Melanoma News and Research

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Melanoma is a form of cancer that begins in melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but can also begin in other pigmented tissues, such as in the eye or in the intestines.

Discovery of Dendritic Cell Reprogramming Opens Path to Tailored Cancer Treatments

An international team led by researchers at Lund University in Sweden has identified the molecular tools needed to reprogram ordinary cells into specialized immune cells.

2 Sep 2025

UCLA Researchers Reprogram Stem Cells to Produce Continuous Cancer-Fighting T Cells

In a first-of-its-kind clinical trial, UCLA scientists have shown it's possible to reprogram a patient's blood-forming stem cells to generate a continuous supply of functional T cells, the immune system's most powerful cancer-killing agents.

5 Aug 2025

PD-1 Guides T Cells to Become Long-Term Immune Defenders in the Skin

Weill Cornell Medicine researchers have discovered that PD-1—a molecule best known for putting the brakes on immune cells—also plays a critical role in helping T cells become long-term immune defenders in the skin.

30 Jul 2025

AI-Designed Proteins Offer New Hope for Personalized Cancer Immunotherapy

Precision cancer treatment on a larger scale is moving closer after researchers have developed an AI platform that can tailor protein components and arm the patient's immune cells to fight cancer.

29 Jul 2025

mRNA Vaccine Supercharges Immunotherapy Against Cancer

An experimental mRNA vaccine improved the tumor-fighting benefits of immunotherapy in a mouse model study, bringing researchers one step closer to their aim of generating a universal vaccination to “wake up” the immune system against cancer.

21 Jul 2025

Molecular Chatter Between Cells Drives Tumor Growth and Immune Suppression

A Ludwig Cancer Research study has identified a complex chain of molecular chatter by which cancer cells, exploiting ordinary metabolic processes, program one set of noncancerous cells to manipulate another set of such cells to support their growth and survival.

18 Jul 2025

Regulators of Cancer Cell Communication During Invasion

This study identifies key genes regulating neural crest functions in melanoma, revealing insights into collective migration and potential therapeutic targets.

16 Jul 2025

Exercise Boosts Immune Response in Cancer Through Bacterial Metabolites

A new study from the University of Pittsburgh shows for the first time how exercise improves cancer outcomes and enhances response to immunotherapy in mice by reshaping the gut microbiome.

10 Jul 2025

Targeting RNA Polymerase 1 Rewires Cancer Cell Splicing and Halts Growth

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences uncovered a new tumor-suppressive response that could lead to novel therapies targeting hard-to-treat cancers.

19 Jun 2025

IL-12 Adjuvant Shows Promise in Boosting T-Cell Immunity

Scientists are always searching for new weapons to add to their arsenal in the pursuit of creating vaccinations that would better support the body’s immune system in fending off disease.

9 Jun 2025

Herpes Virus Protein Enhances T-Cell Survival for Cancer Therapy

Recent studies reveal the herpes virus may enhance cancer treatment by activating T cell pathways, improving immunotherapy effectiveness against tumors.

29 May 2025

CRISPR Unlocks ‘Sleeping’ Genes—A Potential Cure for Prader-Willi Syndrome?

CRISPR epigenome editing successfully reactivates silenced genes in Prader-Willi Syndrome, highlighting potential for targeted therapies in genetic disorders.

20 Feb 2025

Genetically Engineered Mice May Accelerate Anti-Aging Research

Washington State University scientists have created genetically-engineered mice that could help accelerate anti-aging research.

5 Feb 2025

New Method Helps T Cells Live Longer and Fight Cancer More Effectively

Researchers from the University of Pittsburgh have developed a new way to grow T cells in the lab that enables them to live longer and better destroy cancer cells in a mouse model of melanoma compared to those grown in traditional growth media.

29 Jan 2025

Digoxin Weakens Cancer’s Spread by Targeting Cell Clusters

Some tumor types spread throughout the body and develop metastases instead of staying at their original location.

27 Jan 2025

AI Model 'MUSK' Advances Cancer Diagnosis with Multimodal Data Integration

MUSK, a vision-language model, enhances cancer diagnosis by integrating multimodal data, outperforming existing methods in prognosis and treatment predictions.

23 Jan 2025

Genetic Mutation in the Inherited DNA Found to Drive Breast Cancer Metastasis

Ninety percent of cancer deaths are due to the spread of cancer, not complications from the original tumor.

10 Dec 2024

Brazilian Study Offers Fresh Perspectives on Pancreatic Cancer Genetics

Pancreatic cancer has recently been included in the list of diseases about which Brazil's National Cancer Institute (INCA) periodically publishes statistics.

9 Dec 2024

Unmasking the Molecular Mechanisms of Melanoma

LMU researchers have discovered how the interplay between a key protein and an endolysosomal ion channel promotes tumor development in skin cancer.

24 Nov 2024

Discovery of Large Tandem Duplications Opens New Avenues for Cancer Treatment

Cancer researchers at the University of Chicago and the University of California, San Francisco (UCSF) have discovered that mutations in certain genes can lead to the accumulation of DNA errors, resulting in a specific type of genetic change known as large tandem duplications (TDs) that can arise from the collision of two critical cellular processes: transcription and DNA replication.

21 Nov 2024