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The Role of Trifunctional Enzymes in Antibiotic Production

Biochemists at the National University of Singapore (NUS) have identified a new subclass of trifunctional enzymes in gram-positive bacteria that play an important role in the manufacture of an antibiotic lanthipeptide.

2 Dec 2024

Comprehensive Review of Intracellular Checkpoints in NK Cell Biology and Cancer

Natural killer (NK) cells play an important role in the innate immune response to cancer and viral infections, and their presence in tumors correlates with improved patient outcomes in a variety of cancers.

29 Nov 2024

The Role of RNA Polymerase and Ribosomes in Gene Expression

DNA within a cell contains the genetic instructions necessary for building proteins.

29 Nov 2024

Developing Plant-Based Strategies to Mitigate DNAN Pollution

The increased use of a chemical compound to replace TNT in explosive devices has a damaging and long lasting effect on plants, new research has shown.

29 Nov 2024

LysoTRAP Strategy Offers Hope for Clearing Viral Infections Across Variants

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences have recently developed a novel lysosomal strategy for clearing viruses and their variants.

28 Nov 2024

Stanford Researchers Develop New Approach to Make Cancer Cells Self-Destruct

Our bodies divest themselves of 60 billion cells every day through a natural process of cell culling and turnover called apoptosis.

28 Nov 2024

Breakthrough in Understanding DNA Gyrase Paves Way for New Antibiotics

Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Centre have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic target.

27 Nov 2024

Unmasking the Molecular Mechanisms of Melanoma

LMU researchers have discovered how the interplay between a key protein and an endolysosomal ion channel promotes tumor development in skin cancer.

24 Nov 2024

How CRISPRi is Helping Combat Drug-Resistant Tuberculosis

Findings on isoniazid-resistant M. tuberculosis reveal key vulnerabilities, suggesting new avenues for treatment strategies against drug-resistant tuberculosis.

20 Nov 2024

Advanced Sequencing Uncovers Cause of Rare Mitochondrial Encephalopathy

Mitochondrial diseases are among the most prevalent hereditary metabolic disorders, known to occur in one out every 5000 births.

19 Nov 2024

New Study Compares MALDI-TOF MS Assays for Detecting Carbapenemase Activity

Austrian researchers evaluate MALDI-TOF MS assays for carbapenemase detection, assessing their reliability and practicality in managing resistant infections.

18 Nov 2024

Study Shows How Genetic Variations Can Enhance Cancer Drug Effectiveness

By exploiting the genetic variation in cancer cells, an already approved cancer drug demonstrated enhanced effects against cancer cells in specific patient groups.

15 Nov 2024

New Bioluminescent Proteins Enable Excitation-Free Imaging in Living Organisms

Bioluminescence is the natural chemical process of light creation in some living creatures that makes fireflies flicker and some jellyfish glow.

14 Nov 2024

Bioengineered Yeast Achieves Breakthrough in Mass-Producing Herbal Medicine

Herbal medicine is difficult to produce on an industrial scale. A team of Kobe University bioengineers manipulated the cellular machinery in a species of yeast so that one such molecule can now be produced in a fermenter at unprecedented concentrations.

14 Nov 2024