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Neuroscientists Identify Brain Cells Acting as the "Disappointment Meter"

University of Oregon neuroscientists have identified a group of brain cells that essentially act as a "disappointment meter," announcing when reality is falling short of expectations.

3 Jun 2026

Bispecific Antibodies Target Tumors While Sparing Healthy Tissue

A new generation of bispecific antibodies effectively targets cancer cells, minimizing toxicity and enhancing treatment precision in preclinical studies.

3 Jun 2026

Atomic Snapshots of Human SMUG1 Unveil the Secrets of DNA Repair

Researchers have captured the first atomic structures of human SMUG1, an enzyme that helps cells repair damaged DNA.

3 Jun 2026

Zebrafish Provide New Insights Into Microbiome Dynamics

A new advance in animal husbandry involving a popular aquarium fish should speed the pace of discovery in laboratory studies of host-microbe interactions, researchers report.

2 Jun 2026

Cell Phase Separation Creates Droplets That Optimize and Activate Kinase Signaling

Within the past decade, biologists have discovered that one strategy cells use to keep their contents organized is a phenomenon known as phase separation.

2 Jun 2026

Novel Cyclic Peptides Cross Cell Membranes to Fight Disease

Many diseases are driven by proteins interacting with each other inside cells. But blocking these interactions with drugs is difficult because our typic "small-molecule" drugs often prove to be too small to grip the broad, flat surfaces involved in protein-protein interactions.

1 Jun 2026

Redesigning Antibiotics to Overcome Bacterial Efflux Pump Resistance

A new way of designing antibiotics could support the discovery of new treatments for drug-resistant infections.

1 Jun 2026

Nanoparticles Boost Delivery of Lung Cancer Drugs 30-Fold

Lung cancer remains one of the world’s deadliest cancers, yet despite decades of effort to develop new drugs, many fail because they don’t stay in the body long enough to be effective or because they damage healthy organs.

1 Jun 2026

Scientists Discover a Metabolic Switch That Regulates Ferroptosis

The loss of an enzyme can reprogram cellular metabolism in a way that protects cells from a specific form of cell death. Paradoxically, the presumed blockade of this enzyme has the opposite effect.

1 Jun 2026

Researchers Identify Neural Pathway Governing Memory Organization

When a person has a new experience, their brain faces a subtle but critical decision: should this experience be categorized with other stored memories, or should it be filed away as its own new memory? Getting it right allows the brain to help people navigate the world.

28 May 2026

Scientists Reveal How Surface Acids Prevent Bacteria From Blobbing

Researchers have discovered how acids on the surface of bacteria give these microscopic organisms their characteristic "rod" shape-by keeping an enzyme at bay that would otherwise turn the cylindrical cells into shape-shifting blobs.

27 May 2026

Extracellular Acidosis Disrupts Internal Transport Systems of Living Cells

A new scientific study led by the Universidad Carlos III de Madrid (UC3M) describes the mechano-chemical mechanism by which the acidity of the cellular environment destabilizes microtubules, the "avenues" that organize internal cellular traffic.

27 May 2026

Ovarian Cancer Fluid Helps Tumors Evade Cell Death

Ascites in ovarian cancer rewires tumor metabolism, protecting cells from ferroptosis and promoting metastasis, revealing potential therapeutic targets.

27 May 2026

Dividing Cells Replicate Chromosomal Errors to Trigger Advanced Tumor Progression and Growth

Megan Sweet slices tumors.

26 May 2026

Advanced Framework Improves Gene Set Enrichment Analysis to Uncover Hidden Multi-Omics Data Insights

Scientists at the Icahn School of Medicine at Mount Sinai have created a new artificial intelligence (AI) model that helps reveal how genes function together inside human cells, offering a powerful new way to understand biology and disease.

25 May 2026

Study Connects Lysosomal Lipid Movement Directly to Cellular Growth Signaling

While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for the metabolite. Some tumor cells use as much cholesterol as they can access to accelerate their growth beyond the capabilities of normal cells.

25 May 2026

Specialized Intative Cells Release Peptide Hormones to Rapidly Signal an Amino Acid Deficiency

Eating is not only about getting enough calories. Animals also need to choose the right nutrients. When the body lacks protein, it must seek essential amino acids - the protein building blocks that cannot be made internally and must come from food.

23 May 2026

AI Designs Custom Miniproteins to Precisely Control Cell Receptors

G protein-coupled receptors, or GPCRs, sit in the plasma membrane, the boundary that defines the inside and outside of a living cell. They communicate with nearly every physiological process in our bodies - from the ability to see and smell, to sensing of adrenaline, insulin, nutrients and medicines.

22 May 2026

Scientists Capture Live-Action Footage of Housekeeping Immune Cells Engulfing Melanoma

Scientists at the Garvan Institute of Medical Research have captured, for the first time, 'housekeeping' immune cells actively attacking and engulfing live melanoma cells – a discovery that could change the way we approach treatment for one of Australia's most common and deadly cancers.

22 May 2026

High Protein Levels Bypass Functional BRCA Defenses to Generate Toxic Double-Strand Genomic Breaks

When it comes to cancer, tumor suppressor genes are usually thought of as the "good guys." These genes make proteins that protect and repair DNA in cells.

22 May 2026