Inflammation News and Research

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Increased expression of DUSP16 molecule leads to cancer chemoresistance

Chemotherapy is a drug treatment that uses powerful chemicals to kill fast-growing cancer cells in the body. It is a systemic treatment where drugs travel throughout the body and destroy cancer cells that have spread (metastasized) to parts of the body far away from the original (primary) tumour.

28 Apr 2021

Study shows a possible link between pesticide exposure and increased COVID-19 susceptibility

Researchers have discovered a possible connection between increased vulnerability to COVID-19 infection and exposure to organophosphate pesticides.

27 Apr 2021

Low-dose administration of MERS DNA vaccine protects against COVID-19

The Wistar Institute has developed a synthetic DNA vaccine candidate for Middle East respiratory syndrome coronavirus (MERS-CoV).

26 Apr 2021

Study finds raised levels of specific immune cells in asymptomatic people with COVID-19

The largest study of its type in the UK has identified differences in the immune response to COVID-19, between people with no symptoms, compared to those suffering a more serious reaction to the virus.

21 Apr 2021

Chemical biomarker levels reflect varying severity of COVID-19 symptoms

Varying severity of COVID-19 symptoms in patients is reflected by levels of a chemical biomarker in their body which scientists say could be used to better manage treatments and other interventions, including vaccinations.

20 Apr 2021

3D biomaterial helps implanted stem cells stick around to reverse arthritis

A 3D biomaterial scaffold design to slowly release stem cells has worked to ensure implanted stem cells stick around to relieve pain and reverse arthritis in mice knee joints.

19 Apr 2021

Gene therapy protects eye cells in mice with retinitis pigmentosa

A gene therapy protects eye cells in mice with a rare disorder that causes vision loss, especially when used in combination with other gene therapies, shows a study published today in eLife.

15 Apr 2021

Study shows that neural stem cells age quickly

A research team has revealed that neural stem cells (NSCs)—that is, the stem cells of the nervous system—age quickly.

14 Apr 2021

A new way to predict positive outcomes of immunotherapy in patients with bladder cancer

Researchers have detected and validated groups of genes linked to immunotherapy resistance in patients with metastatic urothelial cancer of the bladder.

12 Apr 2021

Warped immune cell signaling during bile acid exposure may lead to Crohn’s disease

People with Crohn's disease are typically treated with powerful anti-inflammatory medications that act throughout their body, not just in their digestive tract, creating the potential for unintended, and often serious, side effects.

8 Apr 2021

Novel, non-invasive biomarker test could help measure, track performance of senolytics

Scientists from Buck Institute have identified and are now developing an innovative, non-invasive biomarker test that could help quantify and track the performance of senolytics—a class of drugs that selectively destroy senescent cells.

5 Apr 2021

Experimental antibody therapies for neurodegenerative diseases may lead to brain inflammation

A research team has made a novel finding that indicates that experimental antibody treatments for Alzheimer’s disease have an accidental adverse impact.

31 Mar 2021

Strong cell-cell junctions preserve the quiescent properties of stem cells

The skin is known to be the largest organ in the human body, and its outermost layer, called the epidermis, is renewed every three weeks.

29 Mar 2021

Key molecule determines the pathogenesis of lupus

A new research work, published in JCI, has discovered that the endoplasmic reticulum of a neutrophil becomes stressed in the autoimmune disorder lupus.

29 Mar 2021

Study shows how WAVE2 protein maintains the immune system balance

Sinai Health researchers have reported that they have uncovered a new mechanism that regulates harmful overreactions in the body’s immune system.

26 Mar 2021

Study shows how a subset of T cells is generated in melanoma survivors affected by vitiligo

A few patients suffering from melanoma are known to respond quite well to immunotherapy and experience significant and long-lasting tumor regression.

25 Mar 2021

Scientists generate a detailed molecular atlas of lung development

Researchers at the Perelman School of Medicine at the University of Pennsylvania have produced a detailed molecular atlas of lung development, which is expected to be a fundamental reference in future studies of mammalian biology and of new treatments for diseases, such as COVID-19, that affect the lungs.

25 Mar 2021

Stem cell therapy could help restore debilitating muscle loss that happens with age

As the name implies, induced pluripotent stem cells can become any type of cell in our body, and scientists have evidence that when they prompt them to become muscle progenitor cells they can help restore the sometimes debilitating muscle loss that happens with age.

24 Mar 2021

Disease-driving B cells play a role in non-alcoholic fatty liver disease

A study by researchers proposes that disease-driving B cells—a kind of white blood cell—have a role in the development of non-alcoholic fatty liver disease.

23 Mar 2021

Study reveals mechanism by which ibuprofen prevents RAC1B alternative splicing in colorectal cells

Oncotarget published "Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells" which reported that although the molecular mechanism behind the antitumor properties of NSAIDs has been largely attributed to inhibition of cyclooxygenases , several studies have shown that the chemopreventive properties of ibuprofen also involve multiple COX-independent effects.