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Engineered Base Editor Corrects ACTA2 Mutation in Rare Childhood Disease

Multisystemic smooth muscle dysfunction syndrome (MSMDS) is a rare condition associated with stroke, aortic dissection (tearing) and death in childhood.

13 Sep 2025

Metastatic Lung Cancer Cells Cozy Up to Neurons and Form Synapses

Small cell lung cancer cells that metastasize to the brain cozy up to neurons and form working electrical connections, called synapses, according to an upcoming study led by Stanford Medicine researchers.

11 Sep 2025

Stress Reshapes Brain Cells and Alters Activity in Mice

Canadian researchers show that stress modifies the morphology of brain cells in mice, directly influencing the rodents' level of physical activity.

5 Sep 2025

Tackling KRAS Mutations Unlocks New Hope for Pancreatic Cancer Patients

Accounting for nearly 90% of all pancreatic cancers, pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of just 13%. Late-stage diagnosis, limited surgical options, and toxic chemotherapy regimens contribute to its poor outcomes.

2 Sep 2025

New Computational Tool Enhances Cancer Tissue Analysis for Personalized Treatment

Scientists at the Icahn School of Medicine at Mount Sinai have developed a powerful new computational tool that could transform how cancer tissues are analyzed and help pave the way for more personalized treatments.

27 Aug 2025

Genetic Signatures of Neural Progenitor Cells Uncovered in the Adult Brain

For much of the 20th century it was thought that the adult brain was incapable of regeneration. This view has since shifted dramatically and neurogenesis – the birth of new neurons – is now a widely accepted phenomenon in the adult brain, offering promising avenues for treating many neurological conditions.

22 Aug 2025

Single-Cell Map Reveals Epigenomic Regulation of Human Fat Tissue

A new study has created the first single-cell map of how DNA is regulated and organized inside different cell-types of human fat tissue.

21 Aug 2025

How Primary Cilia Shape the Fate of Fat Precursor Cells

Too much fat can be unhealthy: how fat cells, so-called adipocytes, develop, is crucial for the function of the fat tissue.

21 Aug 2025

Missing Microexons Disrupt Synapse-Related Proteins in Pediatric Glioma

A new study, led by researchers at Children's Hospital of Philadelphia (CHOP), identified tiny pieces of messenger RNA that are missing in pediatric high-grade glioma tumors but not in normal brain tissues.

19 Aug 2025

Amino Acids as Key Mediators in the Tumor Immune Dialogue

The tumor microenvironment is not just a site of cancer growth—it is a high-stakes metabolic contest where tumor and immune cells vie for limited resources.

19 Aug 2025

New Method Enables Human Cells to Initiate Meiosis Outside the Body

More than one-sixth of adults around the world experience infertility in their lifetime. There is a high unmet need not only for increased access to affordable, high-quality fertility care for those in need but, importantly, also for new biomedical solutions that can address the root causes of infertility.

18 Aug 2025

New Gene Silencers Offer Hope for Hereditary Blood Disorders

According to a recent study, chemical tags that were previously thought of as genetic clutter are really potent gene silencers; eliminating them could lead to safer treatments for hereditary blood disorders.

18 Aug 2025

Sugarcoated RNA Helps the Body Avoid Autoimmune Reactions

To our immune system, naked RNA is a sign of a viral or bacterial invasion and must be attacked. But our own cells also have RNA.

7 Aug 2025

Magnetic Microneedle Robots Transform Tissue Slicing and Cultivation

In a pioneering development for the biomedical field, a research team led by Yuanjin Zhao from Nanjing Drum Tower Hospital, China, has published a research article in Engineering.

6 Aug 2025

New Computational Tool Reveals How Long Non-Coding RNAs Control Gene Expression

Long non-coding RNAs (lncRNA) are a type of RNA molecule that do not carry instructions to make proteins. Instead, they influence how other genes are expressed.

6 Aug 2025

Scientists Uncover New Activation Mechanism of the Human Sweet Taste Receptor

Sweet taste receptors are proteins in taste buds that detect sugar and other sweeteners, but the mechanism underlying how they elicit a sweet response has been unclear.

5 Aug 2025

Hemostatic Dressing Developed for Severe Burn Injuries

A team led by Dr. Chao Zhong and Bolin An of the Chinese Academy of Sciences' Shenzhen Institute of Advanced Technology, along with Dr. Yan Liu of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, created a novel hemostatic dressing based on bacterial cellulose (BC) that allows for quick and long-lasting bleeding control.

4 Aug 2025