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Genetic Study Reveals Biological Drivers of Frailty in Aging

Researchers at McMaster University have identified, for the first time, a novel region of DNA and two associated genes connected to frailty, offering neurological and immune-related insights that might help explain why some older adults are more likely to be frail than others.

22 Apr 2026

Molecular Keyhole Discovery Unlocks New Target for Pain Therapies

Researchers at VIB, VUB, and KU Leuven have identified a tiny binding site, a molecular 'keyhole', in the TRPM3 ion channel, a crucial sensor in pain signaling.

22 Apr 2026

How Mitochondrial Damage Accelerates Stem Cell Aging

Hematopoietic stem cells (HSCs), the cells that produce all blood cell types, start to lose their efficacy as one ages, which eventually reduces the ability to maintain healthy blood and a robust immune system.

17 Apr 2026

"Zombie" Macrophages Accumulate in Aging Tissues and Diseased Livers

UCLA researchers have identified a rogue population of immune cells that quietly accumulates in aging tissues and in the livers of people with fatty liver disease. Clearing these cells, they found, dramatically reduced inflammation and reversed liver damage in mice - even while the animals remained on an unhealthy diet.

16 Apr 2026

Cryo-Electron Microscopy Reveals Structure of Borna Virus RNA Protein Complex

Cases of Borna disease virus 1, or BoDV-1, are extremely rare in humans, but in those who develop disease the outcome is severe, almost always resulting in fatal encephalitis or inflammation in the brain.

13 Apr 2026

CIPHER-seq Reveals RNA and Protein Activity in Immune Cells

A new single-cell technology is giving scientists their clearest view yet of immune cell behavior-capturing not just genetic intent but real-time activity.

9 Apr 2026

Semen-Derived Exosomes Eye Drops to Treat Retinoblastoma

Innovative eye drops using semen-derived exosomes target retinoblastoma, improving therapeutic delivery and preserving ocular function in preclinical models.

8 Apr 2026

ASHOP Platform Unifies Multi-Omics Data for Blood Cancer Insights

Scientists at St. Jude Children's Research Hospital, the American Society for Hematology (ASH) and the Munich Leukemia Laboratory have developed a data-sharing platform that unites genomics, gene expression and clinical information from nearly 6,000 patients with blood cancers.

7 Apr 2026

New Mouse Model Reveals Viral Path to Liver Cancer

Liver cancer is one of the world's deadliest cancers, and most cases are linked to chronic viral hepatitis. Yet scientists have lacked an animal model that faithfully recapitulates how the disease unfolds in people, from initial infection with a virus to liver inflammation, scarring, and cancer.

7 Apr 2026

Novel ENDOtollins Block Harmful Inflammation While Preserving Infection Response

Scripps Research scientists have developed a new class of drug compounds that reduce harmful inflammation while leaving the body's ability to fight infections intact-a long-sought goal in treating autoimmune diseases.

7 Apr 2026

Study Maps Cellular Pathways Essential for Metaplasia and Precancerous Lesions in the Pancreas

Pancreatic ductal adenocarcinoma is the most common type of pancreatic cancer and has a low five-year survival rate.

6 Apr 2026

Study Highlights Unexpected Role of Stard7 in Colorectal Cancer Development

A new study led by researchers at the University of Liège highlights the unexpected role of Stard7 in the development of intestinal cancers.

3 Apr 2026

Defining Tumor Microbiota for Improved Cancer Diagnosis and Treatment

Recent research shows that tumors in different organs host microbial communities capable of influencing cancer biology, immune responses, and the effectiveness of therapies, highlighting the need to standardize methods for studying intratumoral microbes.

3 Apr 2026

Researchers Use Retron Systems to License DNA for Cellular Tasks

Stepping away from its billions-of-years-old role as a genetic "blueprint," DNA is now embarking on a new journey as an active "field agent" within cells. This research by a team led by Professor Jongmin Kim and Ph.D. candidate Geonhu Lee from the Department of Life Sciences at POSTECH (Pohang University of Science and Technology) was published in the online edition of the international chemistry journal, Nature Chemistry.

2 Apr 2026

Nonviral Nanoparticles Show Promise for Safer Gene Delivery Methods

In a demonstration that helps pave the way for gene therapies with fewer side effects, several human cell types were genetically modified with protein nanoparticles designed at University of Michigan Engineering and Michigan Medicine.

1 Apr 2026

How To Create Long-Lasting Immune Cells For Stronger Vaccines

Scientists at the University of Wisconsin School of Veterinary Medicine have identified a potential approach to develop longer-lasting vaccines for respiratory viruses such as influenza and the coronavirus that causes COVID-19.

1 Apr 2026

Novel Immunotherapy Disrupts the Protective Tumor Microenvironment Ecosystem

Chimeric antigen receptor T-cell therapy - CAR T for short - has been a major advance in treating blood cancers like leukemia and lymphoma. But the immunotherapy has struggled against solid tumors for two main reasons: tumor cells often don't share one consistent surface target, and many solid tumors are protected by a dense network of scar tissue and immune-suppressive cells that blocks T cells.

31 Mar 2026