Arizona.

2 Apr 2026

Cysteine Pathways Shape T Cell Expansion and Cancer Defense

A research team from the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Bloomberg School of Public Health have discovered how the immune system's CD8+ T cells use the nutrient cysteine to control two essential functions that compete for this resource - the immune cell's ability to multiply and its ability to kill cancer cells.

1 Apr 2026

Biodegradable Plastic Byproducts Impair Fetal Growth in Mouse Study

When the "eco-friendly" bioplastic, polylactic acid (PLA), biodegrades, the resulting nanoplastics can accumulate in the fetuses of pregnant mice and interfere with fetal growth. Yichao Huang and De-Xiang Xu of Anhui Medical University, China, and Mingliang Fang of Fudan University, China, report these findings in a new study published March 26th in the open-access journal PLOS Biology.

28 Mar 2026

Microtubules Act as Active Regulators of Key Cellular Enzymatic Reactions

Microtubules, the dynamic filaments that form the cell's internal scaffolding, have long been viewed as mere passive structural supports. But a new study reveals they play a far more active signaling role.

27 Mar 2026

Newly Discovered CRISPR System Activates Genes Without Cutting DNA

In back-to-back studies published in Nature, researchers from Purdue University and Columbia University report a naturally evolved gene-editing system that can activate genes, offering an advantage over existing CRISPR gene-editing systems that merely find and cut DNA.

26 Mar 2026