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CRISPR Unlocks ‘Sleeping’ Genes—A Potential Cure for Prader-Willi Syndrome?

CRISPR epigenome editing successfully reactivates silenced genes in Prader-Willi Syndrome, highlighting potential for targeted therapies in genetic disorders.

20 Feb 2025

Blocking Cholesterol Metabolite May Prevent Parkinson's Disease Progression

Researchers led by Zhentao Zhang at Wuhan University, China have discovered a cholesterol metabolite that plays a critical role in the development of Parkinson's disease in mice.

19 Feb 2025

Engineered Phages Deliver Therapeutic Proteins to Intestines

Engineered phages transform gut bacteria into drug delivery systems, releasing therapeutic proteins that reduce inflammation and promote satiety in obesity.

19 Feb 2025

Novel Anti-CRISPR Protein Targets Cas13b RNA Nuclease

There are numerous potential uses for the CRISPR-Cas gene scissors, ranging from antiviral treatments and diagnostics to the treatment of genetic disorders.

18 Feb 2025

Gene Editing Breakthrough Creates CoQ10-Producing Rice Varieties

A team of Chinese scientists has used targeted gene editing to develop rice that produces coenzyme CoQ10 (CoQ10), a vital compound for human health.

17 Feb 2025

Groundbreaking Gene Switch Offers New Hope for Metabolic Disease Treatments

ETH researchers have developed a new gene switch that can be activated using a commercially available nitroglycerine patch applied to the skin.

17 Feb 2025

Study Reveals How Dead Bacteria Provide Nutrients to Neighbors

Darwin's theory of natural selection provides an explanation for why organisms develop traits that help them survive and reproduce.

14 Feb 2025

How Bacteriophages Build a Protein-Based Nucleus to Outsmart Bacteria

Jumbo phages utilize a complex protein import system, with Imp1 as a key gatekeeper, to transport proteins into their protective nucleus-like compartment.

14 Feb 2025

Genetic Editing Reveals Key Functions of Bean Plant Genes in Nitrogen Fixation

Beans are a key food at the dietary level, boasting high nutritional value and constituting the most directly consumed legume.

8 Feb 2025

New Synthesis Method Makes Ibogaine More Accessible for Research

Ibogaine, a psychoactive compound derived from plants, has garnered attention for its anti-addictive and anti-depressant properties.

7 Feb 2025

New CRISPR Tool Reveals Key Lymphoma Genes

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in lymphoma development and therapy.

7 Feb 2025

Zika Virus Tricks Mosquitoes by Making Infected Humans Smell More Appealing

Recent research reveals Zika virus modifies host odors, making infected individuals more attractive to mosquitoes, impacting disease transmission dynamics.

5 Feb 2025

Random Versions of Human Genomes Created to Unlock Disease Mechanisms

The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought.

3 Feb 2025

Human Cell Lines Reveal Genome's Tolerance to Structural Variation

The most advanced engineering of human cell lines to date has been accomplished by scientists, demonstrating that genomes are more robust against significant structural changes than previously understood.

31 Jan 2025

New Microfluidic Device can Detect SARS-Cov-2 with Revolutionary Sensitivity

VirusHB-Chip offers groundbreaking sensitivity in detecting SARS-CoV-2 in plasma, saliva, and stool, transforming COVID-19 diagnostics and treatment strategies.

30 Jan 2025

Study Reveals How Male Ruff Birds Use a "Super Enzyme" to Tame Excess Testosterone

We normally associate high testosterone levels with male dominance and aggression. Among ruffs – a shore bird that breeds across Europe and Asia – some males suffer from too much of it.

24 Jan 2025

New Breakthrough Pushes DNA-Nanoparticle Motors Closer to Natural Protein Speed

DNA-nanoparticle motors are exactly as they sound: tiny artificial motors that use the structures of DNA and RNA to propel motion by enzymatic RNA degradation.

23 Jan 2025

New Method Enables 20 Color Bioluminescent Imaging for Live Cells

Imaging live cells with fluorescent proteins has long been a crucial technique for understanding cellular behavior. While bioluminescent proteins offer several advantages over fluorescent proteins, the limited availability of color variants has made it difficult to observe multiple targets simultaneously.

23 Jan 2025

Microglia Response Varies Between Male and Female Mice

A collision happens. Someone is hurt, a head injury, a concussion. Just as the first responders arrive to help the person, inside the brain, another "crew" of responders is busy clearing debris and repairing injured tissue.

22 Jan 2025

New Insights into the Structure and Function of a Key Viral Protein

Researchers at Harvard Medical School and Boston University Chobanian & Avedisian School of Medicine have mapped a crucial part of the Nipah virus, a deadly bat-borne infection that has been responsible for human outbreaks every year since its discovery in 1999.

21 Jan 2025