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Scientists Uncover Inner Workings of Biomolecular Condensates Linked to ALS

Inside the cell reside many tiny assembly factories and warehouses that gather together all of the proteins and RNAs-which carry out instructions from our DNA-that a living being needs.

27 Nov 2025

Scientists Map How Transcription Factors Interpret DNA Sequences

With a new study in the journal Cell, researchers at Stanford University and Stockholm University have contributed to increased knowledge about gene regulation in human cells.

27 Nov 2025

Discovery Reveals Unexpected Role for OTULIN in Controlling Tau Expression

Scientists have uncovered a surprising mechanism by which a brain enzyme called OTULIN controls the expression of tau, the protein that forms toxic tangles in Alzheimer's disease.

26 Nov 2025

Ribosome Collisions Activate Key Stress Signaling Mechanisms in Cells

LMU researchers uncover the mechanism by which ribosomes raise alarms in the cell.

25 Nov 2025

Targeting Rhoa to Restore Function in Hematopoietic Stem Cells

Aging is defined as the deterioration of function overtime, and it is one of the main risk factors for numerous chronic diseases.

25 Nov 2025

Discovery Offers a Potential Way to Boost Tissue Resident Memory T Cell Numbers

We owe a lot to tissue resident memory T cells (TRM). These specialized immune cells are among the body's first responders to disease.

24 Nov 2025

Novel Active Substance Drives Cancer Cells Toward Self Destruction

A new active substance attacks a key protein in tumor cells, leading to complete degradation. In cell experiments, this caused cancer cells to lose their protection and die.

20 Nov 2025

Global Constraint Principle Offers Fresh Insight into Life’s Growth Limits

A research team including a scientist of Earth-Life Science Institute (ELSI) at Institute of Science Tokyo, Japan, has identified a novel principle in biology that mathematically explains why the growth of organisms slows as nutrients become more abundant-a phenomenon known as "the law of diminishing returns."

12 Nov 2025

Inter-Organelle Crosstalk Regulates Protein Biogenesis in Eukaryotic Cells

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions between organelles are important for regulating cellular processes.

11 Nov 2025

St. Jude Scientists Discover Hidden Binding Pocket in Nuclear Receptors

A study from St. Jude Children's Research Hospital uncovered an alternative binding pocket within nuclear receptors, revealing a much-needed new therapy route for this important class of drug targets.

7 Nov 2025

Scientists Reveal Nonenzymatic Role of NUDT5 in Purine Pathway Regulation

Inside every cell, a finely tuned metabolic network determines when to build, recycle, or stop producing essential molecules.

7 Nov 2025

Molecular Dynamics Simulations Accurately Recreate the RNA Folding Process

Ribonucleic acid (RNA) is one of life's most versatile molecules, with roles going far beyond being a messenger of genetic code, as it is fundamentally involved in gene regulation, processing, and maintenance across all living systems.

5 Nov 2025

Scientists Uncover How "P Bodies" Guide Stem Cells to Their Destinies

How do stem cells know what to become? Nearly three decades after scientists isolated the first human embryonic stem cells, researchers are still working hard to understand precisely how a single, undifferentiated cell can become any one of the roughly 200 cell types that make up the human body.

4 Nov 2025

Weill Cornell Scientists Develop Safe and Precise Tool to Control Gene Activity

Investigators at Weill Cornell Medicine have developed a versatile and non-toxic technology for controlling the activity of any gene in a cell. Such "gene-switch" tools allow scientists to "turn on" or "turn off" a target gene to study how it works, model diseases and design new therapies.

4 Nov 2025

Frazzled Protein Found to Shape Fast Neural Connections in Fruit Flies

Florida Atlantic University neuroscientists have uncovered a surprising role for a protein named "Frazzled" (known as DCC in mammals) in the nervous system of fruit flies, showing how it helps neurons connect and communicate with lightning speed.

3 Nov 2025

Protein Dysfunction Could be the Cause of Diseases Resulting From Shortened Telomeres

New research from the University of Wisconsin–Madison reveals that dysfunction in a protein essential to maintaining stability in our chromosomes may be responsible for serious - and sometimes deadly - diseases.

31 Oct 2025

Breakthrough Small Molecule Offers New Hope for Diabetes Treatment

Researchers from the University at Albany and NYU Grossman School of Medicine have found a way to block a key cellular pathway known to drive chronic inflammation and impaired wound healing in people with diabetes.

31 Oct 2025

Aptamer Technology Offers Breakthrough in Identifying Zombie Cells

When it comes to treating disease, one promising avenue is addressing the presence of senescent cells.

28 Oct 2025

Study Reveals How TR4 Fungus Silences Banana Defense Genes

Bananas rank among the world's most valuable staple crops, yet their production faces severe losses from Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (Foc) tropical race 4 (TR4).

24 Oct 2025

Breakthrough Cryo-EM Study Maps Herpes Replication Protein in New Detail

An international research team has successfully identified the initial high-resolution structures of the herpes simplex virus origin-binding protein (OBP), which is an essential element in viral DNA replication that has remained structurally uncharacterized for the past forty years.

24 Oct 2025