Neurodegenerative Diseases News and Research

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Inventia Life Science collaborates with MSD to develop 3D advanced cell models for neurodegenerative disease drug discovery

Inventia Life Science, a world leader in advanced cell models for biomedical research and drug discovery, today announced a collaboration with MSD (tradename of Merck & Co., Inc., Rahway, N.J., USA) using Inventia’s RASTRUM™ 3D cell culture platform.

From Inventia Life Science 16 Feb 2023

New approach to better target cellular proteins

By studying how enzymes move from one membrane compartment to another inside a cell, scientists at the University of Illinois Chicago have figured out a way to better target cellular proteins, which play a role in many diseases.

16 Feb 2023

New center at UCLA focuses on the microbiome’s role in disease prevention

Among the most promising areas of scientific inquiry is the study of the human microbiome and its effect on health. To fuel more rapid progress in this field, Andrea and Donald Goodman and Renee and Meyer Luskin have made a $20 million gift to establish the UCLA Goodman–Luskin Microbiome Center.

16 Feb 2023

Novel mechanism of DNA repair occurring in neurons uncovered

"Use it or lose it" goes the adage, applied liberally to everything from our muscles to our minds, especially as we age.

16 Feb 2023

New method triggers and analyzes the dynamics of brain protein linked to Alzheimer’s

Scientists are not yet clear on how the tau protein changes from a benign protein essential for normal function in our brains into the toxic neurofibrillary tangles that are a signature of Alzheimer's and other neurodegenerative diseases.

15 Feb 2023

Versatile molecular toolbox expands the scope of gene regulation

Rice University scientists have enlisted widely used cancer therapy systems to control gene expression in mammalian cells, a feat of synthetic biology that could change how diseases are treated.

15 Feb 2023

Structure of amyloid fibers formed by the protein hnRNPDL-2 determined

Using high-resolution cryo-electron microscopy (cryo-EM), UAB researchers determined the structure of amyloid fibers formed by the protein hnRNPDL-2, which has been linked to limb-girdle muscular dystrophy type 3 and concluded that the protein’s inability to form amyloid ﬁbers, rather than aggregation, would be the cause of the disease.

6 Feb 2023

RNA-G quadruplexes in living cells: A real-time study

Amyotrophic lateral sclerosis (ALS), sometimes referred to as Stephen Hawking’s disease and Lou Gehrig’s disease is a neurological condition that causes the body’s muscles to gradually lose control.

2 Feb 2023

Researchers create a tool to predict the effects of different diets on cancerous and healthy cells

A tool was developed by researchers to forecast the impact of various dietary plans on both cancerous and healthy cells.

30 Jan 2023

Ubiquigent collaborates with University of Glasgow on translational structural biology to accelerate drug discovery within the (de)ubiquitylation field

Ubiquigent Limited (Ubiquigent), a drug discovery and development company harnessing novel deubiquitinase (DUB) modulators as new therapeutics for areas of high unmet medical need, today announced it is supporting a Master’s student at the University of Glasgow (UoG) to undertake a research project on USP30, a DUB implicated in neurodegenerative, renal, and cardiovascular diseases.

From Ubiquigent Limited 23 Jan 2023

Involvement of the piRNA pathway in brain plasticity and successful aging

The Neurobiology of miRNA team, headed by Davide De Pietri Tonelli of the Istituto Italiano di Tecnologia (IIT-Italian Institute of Technology), established a link between a family of small RNA molecules known as piRNAs and brain inflammation.

16 Dec 2022

Tankyrase protein plays an important role in helping drive bowel cancer

The inner workings of the main protein involved in an extensive range of cellular processes have been disclosed by researchers. This possibly sets the stage for improved and less toxic cancer drugs.

25 Nov 2022

Revitalized immune cells improve waste removal from the brain

Damaged protein clusters in the brain are a hallmark of many neurodegenerative diseases, including Parkinson’s, Alzheimer’s, and others. Although they have made significant efforts, scientists have only partially succeeded in finding treatments for these conditions by removing these toxic clusters.

11 Nov 2022

Researchers reveal key developmental difference between the brains of modern humans and Neanderthals

AZoLifesciences speaks to Dr. Anneline Pinson and Prof. Dr. Wieland B. Huttner from The Max Planck Institute of Molecular Cell Biology and Genetics about their latest research which found a greater neuron production in the frontal lobe during brain development in modern humans than Neanderthals, due to the change of a single amino acid in the protein TKTL1.

From The Max Planck Institute 20 Sep 2022

Researchers analyze how clusters of molecules meet inside cells

A developing area studies how clusters of molecules gather inside of cells, similar to how oil droplets form and separate from the water in a vinaigrette.

From New York University (NYU) 15 Sep 2022

Simple blood test helps identify patients developing neurotoxic side effects

The treatment of various tumors has been transformed by cell-based immunotherapy, often known as CAR-T cell therapy. To target and combat specific forms of leukemia and lymphoma, the treatment employs genetically engineered T cells.

8 Sep 2022

Scientists discover latent stem cells that respond to injury in the central nervous system of mice

Scientists at the Francis Crick Institute have identified a group of latent stem cells that respond to injury in the central nervous system of mice. If a similar type of cell exists in humans, they could offer a new therapeutic approach to treat brain and spinal cord injuries.

23 Aug 2022

Scientists determine the contribution of DNA recombinations to genomic diversity in health and disease

Researchers from Japan’s RIKEN Center for Integrative Medical Sciences, working with colleagues from all over the world, found that recombinations of particular genomic sequences, which are reproduced millions of times in the genome of each human cell, are common in both normal and disease states.

28 Jul 2022

Researchers reveal novel mechanism that links interferon activation and α-synuclein function in neurons

There are no disease-modifying therapies for Parkinson’s disease that can alter the course of the disease.

25 Jul 2022

Researchers create novel human cell line to explore blinding eye disorders

Researchers at the LSU Health New Orleans Neuroscience Center of Excellence have created a novel, experimental human cell line from retinal pigment epithelial cells, under the supervision of Boyd Professor Nicolas Bazan, MD, PhD.

14 Jul 2022

Neurodegenerative Diseases News and Research

Inventia Life Science collaborates with MSD to develop 3D advanced cell models for neurodegenerative disease drug discovery

New approach to better target cellular proteins

New center at UCLA focuses on the microbiome’s role in disease prevention

Novel mechanism of DNA repair occurring in neurons uncovered

New method triggers and analyzes the dynamics of brain protein linked to Alzheimer’s

Versatile molecular toolbox expands the scope of gene regulation

Structure of amyloid fibers formed by the protein hnRNPDL-2 determined

RNA-G quadruplexes in living cells: A real-time study

Researchers create a tool to predict the effects of different diets on cancerous and healthy cells

Ubiquigent collaborates with University of Glasgow on translational structural biology to accelerate drug discovery within the (de)ubiquitylation field

Involvement of the piRNA pathway in brain plasticity and successful aging

Tankyrase protein plays an important role in helping drive bowel cancer

Revitalized immune cells improve waste removal from the brain

Researchers reveal key developmental difference between the brains of modern humans and Neanderthals

Researchers analyze how clusters of molecules meet inside cells

Simple blood test helps identify patients developing neurotoxic side effects

Scientists discover latent stem cells that respond to injury in the central nervous system of mice

Scientists determine the contribution of DNA recombinations to genomic diversity in health and disease

Researchers reveal novel mechanism that links interferon activation and α-synuclein function in neurons

Researchers create novel human cell line to explore blinding eye disorders

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