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Light-Based Technique Reveals How Extracellular Vesicles Interact With Cells

The tiny bubbles that carry signals between cells throughout the body were discovered decades ago, but precisely what they contain and how their cargo affects recipient cells is still largely a mystery.

12 Dec 2025

New Insights Into LARP6-RNA Binding Could Lead to Fibrosis Therapies

A research team at the Institute of Molecular Biophysics and the Department of Chemistry and Biochemistry at Florida State University has made a significant discovery regarding the interaction between a protein present in the human body and RNA, which may pave the way for innovative treatments for tissue scarring, commonly referred to as fibrosis.

12 Dec 2025

Scientists Discover First Human DNA-Cutting Enzyme That Responds to Tension

An international research team at the University of Hong Kong has discovered a human protein known as ANKLE1, which is recognized as the first DNA-cutting enzyme (nuclease) in mammals that can detect and respond to physical tension in DNA.

10 Dec 2025

How Tumor Stem Cells Hijack Neutrophils to Evade Immunotherapy

Immunotherapy has revolutionized cancer care by training the immune system to detect and destroy tumors.

9 Dec 2025

Circular Single-Stranded DNA Molecule Can Simultaneously Silence Multiple MicroRNAs

Professor Dongsheng Liu of Tsinghua University, Professor Ziyang Hao of Capital Medical University, and Researcher Yuanchen Dong of the Institute of Chemistry, Chinese Academy of Sciences, have collaborated to develop a circular single-stranded DNA molecule capable of simultaneously silencing multiple miRNAs.

4 Dec 2025

Single-Cell RNA Imaging Uncovers Four Distinct Neuron Bands in the Hippocampus

Researchers at the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC have identified a previously unknown pattern of organization in one of the brain's most important areas for learning and memory.

4 Dec 2025

Study Exposes Ancestry Biases in Current Gene Annotations

Human gene maps contain major blind spots because they were built largely from the DNA sequences of people with European ancestry, according to a study published today in Nature Communications.

4 Dec 2025

Engineered Gut Bacteria With MiRNA Nanoparticles To Reverse IBD

Biomimetic nanoparticles delivering microRNA to gut bacteria enhance protective metabolites, repair intestinal barriers, and alleviate colitis symptoms.

3 Dec 2025

New Insight Into Light-Guided Growth of Bristleworm Eyes

A new study, led by the University of Vienna and the Alfred Wegener Institute in Bremerhaven, shows how the eyes of adult marine bristleworms continue to grow throughout life – driven by a ring of neural stem cells reminiscent of vertebrate eyes.

2 Dec 2025

Capturing a Self-Splicing Ribozyme in Motion

RNA is a central biological macromolecule, now widely harnessed in medicine and nanotechnology. Like proteins, RNA function often depends on its precise three-dimensional structure.

28 Nov 2025

Real-Time Visualization Reveals the Transcriptional Gearbox

Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing RNA in eukaryotic cells and eventually giving rise to proteins.

28 Nov 2025

Scientists Uncover Inner Workings of Biomolecular Condensates Linked to ALS

Inside the cell reside many tiny assembly factories and warehouses that gather together all of the proteins and RNAs-which carry out instructions from our DNA-that a living being needs.

27 Nov 2025

Scientists Map How Transcription Factors Interpret DNA Sequences

With a new study in the journal Cell, researchers at Stanford University and Stockholm University have contributed to increased knowledge about gene regulation in human cells.

27 Nov 2025

Discovery Reveals Unexpected Role for OTULIN in Controlling Tau Expression

Scientists have uncovered a surprising mechanism by which a brain enzyme called OTULIN controls the expression of tau, the protein that forms toxic tangles in Alzheimer's disease.

26 Nov 2025

Ribosome Collisions Activate Key Stress Signaling Mechanisms in Cells

LMU researchers uncover the mechanism by which ribosomes raise alarms in the cell.

25 Nov 2025

Targeting Rhoa to Restore Function in Hematopoietic Stem Cells

Aging is defined as the deterioration of function overtime, and it is one of the main risk factors for numerous chronic diseases.

25 Nov 2025

Discovery Offers a Potential Way to Boost Tissue Resident Memory T Cell Numbers

We owe a lot to tissue resident memory T cells (TRM). These specialized immune cells are among the body's first responders to disease.

24 Nov 2025

Novel Active Substance Drives Cancer Cells Toward Self Destruction

A new active substance attacks a key protein in tumor cells, leading to complete degradation. In cell experiments, this caused cancer cells to lose their protection and die.

20 Nov 2025

Global Constraint Principle Offers Fresh Insight into Life’s Growth Limits

A research team including a scientist of Earth-Life Science Institute (ELSI) at Institute of Science Tokyo, Japan, has identified a novel principle in biology that mathematically explains why the growth of organisms slows as nutrients become more abundant-a phenomenon known as "the law of diminishing returns."

12 Nov 2025

Inter-Organelle Crosstalk Regulates Protein Biogenesis in Eukaryotic Cells

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions between organelles are important for regulating cellular processes.

11 Nov 2025