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AI Designs Custom Miniproteins to Precisely Control Cell Receptors

G protein-coupled receptors, or GPCRs, sit in the plasma membrane, the boundary that defines the inside and outside of a living cell. They communicate with nearly every physiological process in our bodies - from the ability to see and smell, to sensing of adrenaline, insulin, nutrients and medicines.

22 May 2026

Scientists Capture Live-Action Footage of Housekeeping Immune Cells Engulfing Melanoma

Scientists at the Garvan Institute of Medical Research have captured, for the first time, 'housekeeping' immune cells actively attacking and engulfing live melanoma cells – a discovery that could change the way we approach treatment for one of Australia's most common and deadly cancers.

22 May 2026

High Protein Levels Bypass Functional BRCA Defenses to Generate Toxic Double-Strand Genomic Breaks

When it comes to cancer, tumor suppressor genes are usually thought of as the "good guys." These genes make proteins that protect and repair DNA in cells.

22 May 2026

Dental Pulp Stem Cell Subsets Triggers Rapid Cellular Senescence and Tooth Decay

With age, teeth get increasingly brittle and susceptible to damage from tooth decay, which can eventually lead to tooth loss. Teeth have an intrinsic capability to regenerate, a process which is driven by dental pulp stem cells (DPSCs) which replenish the dental pulp including the dentin-producing cells called odontoblasts.

22 May 2026

Drug-Resistant Superbugs Contribute to Nearly Five Million Global Human Deaths Every Year

A team of researchers from Florida State University and the National High Magnetic Field Laboratory is looking to nature to find microbes that can be used to create new antibiotics to treat the growing threat of drug-resistant bacteria.

22 May 2026

High-Resolution Cryo-EM Imaging Reveals a Hidden Secondary Drug Binding Site on Bacterial Ribosomes

A new Nature Communications study, published May 19, redefines scientists' understanding of how a popular class of antibiotics work.

22 May 2026

Scientists Find Key Genetic Boundary That Dictates Immune System Failure

Not all broken genes fail in the same way: some simply stop working, while others interfere with what still works.

22 May 2026

Polymer Platforms Help Focus Immune Attack on Cancerous Tumors

Conventional immune checkpoint inhibitors, such as anti-PD-1/PD-L1 and anti-CTLA-4 antibodies, can reinvigorate T cells but typically benefit less than 30% of patients.

21 May 2026

Scientists Synthesize Rare Sea Sponge Molecules to Boost Future Cancer Drug Development

Florida State University chemists have synthesized new molecules derived from bacteria found in a Pacific Ocean sea sponge, a breakthrough for the future of drug development, particularly for rare forms of cancer.

21 May 2026

Open-Chip Design Separates Fluid Resistance From Wall Confinement to Trace Cell Behavior

Most cancer studies focus on chemical signals or stiff tumor surroundings, but the stickiness of the fluid itself has received little attention. For glioblastoma, the invasion front is about eight times more viscous than the necrotic core, creating a rising resistance that migrating cells must overcome.

21 May 2026

Sensory Nerve Signals Block the Immune System's Response to Lung Cancer

Researchers at the Francis Crick Institute have revealed that sensory nerve signals interfere with the immune system's response to lung cancer. This previously unrecognized neuroimmune connection could be targeted to improve responses to immunotherapy.

20 May 2026

Novel Synthetic Molecules Attack Cell Membranes to Prevent Severe Bacterial Infections

In a new study, researchers show how so‑called TriPcides can target the bacterium Staphylococcus aureus, including antibiotic‑resistant strains such as MRSA. The compounds disrupt the bacteria's ability to cause infection and can also kill dormant bacterial cells, which are often difficult to treat with existing antibiotics.

20 May 2026

Researchers Reverse Immune Cell Dysfunction by Degrading Key Gene Regulatory Proteins

Researchers at the Icahn School of Medicine at Mount Sinai, Bristol Myers Squibb, and the University of Oxford have discovered a way to give worn-out immune cells a second wind in the fight against multiple myeloma.

20 May 2026

New 3D Cortical Tissue Models Incorporate Microglia to Bridge Preclinical Translation Gaps

28bio today announced CNS-3D Inflammatory Organoids, designed to evaluate efficacy of anti-inflammatory drugs by quantifying their ability to reduce inflammatory injury, preserve tissue health, and restore neuronal network activity.

20 May 2026

New 3D Human Liver Model Mimics Chronic Disease For 30 Days

Researchers developed a 3D liver model that functions for a month, replicating inflammation and fibrosis, crucial for studying liver diseases and therapies.

19 May 2026

Dual-Action Protein Found to Fuel and Repair Cancer

According to a recent study, a protein best known for fueling cancer development also aids in the survival of damaged tumor cells by repairing their DNA, which might impact how certain cancers are treated.

18 May 2026

Supercomputer Simulations Map Sodium Pumping in Pathogenic Bacteria

The Na+-NQR enzyme is vital for energy production in pathogenic bacteria like the one that causes cholera, making it a highly promising target for new antibiotics.

15 May 2026

Novel RNA Analysis Method Supports Antiviral Drug Discovery

Researchers from A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a new method, called 'sm-PORE-cupine', to study individual RNA molecules and reveal how their structures influence gene regulation, a fundamental process that affects how cells function in health and disease.

15 May 2026

Restricted Interaction Peptides Change Shape to Lock Therapy Inside Solid Tumors

Medications are designed to treat diseased tissues while sparing healthy ones, often by attaching the drug to something that helps guide it directly to its target.

14 May 2026

HIV Mutations Undermine Broadly Neutralizing Antibody Treatments Across Strains

Broadly neutralizing antibodies (bNAbs) are among the most promising new treatments for HIV, offering the potential to forego traditional daily dose of antiretroviral drugs.

12 May 2026

Drugs News and Research

AI Designs Custom Miniproteins to Precisely Control Cell Receptors

Scientists Capture Live-Action Footage of Housekeeping Immune Cells Engulfing Melanoma

High Protein Levels Bypass Functional BRCA Defenses to Generate Toxic Double-Strand Genomic Breaks

Dental Pulp Stem Cell Subsets Triggers Rapid Cellular Senescence and Tooth Decay

Drug-Resistant Superbugs Contribute to Nearly Five Million Global Human Deaths Every Year

High-Resolution Cryo-EM Imaging Reveals a Hidden Secondary Drug Binding Site on Bacterial Ribosomes

Scientists Find Key Genetic Boundary That Dictates Immune System Failure

Polymer Platforms Help Focus Immune Attack on Cancerous Tumors

Scientists Synthesize Rare Sea Sponge Molecules to Boost Future Cancer Drug Development

Open-Chip Design Separates Fluid Resistance From Wall Confinement to Trace Cell Behavior

Sensory Nerve Signals Block the Immune System's Response to Lung Cancer

Novel Synthetic Molecules Attack Cell Membranes to Prevent Severe Bacterial Infections

Researchers Reverse Immune Cell Dysfunction by Degrading Key Gene Regulatory Proteins

New 3D Cortical Tissue Models Incorporate Microglia to Bridge Preclinical Translation Gaps

New 3D Human Liver Model Mimics Chronic Disease For 30 Days

Dual-Action Protein Found to Fuel and Repair Cancer

Supercomputer Simulations Map Sodium Pumping in Pathogenic Bacteria

Novel RNA Analysis Method Supports Antiviral Drug Discovery

Restricted Interaction Peptides Change Shape to Lock Therapy Inside Solid Tumors

HIV Mutations Undermine Broadly Neutralizing Antibody Treatments Across Strains

The Future of Vision Restoration With ReVision Implant

How a Single List Is Changing Visibility for Women in Science

How Avatar Medical's 3D Technology Is Transforming How We Visualize the Human Body

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