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PNPLA3 Gene Variant Linked to Liver Injury After Chemotherapy in Colorectal Cancer Patients

PNPLA3 Gene Variant Linked to Liver Injury After Chemotherapy in Colorectal Cancer Patients

A new international study led by Mayo Clinic researchers has identified a genetic factor that may explain why some patients with colorectal cancer that has spread to the liver experience more severe liver damage after chemotherapy.

30 Sep 2025

Microbial Molecule Controls Cancer Progression and Boosts Chemotherapy

Microbial Molecule Controls Cancer Progression and Boosts Chemotherapy

An international team of scientists led by researchers from the MRC Laboratory of Medical Sciences (LMS), Imperial College London, and the University of Cologne discovered that microbes associated with tumors produce a molecule that can control cancer progression and improve chemotherapy efficacy.

15 Sep 2025

BioDlink Fast-Tracks Global Growth with Bevacizumab Launch in Colombia and Pakistan

BioDlink Fast-Tracks Global Growth with Bevacizumab Launch in Colombia and Pakistan

BioDlink announced that its self-developed bevacizumab injection biosimilar has received marketing approval from Colombia’s National Institute for Surveillance of Medicines and Foods (INVIMA) and Pakistan’s Drug Regulatory Authority of Pakistan (DRAP).

8 Sep 2025

Microbial Signatures Help Distinguish Colorectal Tumors from Other Cancers

Microbial Signatures Help Distinguish Colorectal Tumors from Other Cancers

Colorectal cancer is unique in having its own microbial 'fingerprint' – according to new research from the University of East Anglia.

4 Sep 2025

Multi-Omics Approaches Reveal New Insights into Colorectal Cancer Liver Metastasis

Multi-Omics Approaches Reveal New Insights into Colorectal Cancer Liver Metastasis

Colorectal cancer is among the most prevalent and lethal malignancies worldwide, with liver metastases occurring in nearly one-third of patients and accounting for a major share of cancer-related deaths.

29 Jul 2025

Small Genetic Change in Humans Weakens Immune Attack on Solid Tumors

Small Genetic Change in Humans Weakens Immune Attack on Solid Tumors

New research from UC Davis Comprehensive Cancer Center has uncovered an evolutionary change that may explain why certain immune cells in humans are less effective at fighting solid tumors compared to non-human primates.

4 Jul 2025

Uncovering the Gut Virome's Role in Health and Disease

Uncovering the Gut Virome's Role in Health and Disease

The human gut is home to trillions of microbes, yet scientific understanding has largely focused on bacteria, leaving the virome—the community of viruses—relatively uncharted.

4 Jul 2025

Chromosome Imbalance Disrupts Mitochondria Through Protein Aggregates

Chromosome Imbalance Disrupts Mitochondria Through Protein Aggregates

It has been known for several years that abnormal chromosome numbers lead to protein imbalances in the affected cells. Researchers at RPTU have now investigated the detailed effects of such imbalances.

30 Jun 2025

Do Genetic Variants That Affect DNA Methylation Influence Colorectal Cancer Risk or Outcomes?

Do Genetic Variants That Affect DNA Methylation Influence Colorectal Cancer Risk or Outcomes?

The study identifies genetic variants influencing colorectal cancer risk through DNA methylation, suggesting new avenues for targeted screening and prevention.

20 Jun 2025

Targeting RNA Polymerase 1 Rewires Cancer Cell Splicing and Halts Growth

Targeting RNA Polymerase 1 Rewires Cancer Cell Splicing and Halts Growth

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences uncovered a new tumor-suppressive response that could lead to novel therapies targeting hard-to-treat cancers.

19 Jun 2025

Gut Microbiome Offers Clues to Detecting and Treating Gastrointestinal Diseases

Gut Microbiome Offers Clues to Detecting and Treating Gastrointestinal Diseases

Scientists have discovered a range of 'biomarkers' that could help to improve detection and treatment of gastrointestinal diseases (GIDs) such as gastric cancer (GC), colorectal cancer (CRC), and inflammatory bowel disease (IBD).

29 May 2025

Machine Learning Reveals Molecular Profile Differences in Colorectal Cancer Patients

Scientists aiming to advance cancer diagnostics have developed a machine learning tool that is able to identify metabolism-related molecular profile differences between patients with colorectal cancer and healthy people.

24 May 2025

How LEM-3 Cleaves DNA Bridges During Cell Division Revealed

How LEM-3 Cleaves DNA Bridges During Cell Division Revealed

If DNA bridges remain between chromosomes after cell division, chromosomes become improperly segregated, resulting in genetic instability and cancer.

20 May 2025

Loss of SOX9 Gene Linked to Aggressive Colorectal Cancer

Loss of SOX9 Gene Linked to Aggressive Colorectal Cancer

Colorectal cancer is the second leading cause of cancer-related death globally. Although some of the molecular changes associated with colorectal cancer are known, how they contribute to cancer development is not yet well defined.

15 May 2025

Potential Therapeutic Target for Aggressive Colorectal Cancers

Potential Therapeutic Target for Aggressive Colorectal Cancers

Colorectal cancer ranks as the second leading cause of cancer-related mortality worldwide.

13 May 2025

New Drug Combo Shows Promise Against Aggressive Leukemia in Landmark Study

New Drug Combo Shows Promise Against Aggressive Leukemia in Landmark Study

A novel drug combination targeting LSD1 and GSK3 shows promise in treating acute myeloid leukemia by promoting cell differentiation and reducing tumor growth.

28 Apr 2025

Lab-Grown Lung Cancer Cells to Unlock Targeted Treatments

Lab-Grown Lung Cancer Cells to Unlock Targeted Treatments

Scientists at the Cancer Research Manchester Institute have created a new model of Lung Squamous Cell Carcinoma (LUSC), a common type of lung cancer, to study the development, activity, and vulnerabilities of the disease.

9 Apr 2025

Study Reveals How H3K36 Methylation Controls Intestinal Cell Plasticity and Regeneration

Study Reveals How H3K36 Methylation Controls Intestinal Cell Plasticity and Regeneration

Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer.

26 Mar 2025

New Database Provides Insights into snoRNA Expression in Zebrafish

New Database Provides Insights into snoRNA Expression in Zebrafish

Small nucleolar RNAs (snoRNAs) are non-coding RNA molecules whose role in gene regulation and their association with certain diseases, such as inflammatory bowel disease (IBD) or colorectal cancer, has only recently become known.

20 Mar 2025

New Discovery in RNA Splicing Could Transform Treatment of Aggressive Cancers

New Discovery in RNA Splicing Could Transform Treatment of Aggressive Cancers

Alternative RNA splicing is like a movie editor cutting and rearranging scenes from the same footage to create different versions of a film.

17 Mar 2025

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