therapeutics News and Research

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Modulating T Cell Exhaustion Offers Novel Therapeutic Pathways in Transplantation

A comprehensive new review examines the complex role of T cell exhaustion in organ transplantation, highlighting how this dysfunctional immune state can both promote graft tolerance and create vulnerabilities to infection and malignancy.

7 Aug 2026

Study Offers New Perspective on How Phase Separation Contributes to Gene Regulation

A research team from AIST, the Institute of Science Tokyo, and Ritsumeikan University has demonstrated that the phase behavior of histone–DNA condensates depends on the site of histone acetylation.

6 Aug 2026

Tireless Stem Cells Drive Continuous Renewal Across High Friction Human Intestines

Digestion is hard on the cells that line the human gut, and they are constantly being shed and replaced. This renewal is driven by a population of tireless stem cells. These stem cells can both replace the various types of intestinal cells that have been lost as well as renew themselves.

6 Aug 2026

Stable RNA Structures Revolutionize Quality of Life in Oncology Care

A new review highlights the growing importance of circular RNAs (circRNAs) in addressing one of the most pressing challenges in modern oncology: treatment-related toxicity.

6 Aug 2026

Shuttling Gene Activating Proteins Through Packed Histones Treats Neurodegenerative Disease

Cells can switch off genes by tightly packaging DNA around proteins called histones.

6 Aug 2026

Dynamic Structural Flexibility of Human Norovirus Evade the Immune System

Human norovirus is the leading cause of acute gastroenteritis worldwide and is estimated to infect 600–700 million people each year. Despite its enormous public health impact, no effective antiviral drugs are currently available.

5 Aug 2026

Mapping Spatial Genome Architecture Unlocks Hidden Biological Mechanisms Behind Genetic Risk

Much of how genetic risk leads to disease has remained hidden. In many cases, genetic variants linked to disease do not act on nearby genes along the chromosome. Instead, they influence genes located far away along the DNA sequence.

5 Aug 2026

T Cells Identify Dangerous Pathogenic Threats to Keep Bodies Healthy

Your body depends on T cells to stay healthy. These white blood cells act like a neighborhood watch in the body, helping the immune system spot threats such as viruses, bacteria, and cancer cells.

3 Aug 2026

Structure-Guided Protein Engineering Unlocks Safer Methods for Gene Therapy

A joint research team led by Professor Daesik Kim (Department of Medicine, Sungkyunkwan University), along with Professor Yong-Sub Kim (University of Ulsan College of Medicine) and Professor Jae-Hyun Park (Sungkyunkwan University School of Medicine), has announced the development of 'OpenABE' (Open Adenine Base Editor).

31 Jul 2026

New Method Enables Faster Oxidation-Free Oligonucleotide Synthesis

Oligonucleotide synthesis is fundamental to genetic analysis, biological research, and nucleic acid therapeutics.

30 Jul 2026

New Framework Uses Genetic Variant Data to Recall Biobank Participants

Clinical biobanks that combine genomic data with electronic health records (EHRs) have become powerful resources for discovering genetic variants associated with disease.

28 Jul 2026

Novel Dendritic Cell Vaccine Redirects Viral Memory to Fight Tumors

In a discovery that could redefine the future of cancer immunotherapy, scientists from Celloram Inc., University Hospitals and Case Western Reserve University have developed a novel cancer vaccine platform that transforms the impact of the largest immunological event in modern history

28 Jul 2026

Elevated Levels of Acid Ceramidase Make Zombie Cells Susceptible to Ferroptosis

Our population is aging. The United Nations reports that by 2050, the number of people over the age of 85 on our planet is set to triple.

24 Jul 2026

Study Reveals How Genome Regulation Changes During Brain Aging

Researchers have discovered that the human brain undergoes widespread age-related changes in genome regulation beginning in midlife that may help explain why aging is the greatest risk factor for neurodegenerative diseases such as Alzheimer's.

24 Jul 2026

Researchers Find New Bacterial Mechanism for Evading Antibiotic Exposure

Antibiotics are a medical marvel, but many microbes are gaining the ability to resist and tolerate these therapeutics.

24 Jul 2026

Changes in RNA Regulation Enable Bacteria to Enter Antibiotic Tolerance

Antibiotics are a medical marvel, but many microbes are gaining the ability to resist and tolerate these therapeutics. St. Jude Children's Research Hospital scientists have uncovered how S. pneumoniae adapts to antibiotic exposure and immune pressures.

23 Jul 2026

New Open Source AI Toolkit Identifies Promising Peptide Medicines

Penn Engineers have developed PeptiVerse, an AI-powered platform that predicts key chemical and biological properties of peptides, the strings of amino acids whose medical potential has been demonstrated by the success of GLP-1 drugs, the widely used weight-loss treatments.

22 Jul 2026

Demographic Biases Threaten the Fairness of Global Single-Cell Human Atlases

The single-cell "atlases" that are increasingly used to map the human body and as training data for artificial intelligence models, may not represent the world's populations fairly, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai.

21 Jul 2026

Innovative Bioelectronic Ear Devices Offer New Hope for Asthma Relief

Neuroimmunology, the study of interactions between the nervous and immune systems, is a rapidly growing field enabling new approaches for monitoring and treating inflammatory diseases.

16 Jul 2026

New CRISPR Atlas Details How Every Gene Influences Stem Cells

A team led by bioengineers at the University of California San Diego has developed a genome-scale reference map that details how individual genes control the functions and identities of human stem cells.

14 Jul 2026