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Johns Hopkins Team Identifies Distinct Subtypes of Senescent Skin Cells

Johns Hopkins Team Identifies Distinct Subtypes of Senescent Skin Cells

Senescent skin cells, often referred to as zombie cells because they have outlived their usefulness without ever quite dying, have existed in the human body as a seeming paradox, causing inflammation and promoting diseases while also helping the immune system to heal wounds.

29 Apr 2025

Transitioning Pancreatic Cells Retain Cancer Linked Epigenetic Marks

Transitioning Pancreatic Cells Retain Cancer Linked Epigenetic Marks

Johns Hopkins Medicine scientists say they have found a pattern of so-called epigenetic "marks" in a transition state between normal and pancreatic cancer cells in mice, and that the normal cells may keep at least a temporary "memory" of those cancer-linked marks.

25 Apr 2025

Tolerogenic Dendritic Cells in Gut Prevent Allergic Reactions to Food

Tolerogenic Dendritic Cells in Gut Prevent Allergic Reactions to Food

The immune system must be able to rapidly target invaders such as viruses while avoiding innocuous stimuli, or allergies may develop.

15 Apr 2025

Novel Compound Targets Salmonella's Infection Mechanism

Novel Compound Targets Salmonella's Infection Mechanism

Pathogenic Salmonella strains inject effector proteins into gastrointestinal tract cells, allowing them to infiltrate and grow. Bacteria are often consumed with contaminated food.

15 Apr 2025

Study Reveals How Stiffened Osteocytes Contribute to Bone Loss in Aging

Study Reveals How Stiffened Osteocytes Contribute to Bone Loss in Aging

It's no coincidence that our bodies feel a little creakier as we age. The trillions of cells that make up our skeleton age too, and some change in ways that weaken the very structure of our bones.

7 Apr 2025

Scientists Discover Epigenetic Marks in Pancreatic Cancer Transition

Scientists Discover Epigenetic Marks in Pancreatic Cancer Transition

Johns Hopkins Medicine scientists say they have found a pattern of so-called epigenetic "marks" in a transition state between normal and pancreatic cancer cells in mice, and that the normal cells may keep at least a temporary "memory" of those cancer-linked marks.

7 Apr 2025

Enhanced Oral Vaccination with Competitive Gut Bacteria

Enhanced Oral Vaccination with Competitive Gut Bacteria

Researchers are combining vaccination with targeted colonization of the intestine by innocuous microorganisms to combat bacterial infections. This strategy might signal a sea change in the antibiotic crisis.

4 Apr 2025

CD11c Microglia Play Key Role in Neurodevelopmental Delays from Maternal Inflammation

CD11c Microglia Play Key Role in Neurodevelopmental Delays from Maternal Inflammation

A research group led by Nagoya University Graduate School of Medicine in Japan has uncovered a potential mechanism linking maternal inflammation to delayed neurodevelopment in infants.

2 Apr 2025

New Discovery Sheds Light on C. Diff's Survival Mechanism in the Gut

New Discovery Sheds Light on C. Diff's Survival Mechanism in the Gut

The pathogen C. diff - the most common cause of health care-associated infectious diarrhea - can use a compound that kills the human gut's resident microbes to survive and grow, giving it a competitive advantage in the infected gut.

26 Mar 2025

Unlocking CBD’s Potential with Phospholipid Tech

Unlocking CBD’s Potential with Phospholipid Tech

Research shows phospholipid complexation enhances CBD's solubility and absorption, paving the way for more effective treatments for epilepsy and chronic pain.

26 Mar 2025

Can Tissue Engineering and Regenerative Medicine Reverse Spinal Cord Injuries?

Can Tissue Engineering and Regenerative Medicine Reverse Spinal Cord Injuries?

Advances in tissue engineering offer hope for spinal cord injury repair, utilizing biomaterials, stem cells, and bioactive molecules to promote regeneration.

20 Mar 2025

Mechanical Forces Determine the Winners in Cell Competition

Mechanical Forces Determine the Winners in Cell Competition

Trial of strength at the cellular level: cells are in constant competition with each other and so eliminate diseased or unwanted cells.

18 Mar 2025

Mitochondria Found to Control DNA Repair Protein and Delay Inflammaging

Mitochondria Found to Control DNA Repair Protein and Delay Inflammaging

In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and enables the healing of the many bumps, bruises and scrapes along the way.

14 Mar 2025

Study Reveals How DNA Reorganization Helps Cells Survive UV Damage

Study Reveals How DNA Reorganization Helps Cells Survive UV Damage

Ultraviolet (UV) radiation from the sun is a well-known cause of DNA damage, which can lead to diseases like skin cancer.

13 Mar 2025

Study Explores the Physiological Role of Nwd1 Gene in MASH Pathogenesis

Study Explores the Physiological Role of Nwd1 Gene in MASH Pathogenesis

Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that progresses without symptoms and is associated with significant global public health concerns.

12 Mar 2025

Microbiome-Based Approach Shows Promise for Treating Ulcerative Colitis

Microbiome-Based Approach Shows Promise for Treating Ulcerative Colitis

The human gut is home to trillions of bacteria that play vital roles in digestion, immunity, and overall health.

12 Mar 2025

Protective ‘Slime’ In The Brain May Help Prevent Aging And Neurodegeneration

Protective ‘Slime’ In The Brain May Help Prevent Aging And Neurodegeneration

The study shows that boosting mucin-type O-glycosylation in aged mice reinforces the blood-brain barrier and improves memory, paving the way for new treatments.

10 Mar 2025

New Method Creates Stable Fatty Acid Solutions for Biological Research

New Method Creates Stable Fatty Acid Solutions for Biological Research

FAs are important in cellular processes such as membrane structure, energy storage, and signaling. However, challenges remain in preparing stable FA solutions due to their amphipathic nature and low solubility in water.

6 Mar 2025

Macrophages Use Bacterial Debris To Fine-Tune Immune Responses

Macrophages Use Bacterial Debris To Fine-Tune Immune Responses

Findings reveal macrophages' role in immune modulation through bacterial metabolites, paving the way for improved therapies for infections and inflammation.

6 Mar 2025

Synthetic Microbiome Treatment Prevents C. difficile Infection in Mice

Synthetic Microbiome Treatment Prevents C. difficile Infection in Mice

A synthetic microbiome therapy, tested in mice, protects against severe symptoms of a gut infection that is notoriously difficult-to-treat and potentially life threatening in humans, according to a team of researchers at Penn State.

4 Mar 2025

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