Immune Response News and Research

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IL-12 Adjuvant Shows Promise in Boosting T-Cell Immunity

Scientists are always searching for new weapons to add to their arsenal in the pursuit of creating vaccinations that would better support the body’s immune system in fending off disease.

9 Jun 2025

How Heterogeneous Antibody Immunity Shapes Strain Evolution

A new study found that person-to-person heterogeneity in antibody immunity influences which influenza (flu) strains dominate in a population.

4 Jun 2025

Study Reveals Key Proteins Behind CAR-T Cell Therapy Effectiveness

A study conducted by researchers at the Center for Cell-Based Therapy (CTC) highlights key proteins and signaling pathways involved in the efficacy of immunotherapy based on CAR-T cells (lymphocytes modified in the laboratory to fight cancer).

4 Jun 2025

Evolution of Cancer Genomes During Metastasis

Research on cancer metastasis uncovers genetic complexities, showing that copy-number alterations play a key role in tumor evolution and treatment resistance.

3 Jun 2025

Study Reveals How APOE Isoforms Impact Brain Microglia

A study reveals how APOE isoforms influence microglial activity in Alzheimer's, highlighting the need for targeted interventions based on genetic risk factors.

28 May 2025

Reversible DNA Modification Controls Replication and Gene Activity

Study uncovers ADP-ribosylation's role in Mycobacterium tuberculosis, showing how DNA modification controls replication and gene expression for survival.

23 May 2025

New Discovery Explains Increased Infection Risk in Patients with Mitochondrial Diseases

Patients with rare mitochondrial diseases already face a host of serious health issues, from muscle weakness to neurological problems and heart conditions.

21 May 2025

Novel Bacterial Immune Weapon that Starves Viral Invaders

The discovery of Cat1 reveals how CARF effectors use complex structures to inhibit viral replication, advancing our understanding of bacterial immune responses.

19 May 2025

Protein Balance Offers Key to Overcoming Immunotherapy Resistance

Immunotherapy uses a person's own immune system to fight cancer. Immune checkpoint inhibitors are one class of immunotherapy that block specific proteins from slowing the immune response.

15 May 2025

Variance Analysis Enhances Genetic Risk Prediction for Blood Cell Traits

A Nature Communications study shows that incorporating variance polygenic scores (vPGS) and variance QTLs (vQTLs) improves genetic risk prediction for blood-related diseases, offering new insight into phenotype variability and lifestyle factors like alcohol intake.

15 May 2025

New Mechanism for Selective Host-Microbe Communication in the Gut

The study reveals how APOL9 selectively binds to gut bacteria, enhancing immune responses and maintaining intestinal health through microbial communication.

15 May 2025

Viral circRNAs Sponge Up Host miRNAs to Weaken Immune Response

In a significant breakthrough, researchers from Florida Atlantic University’s Charles E. Schmidt College of Medicine have uncovered a previously unknown mechanism that allows the human immunodeficiency type 1 virus (HIV-1) to evade the body’s natural defenses, thereby facilitating its survival and replication.

14 May 2025

CAR-T Cell Therapy Causes “Brain Fog,” Independent of Other Cancer Treatments

After treatment with CAR-T cells - immune cells engineered to attack cancer - patients sometimes tell their doctors they feel like they have "brain fog," or forgetfulness and difficulty concentrating.

13 May 2025

Unraveling How E. histolytica Kills Cells and Evades the Immune System

Understanding how E. histolytica attacks human cells and evades immunity is crucial for developing effective treatments and vaccines against this parasite.

13 May 2025

Lipid-Rich Ascites Weakens Immunity in Advanced Ovarian Cancer

Recent research conducted by scientists in Ireland has revealed the significant role of lipid-rich fluid in the abdomen, referred to as ascites, in diminishing the body’s immune response in advanced ovarian cancer.

12 May 2025

Scientists Use AI to Predict Future Viruses and Design Better Vaccines

Effective vaccines dramatically changed the course of the COVID-19 pandemic, preventing illness, reducing disease severity, and saving millions of lives.

10 May 2025

Likarda Paper Highlights Hydrogel Encapsulation with CSS Can Overcome Major Obstacle of Liver Cell Therapies

Likarda, a leading biotech company specializing in the development of enabling technologies for the delivery of both cell therapies and large molecule biologics, announced a new peer-reviewed publication that demonstrates a promising improvement in the effort to develop liver cell-based therapies for patients with chronic liver disease.

23 Apr 2025

Tolerogenic Dendritic Cells in Gut Prevent Allergic Reactions to Food

The immune system must be able to rapidly target invaders such as viruses while avoiding innocuous stimuli, or allergies may develop.

15 Apr 2025

Novel Microscopy Reveals Two-Stage T-Cell Activation During Viral Infection

The research teams led by Wolfgang Kastenmüller and Georg Gasteiger utilized advanced microscopy techniques to investigate the activation and proliferation of specific immune cells, known as T-cells, during viral infections.

11 Apr 2025

Breakthrough Delivery System Advances CRISPR-Based Treatments

A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater efficiency than before.

10 Apr 2025