Neurodegeneration News and Research

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Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons.

Analysis Reveals Blurred Neural Patterns During Failed Cognitive Switches

Most people have experienced the feeling: switching from one task to another, only to find the brain momentarily stuck in the old mode of thinking. Sometimes, even after realizing a strategy no longer works, the mind keeps returning to it anyway.

21 May 2026

Researchers Compare Embryonic and Adult Mouse Brain Targets to Map Memory Networks

A peer-reviewed invited review published today in Genomic Psychiatry argues that the adult brain, when it learns and remembers and rewires, is not inventing something new.

20 May 2026

New 3D Cortical Tissue Models Incorporate Microglia to Bridge Preclinical Translation Gaps

28bio today announced CNS-3D Inflammatory Organoids, designed to evaluate efficacy of anti-inflammatory drugs by quantifying their ability to reduce inflammatory injury, preserve tissue health, and restore neuronal network activity.

20 May 2026

Advanced Genomic Techniques Map Cellular Changes During Brain Aging

While much is mysterious about the aging process, change over time remains its cornerstone. The biological shifts that accompany aging seemingly occur in many cells in the body.

18 May 2026

AI Reveals Dynamic DNA Accessibility Within Nucleosome Structures

Every cell in the human body squeezes over six feet of DNA into a miniscule speck invisible to the naked eye-like compressing a whole house into a single sugar cube.

30 Apr 2026

Study Reveals the "Black Box" of Protein Quality Control in the ER

Over the past few years, Kivanç Birsoy of Rockefeller University and his colleagues in the Laboratory of Metabolic Regulation and Genetics have uncovered amazing information about the antioxidant glutathione, which has numerous vital functions in the body, including eliminating free radicals and repairing cellular damage.

20 Apr 2026

Scientists Uncover How "Sorting Hubs" Clear Damaged Proteins From Cells

Inside every cell, a cleanup operation runs around the clock. Proteins are constantly damaged by wear and tear. Some can be repaired, while others must be dismantled and recycled. When this system fails, damaged proteins accumulate in clumps associated with diseases such as Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia.

16 Apr 2026

New Technology Tracks Real-Time Gene Activity to Find Common Disease Targets

Diseases like cancer or neurodegeneration are known to arise from genetic misfires. But treating such complex conditions hasn't been simply a matter of identifying the malfunctioning genes involved. With hundreds of genetic mutations spanning diverse pathways at play, connecting the dots between a constellation of mutations and a specific outcome has proved to be enormously difficult.

16 Apr 2026

"Zombie" Macrophages Accumulate in Aging Tissues and Diseased Livers

UCLA researchers have identified a rogue population of immune cells that quietly accumulates in aging tissues and in the livers of people with fatty liver disease. Clearing these cells, they found, dramatically reduced inflammation and reversed liver damage in mice - even while the animals remained on an unhealthy diet.

16 Apr 2026

Janelia Scientists Develop New Method To Study Blood-Brain Barrier Proteins

Think it was hard to get into Studio 54? Try getting through the blood-brain barrier.

10 Apr 2026

Novel ENDOtollins Block Harmful Inflammation While Preserving Infection Response

Scripps Research scientists have developed a new class of drug compounds that reduce harmful inflammation while leaving the body's ability to fight infections intact-a long-sought goal in treating autoimmune diseases.

7 Apr 2026

New PanNDA Atlas Maps Protein Networks in Neurodegenerative Diseases

Neurodegenerative diseases form a tangled biological web with overlapping molecular signatures and symptoms. To decode this complexity, a multi-institute collaboration led by St. Jude Children's Research Hospital scientists developed the pan-neurodegeneration atlas (PanNDA).

24 Mar 2026

Comprehensive Brain Atlas Maps Epigenetic Changes During Aging

Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer's to Parkinson's to ALS and beyond, is expected to double every 20 years.

13 Mar 2026

ANKIB1 Identified as the Essential Master Switch for Innate Immunity

Innate immune sensors – known as pattern recognition receptors (PRRs) – detect specific molecular components of bacterial or viral intruders.

9 Mar 2026

Specialized Tanycyte Brain Cells Found to Play Key Role in Tau Clearance

Accumulation of the protein tau in the brain is one of the hallmarks of Alzheimer's disease. In a paper publishing March 5 in the Cell Press journal Cell Press Blue, researchers report a previously unknown mechanism that appears to enable the build-up of tau.

6 Mar 2026