Enzyme News and Research

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PI3K Enzyme's Dual Accelerator and Brake Mechanisms Uncovered

A group of researchers have expanded conventional knowledge on a critical enzyme that controls cell migration. In a recent publication in the journal Nature Communications, they reported that phosphoinositide 3-kinase (PI3K) not only acts as an accelerator to prompt cell motility, but it also has a built-in brake mechanism that impedes migration.

25 Apr 2024

Using State-of-the Art Imaging to Understand Lipid Dysfunction in Alzheimer's

Alzheimer's disease causes significant problems with memory, thinking and behavior and is the most common form of dementia, affecting more than 50 million people around the world each year.

24 Apr 2024

Study Uncovers Cells' Surprising Strategy to Control Signaling Pathways

Healthy cells respond appropriately to changes in their environment. They do this by sensing what's happening outside and relaying a command to the precise biomolecule in the precise domain that can carry out the necessary response.

23 Apr 2024

Revealing the Genetic Mechanisms Driving SARS-CoV-2 Variants

The SARS-CoV-2 virus, responsible for COVID-19, exhibits a troubling tendency to produce variants frequently.

23 Apr 2024

U of T Scientists Make Breakthrough Discovery in DNA Repair Mechanism

Researchers at the University of Toronto have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and premature aging.

18 Apr 2024

What Makes Certain Mushrooms 'Magic'?

In a recent study published in the journal Nature Communications, an international research team from various Universities including Hans Knöll Institute investigated the biosynthesis of psilocybin, the primary component of hallucinogenic mushrooms.

17 Apr 2024

Newly discovered mechanism identified in the initial stages of Alzheimer's disease

Alzheimer's disease (AD) continues to be one of the most difficult and common neurodegenerative diseases, impacting millions of people globally.

16 Apr 2024

Can Pets Harbor and Spread Antibiotic-Resistant Bacteria?

According to new research, pet dogs and cats are major contributors to the spread of bacteria resistant to antibiotics.

15 Apr 2024

Study Reveals How Cells Recycle Proteins in Response to Nutrient Starvation

A new study details how nutrient-starved cells divert protein transport stations to cellular recycling centers to be broken down, highlighting a novel approach cells use to deal with stressful conditions.

15 Apr 2024

Unraveling the Molecular Mechanisms of DNA Entanglement Resolution

Picture in your mind a traditional "landline" telephone with a coiled cord connecting the handset to the phone.

12 Apr 2024

Different Chromosomes Found to Have Separate End-Specific Telomere-Length Distributions

We depend on our cells being able to divide and multiply, whether it's to replace sunburnt skin or replenish our blood supply and recover from injury.

12 Apr 2024

New Method Revolutionizes Assessment of Ferroptosis-Targeting Enzymes

New research could pave the way to develop cancer drugs targeting an enzyme that inhibits ferroptosis, a type of cell death.

8 Apr 2024

Study Reveals Structure of Two Nucleic Acid-Degrading Enzymes

When nucleic acids like DNA or RNA build up in a cell's cytoplasm, it sets off an alarm call for the immune system.

3 Apr 2024

Study Reveals Insights into Evolution of Regulatory Proteins

New research from the University of Wisconsin–Madison decodes the evolutionary pathway of regulatory proteins, the molecules that help control gene expression.

1 Apr 2024

Enzymatic Cocktail Outperforms Antibiotics Against Mycobacteria, Including TB

A recent study published in Microbiology Spectrum, a journal of the American Society for Microbiology, demonstrates that an enzymatic cocktail has the capability to eliminate various mycobacterial species of bacteria, including those responsible for tuberculosis.

28 Mar 2024

Nature-Inspired Approach Accelerates Folding of Cysteine-Rich Peptides for Drug Discovery

Certain types of peptides and microproteins for drug discovery research can be made more efficiently and quickly using a reaction solvent that helps mimic nature's way.

25 Mar 2024

U of T Researchers Develop Groundbreaking Platform for Protein-Based Disease Treatment

Researchers at the University of Toronto and Sinai Health have created a new platform to identify proteins that can be co-opted to control the stability of other proteins -; a new but largely unrealized approach to the treatment of disease.

25 Mar 2024

Cells Harvested From Urine May Have Diagnostic Potential for Kidney Disease

Genes expressed in human cells harvested from urine are remarkably similar to those of the kidney itself, suggesting they could be an important non-invasive source of information on the kidney.

20 Mar 2024

Targeting T Cell Metabolism to Boost Cancer Therapies

Recent findings from the lab of Jessica Thaxton, PhD, MsCR, in the UNC School of Medicine's Department of Cell Biology and Physiology, as well as associates in the Lineberger Comprehensive Cancer Center's Immunotherapy Group, have provided new insights into T-cell metabolism that may improve immunotherapies that depend on T cells to combat cancer.

18 Mar 2024

Baby Gut Bacteria Found to Play Crucial Role in Immune Development

Researchers at Weill Cornell Medicine have shown that certain bacteria invade the stomach soon after birth and produce serotonin, a neurotransmitter that helps teach gut immune cells.

18 Mar 2024