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First Fully Synthetic Bacteriophage Engineering System for Antibiotic-Resistant Bacterium

Bacteriophages have been used therapeutically to treat infectious bacterial diseases for over a century.

21 Jan 2026

Replacing Large Mouse Gene Regions with Human DNA

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes with entire human sequences has posed significant technical challenges.

19 Jan 2026

Backyard Soil Bacterium Produces Antibiotic Built to Outsmart Resistance

Early in 2025, scientists discovered a promising new antibiotic in a soil sample from a lab technician's backyard.

16 Jan 2026

Intelectin-2: A Dual-Action Lectin Fortifies Gut Barrier and Fights Bacteria

The mucosal surfaces that line the body are embedded with defensive molecules that help keep microbes from causing inflammation and infections.

14 Jan 2026

New Pangenomic Approach Enables Unprecedented Scaling for Genetic Data

Researchers at the University of California have created a novel data structure and compression method that allows pangenomics to process genetic information at previously unattainable scales.

14 Jan 2026

Giant Virus with A Massive Genome and Unusual Infection Strategy

Ushikuvirus, a newly identified giant virus, showcases unique cytopathic effects and structural features, enhancing knowledge of viral evolution and diversity.

14 Jan 2026

Giant Virus Uses Unique Codon Strategy to Optimize Host Resource Usage

A virus relies on the host's translation machinery to replicate itself and become infectious. Translation efficiency partially depends on the usage of a codon, or sequence of three nucleotides, that matches the cellular pool of tRNA, key molecules in translation.

12 Jan 2026

Ancient WUS Genes and Expression Thresholds Shape Shoot Regeneration

Unlike animals, plants generate most organs after embryogenesis through stem cell–driven meristems, enabling lifelong growth and regeneration.

9 Jan 2026

Genetic Study Links Expanding DNA Repeats to Aging and Disease Risk

An analysis of genetic data from over 900,000 people shows that certain stretches of DNA, made up of short sequences repeated over and over, become longer and more unstable as we age.

8 Jan 2026

Synthetic Biology and Metabolic Engineering Drive Microbial L-Tryptophan Biomanufacturing

This review synthesizes progress in pathway optimization, regulatory rewiring, and microbial cell factory design that has driven L-Trp titers to industrially relevant levels while enabling the biosynthesis of downstream products ranging from neurotransmitters and plant hormones to dyes and complex alkaloids.

8 Jan 2026

High-Tech Imaging Unlocks Genetic Secrets Of Nutrient-Rich Seeds

By rapidly analyzing nearly 12,000 individual seeds, the approach uncovers genetic loci that simultaneously influence seed morphology and mineral composition, opening new avenues for crop biofortification and safer food production.

7 Jan 2026

LINE-1 Retrotransposons Reshape Cancer Genome Architecture

Scientists at St. Jude Children's Research Hospital have revealed previously unappreciated roles for the retrotransposon LINE-1 in shaping the cancer genome structure and regulation.

6 Jan 2026

Study Resolves Ancient Genome Duplication History of Flowering Plants

Angiosperms, also known as flowering plants, represent the most diverse group of seed plants, and their origin and evolution have long been a central question in plant evolutionary biology.

5 Jan 2026

New CHANGE-seq-BE Method Sharpens Safety Assessment of CRISPR Base Editors

Scientists and physicians can better assess precision genome editing technology using a new method made public today by St. Jude Children's Research Hospital.

5 Jan 2026

Mapping Two Millennia of Betaherpesvirus Evolution via Ancient Human Genomes

Researchers have successfully reconstructed the ancient genomes of Human betaherpesvirus 6A and 6B (HHV-6A/B) from human remains that are over two thousand years old.

5 Jan 2026

Base-Pair Resolution Benchmark Uncovers Structural Variation Complexity in Tomato Genomes

Structural variations (SVs), including insertions, deletions, inversions, and substitutions, can profoundly influence gene regulation and phenotype.

2 Jan 2026

Genetic Factor "Fru" Influences Bees' Cooperative Food-Seeking Behavior

A team of biologists from Heinrich Heine University Düsseldorf (HHU), along with researchers from Bochum and Paris, has uncovered a genetic component underlying intricate social behaviors in bees.

24 Dec 2025

Mapping the Four Dimensional Organization of the Human Genome

A new study challenges what's long been assumed about genetic variants thought to always cause inherited blindness.

23 Dec 2025

Protein MCL1 Emerges as a Central Regulator of Cancer Metabolism

The researchers have succeeded in tracing two classic hallmarks of cancer – the evasion of apoptosis (a form of programmed cell death) and the dysregulation of energy metabolism – back to a common molecular mechanism.

23 Dec 2025

Foreign RsMYB28 Allele Boosts Glucosinolate Accumulation in Rapeseed

These bioactive compounds, found primarily in Brassicaceae plants, play crucial roles in plant defense, contribute to distinctive food flavors, and have potential health benefits, including cancer prevention.

23 Dec 2025