Neurodegenerative Diseases News and Research

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Ultra-High-Resolution 3D Microscopy Captures Distinct Presynaptic Protein Organization States

A new study led by researchers at the University of Wisconsin School of Medicine and Public Health examines how different versions of the same protein can alter neuronal communication.

25 Sep 2026

Cambridge Researchers Look Inside Living Antarctic Cells for First Time

Engineers have built the first microscope to see inside living cells in sub-zero conditions, revealing secrets of Antarctic fish survival.

23 Sep 2026

Researchers Identify Peptide That Counters Key Processes of Neurodegenerative Disorders

Alzheimer's disease and related neurodegenerative disorders are among medicine's most challenging conditions, progressively impairing memory, movement and independence. Now, researchers at the University of California San Diego School of Medicine have identified a naturally occurring peptide - a small protein fragment called catestatin (CST) - that may help counter several key processes driving neurodegeneration.

23 Sep 2026

Novel Base-Editing Approach Shows Promise for Inherited Motor Neuron Disorders

A team of researchers led by Professor Haruhisa Inoue (Center for iPS Cell Research and Application, Kyoto University) and Professor Yuishin Izumi (Tokushima University) demonstrated that adenine base editing can correct a disease-causing genetic mutation and alleviate neurodegeneration in hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P), providing proof of concept for a precision gene therapy for inherited motor neuron diseases.

21 Sep 2026

AI-Designed Protein Vehicle Enables Lower RNA Dosing While Maximizing Therapeutic Protein Expression

Researchers at Helmholtz Munich and TUM have developed Synthetic Transfer Vehicles (STVs), an entirely new class of RNA transporters. To do so, they combined naturally occurring protein building blocks with synthetic protein structures designed using generative AI.

3 Sep 2026

New Platform Links Dysfunctional Biomolecular Condensates to Microcephaly and Neurodevelopment

When you add drops of oil to water, the oil and water remain separate. Within cells, biological molecules cluster together in a similar way, separating themselves from the rest of the cell. And while they don't have a membrane, they are their own distinct compartments.

3 Sep 2026

Bulky Molecular CRISPR Systems Barely Fit Inside Single Viral Vectors

The ability to precisely adjust the expression of genes inside the human body - ramping up protective ones and tamping down harmful ones - holds enormous potential for treating and preventing disease.

31 Aug 2026

Researchers Struggle Tracking Human Dementia Progress Using Traditional Laboratory Mice

Brain diseases, including dementia, have long been studied using experimental animals such as mice. However, differences between the human and animal genomes have raised concerns that some disease mechanisms may not be fully explained by conventional animal models.

31 Aug 2026

Primate-Specific DNA Change Reveals a New Link to Dementia-Related Neurodegeneration

29 Aug 2026

Reengineering Glial Cell Signaling Pathways to Slow Down ALS Symptoms

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that, according to the CDC, currently impacts around 35,000 Americans-with 5,000 more diagnosed each year.

21 Aug 2026

Breakthrough Discovery Pinpoints How Brain Immune Cells Respond to Toxic Cellular Waste

Researchers at the University of California, San Diego, and their colleagues have discovered a critical cellular mechanism that causes brain degeneration in both a rare childhood condition and the far more prevalent Alzheimer’s disease.

17 Aug 2026

Cells Deploy Specialized Quality Control Factors When Protein Synthesis Fails

Scientists at the Center for Molecular Medicine Cologne (CMMC) and the CECAD Cluster of Excellence on Aging Research have demonstrated in a biomedical study that ribosomes, the protein factories of our cells, face an unusually tough challenge when building large, membrane‑embedded proteins.

13 Aug 2026

New Roadmap Fixes Cellular Waste Accumulation to Halt Brain Degeneration

Researchers at University of California San Diego and their colleagues have identified a key cellular pathway that drives brain degeneration in both a rare childhood disorder and the far more common Alzheimer's disease.

13 Aug 2026

Researchers Engineer AI Framework to Solve Longstanding Protein Isoform Mystery

A single human gene can produce multiple protein isoforms through alternative splicing, greatly expanding the functional diversity of the proteome.

11 Aug 2026

New Single-Cell Database Reveals Hidden Inner Workings of Spinal Cord Circuits

Scientists at St. Jude Children's Research Hospital created a single-cell atlas of a key class of spinal neurons involved in motor coordination. From that resource, they identified a small subgroup of interneurons associated with the speed of rhythmic movements such as walking. The findings, which have implications for understanding spinal cord function and recovery from injury, were published today in Nature Communications.

11 Aug 2026

Research Reevaluates Crucial Microtubule Stabilizing Protein in Dementia Progression

A protein named tau, which has been highly implicated in the world's No. 1 cause of dementia - Alzheimer's disease - and several other neurodegenerative disorders, may spur these diseases in a way that differs greatly from the pathological pathway usually ascribed to it.

7 Aug 2026

Study Offers New Perspective on How Phase Separation Contributes to Gene Regulation

A research team from AIST, the Institute of Science Tokyo, and Ritsumeikan University has demonstrated that the phase behavior of histone–DNA condensates depends on the site of histone acetylation.

6 Aug 2026

New Molecular Discoveries Explain How Protein Mutations Regulate Neurological Illnesses

Researchers at Yale School of Medicine have conducted the first comprehensive structural analyses of a class of proteins whose dysfunction is associated with neurodegenerative diseases.

3 Aug 2026

University of Oklahoma Study Uncovers Internal Recycling System in Photoreceptors

For decades, scientists believed that photoreceptors in the retina relied primarily on neighboring support cells, known as the retinal pigment epithelium (RPE), to remove waste. While the RPE is still responsible for clearing away the worn-out tips of photoreceptors each day, new findings from the University of Oklahoma reveal that photoreceptors also perform much of their own internal housekeeping.

30 Jul 2026

Elevated Levels of Acid Ceramidase Make Zombie Cells Susceptible to Ferroptosis

Our population is aging. The United Nations reports that by 2050, the number of people over the age of 85 on our planet is set to triple.

24 Jul 2026