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Novel Replacement Strategy Opens the Door to Therapeutic Interventions for Genomic Diseases

Severe Combined Immunodeficiencies (SCIDs) are a group of debilitating primary immunodeficiency disorders, primarily caused by genetic mutations that disrupt T-cell development.

27 Oct 2023

Software Tool Paves the Way for Safer CRISPR Genome Editing

Researchers have developed a groundbreaking software tool known as DANGER analysis, offering a solution for safer and more precise genome editing.

23 Oct 2023

Revealing How Interferon-Gamma Stops Tumor Cell Growth

At the UCLA Jonsson Comprehensive Cancer Center, scientists have uncovered a novel function for a protein known as extracellular signal-regulated kinase (ERK) within a pathway activated by interferon-gamma, capable of inducing cellular self-destruction.

11 Oct 2023

Modifying/Shredding RNA with Small 3D CRISPR Model

Small and precise: these are the perfect traits for CRISPR systems, the Nobel Prize-winning technology used to alter nucleic acids such as RNA and DNA.

28 Sep 2023

How Scientists are Using iPSCs to Develop New Therapies

In 1998, scientists reported being able to derive cells from human embryos that could develop into almost any cell in the body. In 2007, the field took a huge leap when scientists discovered they could reprogram human adult skin cells to act like these embryonic stem cells.

20 Sep 2023

Broken String Biosciences Closes $15M Series A Funding Round

Broken String Biosciences today announced that it has closed a $15 million Series A investment round, co-led by Illumina Ventures and Mérieux Equity Partners, with contributions from HERAN Partners, and existing investors Tencent and Dieter von Holtzbrinck Ventures.

19 Sep 2023

NICER Gene Editing Technique Reduces Unintended Mutations

The gene editing technique CRISPR/Cas9 has allowed researchers to make precise and impactful changes to an organism's DNA to fix mutations that cause genetic disease.

15 Sep 2023

Pusan National University Scientists Explore OsMATL2 Gene as a Candidate for Haploid Induction in Rice

Double haploid technology can dramatically accelerate crop breeding with specifically chosen genetic traits.

13 Sep 2023

Single Injection of CRISPR Gene-Editing Treatment Safely Removes SIV From Non-Human Primates

A single injection of a novel CRISPR gene-editing treatment safely and efficiently removes SIV – a virus related to the AIDS-causing agent HIV – from the genomes of non-human primates, scientists at the Lewis Katz School of Medicine at Temple University now report.

17 Aug 2023

New Gene Editing Technique Reduces Chalkiness in Rice

As global temperatures continue to rise, maintaining the quality and yield of crops adapted to lower temperatures will increasingly become a challenge.

31 Jul 2023

New Proof-of-Concept Model for Delivering Gene Editing Tools to Treat Blood Disorders

In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body.

28 Jul 2023

New Culture System may Improve Efficiency and Safety of Genome Editing in HSCs

Hematopoietic stem cells (HSCs) are rare cells found in the bone marrow that produce red blood cells, white blood cells, and platelets.

11 Jul 2023

Researchers Develop New Way to Genetically Suppress Malaria-Carrying Mosquitoes

Malaria remains one of the world's deadliest diseases. Each year malaria infections result in hundreds of thousands of deaths, with the majority of fatalities occurring in children under five.

6 Jul 2023

Deep Learning Model Accurately Predicts RNA-Targeting CRISPR Activity

According to new research published in Nature Biotechnology, artificial intelligence can predict on- and off-target behavior of CRISPR tools that target RNA rather than DNA.

5 Jul 2023

Genetically Modified iPS Cell Applications for Fabry Disease

iPS cells have had a significant impact on biology and medicine, and they are expected to increase regenerative medicine. Clinical trials with various cell types derived from iPS cells have been performed since 2014 when a sheet of retinal pigment epithelial cells obtained from iPS cells was transplanted into patients with age-related macular degeneration.

4 Jul 2023

Albino Squid Illuminates Cephalopod Brain Activity

A team of researchers at the Marine Biological Laboratory (MBL) has successfully engineered an albino strain of Euprymna berryi, the hummingbird bobtail squid.

21 Jun 2023

Utilizing Genome Editing to Encourage High Crop Yields

According to a recent study released in the journal Nature on June 14th, 2023, scientists from the University of California, Davis, and an international team of researchers utilized the genome-editing tool CRISPR-Cas to generate disease-resistant rice plants.

16 Jun 2023

Dual CRISPR Gene Drive Systems Target a Specific Gene

According to recent research from North Carolina State University, scientists have created a “homing gene drive system” based on CRISPR/Cas9 that could be used to suppress populations of Drosophila suzukii vinegar flies—so-called “spotted-wing Drosophila” that severely damage soft-skinned fruit in North America, Europe, and parts of South America.

13 Jun 2023

CRISPR/Cas9 Unlocks the Key Gene in the Development of Coral Skeleton Formation

Recent research conducted by Phillip Cleves of Carnegie employs sophisticated CRISPR/Cas9 genome editing technologies to identify a gene essential to stony corals’ capacity to construct complex reef designs. Proceedings of the National Academy of Sciences published this.

6 Jun 2023

Antioxidant Enzymes Relocate to the Nucleus in Response to DNA Damage

In crisis, the nucleus calls antioxidant enzymes to the rescue. The nucleus being metabolically active is a profound paradigm shift with implications for cancer research.

2 Jun 2023