Hospital News and Research

RSS

AI-Powered Protein Engineering for Precise and Scalable Gene Therapy

Genome editing has progressed rapidly, showing promising outcomes for the treatment of genetic disorders, yet there remains potential for enhancement.

23 Apr 2025

Study Reveals Shared Genetic Basis for Autism Spectrum Disorder and DM1

Researchers from the University of Las Vegas Nevada (UNLV) and The Hospital for Sick Children (SickKids) have discovered a genetic connection between autism spectrum disorder (ASD) and myotonic dystrophy type 1 (DM1), a rare genetic disorder.

23 Apr 2025

DNA Organization Offers Clues for Advancing Stem Cell Therapy

Scientists at the University of California, Riverside, have discovered how adult stem cells retain their regenerative power. The researchers demonstrate in a paper published in the journal Genes & Development that these cells rely on a group of helper proteins called histone chaperones — organizers or guides known to help package our two-meter-long genome when cells need to divide or switch on specific genes.

22 Apr 2025

New Blood Test Could Revolutionize Alzheimer’s Diagnosis

Research confirms the Lumipulse serum p-tau217 assay's effectiveness in diagnosing Alzheimer's, paving the way for accessible blood-based testing in healthcare.

18 Apr 2025

Researchers Develop STITCHR to Insert Whole Genes Without Unwanted Mutations

Investigators from Mass General Brigham and Beth Israel Deaconess Medical Center have developed STITCHR, a new gene editing tool that can insert therapeutic genes into specific locations without causing unwanted mutations.

12 Apr 2025

Genetic Sequencing Leads to Major Discovery in Neurodevelopmental Disorders

A seminal study from researchers at the Icahn School of Medicine at Mount Sinai and their collaborators in the United Kingdom, Belgium, Spain, the Netherlands, and Iceland has uncovered a new genetic cause of neurodevelopmental disorders (NDDs).

11 Apr 2025

Breakthrough Delivery System Advances CRISPR-Based Treatments

A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater efficiency than before.

10 Apr 2025

Rapid Growth of Blood Cancer Driven by a Single Genetic ‘HIT’

A new study has unveiled when chronic myeloid leukaemia, a type of cancer that affects the blood and bone marrow, arises in life and how fast it grows.

10 Apr 2025

New Protein Identified as Regulator of Mitochondrial Calcium Transport

Calcium transport into and out of mitochondria – the powerhouses of cells – is central to cellular energy production and cell death.

9 Apr 2025

Scientists Capture Dynamic Process of Chromatin Remodeling in Action

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases.

7 Apr 2025

New Discovery Reveals How Cells Repair Damaged Mitochondrial DNA

Damage to the genetic material of mitochondria – the mitochondrial DNA or mtDNA for short – can lead to diseases such as Parkinson's, Alzheimer's, amyotrophic lateral sclerosis (ALS), cardiovascular diseases and type 2 diabetes.

7 Apr 2025

USC Engineers Develop EchoBack CAR T-Cells for Cancer Treatment

Imagine a super-charged immune cell that can launch a focused attack on stubborn solid tumors - a smart fighter that destroys cancer cells for days without tiring.

3 Apr 2025

New Genetic Targets for Atherosclerosis Prevention

Genetic variations that raise the risk of atherosclerosis have been found by Swedish researchers.

1 Apr 2025

How Drug-Resistant Bacteria Use Antimicrobial Tools to Outcompete Others

A drug-resistant type of bacteria that has adapted to health care settings evolved in the past several years to weaponize an antimicrobial genetic tool, eliminating its cousins and replacing them as the dominate strain.

24 Mar 2025

Research Unveils Mechanism Behind Evolution of Organelles from Bacteria

Organelles in cells were originally often independent cells, which were incorporated by host cells and lost their independence in the course of evolution.

20 Mar 2025

Spotiphy Revolutionizes Spatial Transcriptomics with AI for Single-Cell Resolution

Spatial transcriptomics is a cutting-edge technique that characterizes gene expression within sections of tissue, such as heart, skin or liver tissue.

14 Mar 2025

Generative AI Enhances Spatial Gene Expression Analysis in Tissue Samples

Spatial transcriptomics is an advanced technique that analyzes gene expression within tissue sections, such as those from the heart, skin, or liver. These analyses offer valuable insights into how spatial organization influences cellular functions across various biological contexts and diseases.

13 Mar 2025

‘Rescue’ Mutations Protect Liver From Damage in Patients With Genetic Disorder

Acquired DNA mutations found in the SERPINA1 gene can protect liver cells from damage in patients with alpha-1 antitrypsin deficiency, new research shows.

11 Mar 2025

Rare ITSN1 Gene Variants Found to Significantly Elevate Parkinson's Risk

A new study published in Cell Reports reveals a breakthrough discovery linking genetic variants in the gene ITSN1 to a significantly elevated risk of Parkinson's disease, a neurodegenerative condition that affects nearly 2% of adults older than 65 years.

10 Mar 2025