Metabolites News and Research

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Cryo-EM Structures Reveal How IVD Mutations Cause Isovaleric Acidemia

IVD is a key enzyme in leucine catabolism, catalyzing the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA.

10 Jun 2025

Newly Identified Molecules from Blood Bacterium Show Promise in Combating Skin Aging

Indole metabolites from the blood bacterium P. sanguinis demonstrate potential in anti-aging skin treatments by lowering inflammation and oxidative damage.

6 Jun 2025

Gut Microbiome Offers Clues to Detecting and Treating Gastrointestinal Diseases

Scientists have discovered a range of 'biomarkers' that could help to improve detection and treatment of gastrointestinal diseases (GIDs) such as gastric cancer (GC), colorectal cancer (CRC), and inflammatory bowel disease (IBD).

29 May 2025

How Microbiome Changes Contribute to Cardiovascular Aging

UZH researchers uncover how gut bacteria affect cardiovascular health, revealing phenylacetic acid's role in blood vessel aging and heart disease development.

29 May 2025

Peptide Metabolites: A New Frontier in Antiviral Therapies

Interest in antiviral treatments has grown significantly since the COVID-19 pandemic. Effective peptide treatments made from natural substances are in high demand right now due to the increased attention being paid to peptide-based drugs like Wegovy.

27 May 2025

Machine Learning Reveals Molecular Profile Differences in Colorectal Cancer Patients

Scientists aiming to advance cancer diagnostics have developed a machine learning tool that is able to identify metabolism-related molecular profile differences between patients with colorectal cancer and healthy people.

24 May 2025

Natural Deep Eutectic Solvents Enhance Yield and Antibacterial Activity of Zanthoxylum bungeanum

NADES treatments significantly boost essential oil yield and antibacterial activity in Zanthoxylum bungeanum, offering a natural solution to food contamination.

23 May 2025

Novel Bacterial Immune Weapon that Starves Viral Invaders

The discovery of Cat1 reveals how CARF effectors use complex structures to inhibit viral replication, advancing our understanding of bacterial immune responses.

19 May 2025

Solgate Streamlines SLC Drug Discovery with INTEGRA’s Automated Pipetting Systems

Solgate – a biotech start-up based in Klosterneuburg, Austria – is accelerating the development of new therapies targeting solute carrier (SLC) transporters using automated liquid handling systems from INTEGRA Biosciences.

14 May 2025

Depleting TM6SF2 in the Gut Worsens Liver Fat Buildup, Study Finds

A new study finds that gut-specific TM6SF2 depletion exacerbates liver fat accumulation and dysbiosis in mice on high-fat diets, highlighting its importance in gut-liver metabolic regulation.

12 May 2025

AI Brings Brain Metabolism to Life in 3D with MetaVision3D

The MetaVision3D tool transforms 2D tissue sections into 3D brain metabolome models, offering critical insights into metabolism and neurological diseases.

31 Mar 2025

Hidden Causal Interaction Network Found in Cervical Cancer Cells

A Japanese research team has discovered a novel global cooperative phenomena of cell interactions in cervical cancer cells. Their findings suggest that the cells are metabolically connected in a functional network.

26 Mar 2025

Researchers Create Yeast Consortium for Efficient Lignan Biosynthesis

Lignans are low molecular weight polyphenolic compounds with important antitumor and antiviral properties.

25 Mar 2025

Research Unveils Mechanism Behind Evolution of Organelles from Bacteria

Organelles in cells were originally often independent cells, which were incorporated by host cells and lost their independence in the course of evolution.

20 Mar 2025

Researchers Create 'Colocatome' to Study Tumor Cell Interactions

Even cells experience peer pressure. Scientists have long studied the ins and outs of cancer cells to learn more about the disease, but they're increasingly finding that noncancerous cells near the cancer cells exert a powerful influence over a tumor's trajectory.

13 Mar 2025

Macrophages Use Bacterial Debris To Fine-Tune Immune Responses

Findings reveal macrophages' role in immune modulation through bacterial metabolites, paving the way for improved therapies for infections and inflammation.

6 Mar 2025

Gut Microbes Transform Excreted Glucose into Crucial Fatty Acids

Gut microbes that were thought to feed exclusively on dietary fiber also get fed sugar from our guts, from which they produce short-chain fatty acids that are crucial to many body functions.

4 Mar 2025

Lactylation Levels Influence Cardiac Development and Regeneration in Mice

This study is led by Dr. Xiaodong Luan (Institute of Clinical Medicine, Peking Union Medical College Hospital), Dr. Shuyang Zhang (Department of Rare Diseases, Peking Union Medical College Hospital) and Dr. He Huang (Shanghai Institute of Materia Medica, Chinese Academy of Sciences).

3 Mar 2025

New Study Uncovers Evolutionary Link in B6 Metabolism

An investigation conducted by a group of scientists at the University of Kentucky’s Martin-Gatton College of Agriculture, Food and Environment has uncovered an unexpected biochemical link between the immune responses of plants and the neurological health of humans.

18 Feb 2025

Researchers Identify Key Mechanism in Transformation of Stem Cells to Cancer Cells

Nearly 60,000 people are diagnosed with oral cancer in the U.S. every year, according to the American Cancer Society, and the rate of new cases continues to rise.

5 Feb 2025