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Optimizing Laser Pulse Energy for Deep-Brain Imaging Without Tissue Damage

As light travels deeper into the brain, it scatters. Three-photon microscopy, the current state of the art, reduces the resulting background fluorescence and can, in principle, image much deeper than earlier techniques-but to do that, it uses average laser power limits that cause overheating and damage living tissue.

29 Oct 2026

Squeezing Cell Nuclei Loosens DNA to Boost CRISPR Reprogramming Efficiency

Our cells hold about two meters of DNA, folded and compacted to fit inside a nucleus far narrower than a strand of human hair.

24 Oct 2026

Genetic Clue to Autism's Fourfold Difference In Boys and Girls

Findings on MECP2 regulatory variants suggest genetic factors contribute to autism's male bias, enhancing understanding of the disorder's heritability.

22 Oct 2026

Live Organelle Imaging Catches Early Neuronal Stress Before Cell Death

Scientists studying amyotrophic lateral sclerosis (ALS), Parkinson's, Alzheimer's and other neurological diseases are getting unprecedented views inside brain cells, using powerful new microscopes to uncover changes that may begin long before neurons die.

20 Oct 2026

Targeted Interneuron Manipulation Improves Learning and Memory Processing Capabilities

Researchers were able to restore the function of neurons linked to cognitive function and information processing in mice that mimic key features of Alzheimer's disease, showing early promise for the development of a similar targeted therapy in humans.

16 Oct 2026

New Open-Source Resource Maps Adolescent Brain Development Across Large Datasets

Researchers have created a large, openly available neuroimaging resource from more than 24,000 MRI scans of over 10,000 adolescents, providing an unprecedented view of how the brain's wiring develops during adolescence.

15 Oct 2026

Targeting Neural Chloride Homeostasis Mitigates Motor Deficits in Dystrophic Mice

DMD is a severe X-linked disorder caused by dystrophin deficiency and is characterized by progressive muscle degeneration and weakness.

14 Oct 2026

The Story Behind the Butterfly’s Enhanced Visual World of Color

Many insects see the world through hundreds of tiny lenses that are grouped together in a visual organ known as the compound eye. Behind each lens sits a cluster of eight light-detecting cells arranged in a pattern that scientists believe has existed for hundreds of millions of years.

10 Oct 2026

Stem Cell Models Demonstrate Precise Cellular Nibbling of Pathological Fibrils

Researchers at the University of Oxford have uncovered a previously unrecognized protective role for microglia, the brain's resident immune cells, in Parkinson's disease.

8 Oct 2026

Knocking Out Specific Receptor Genes Prevents Dopaminergic Neuronal Cell Death

The protein alpha-synuclein is abundant in healthy brains and plays an important role in enabling communication between nerve cells.

6 Oct 2026

Innovative OpenFISH Technique Enables Integrated Spatial Molecular Imaging in Tissues

Spatial transcriptomics (ST) shows which genes are being expressed and where within a tissue. Spatial metabolomics (SM), on the other hand, maps the location of metabolites—small molecules produced or used by cells—within tissue.

30 Sep 2026

Study Establishes Immune Cell Trafficking as Viable Alzheimer's Target

There is no treatment available today to stop the death of brain cells in neurodegenerative diseases known as tauopathies, including Alzheimer's disease, in which twisted clumps of a protein called tau accumulate in the brain.

29 Sep 2026

Scientists Pinpoint the Brain Circuit That Regulates Metabolism

As the body’s temperature decreases, it compensates by utilizing additional energy to produce heat and stimulating the desire to eat to replenish the energy expended for warmth.

28 Sep 2026

Individual Neurons Display Trial-to-Trial Firing Rate Variability Under Identical Visual Stimulation

Our brains internally represent the outside world through the coordinated activity of billions of neurons.

25 Sep 2026

How Feedback Mechanisms Control Neural Chaos for Stable Visual Processing

What we see appears stable, even though neuronal activity is full of irregular fluctuations. A team led by Dr Mehdi Borjkhani from ICTER has shown, using a minimal model of the primary visual cortex, that two natural feedback mechanisms can constrain chaos and reduce variability in neural activity by up to 93 percent.

23 Sep 2026

KAIST Researchers Develop NUDGE to Steer Cell States Without Permanent Alteration

Which genes need to be controlled to guide a stem cell toward a desired cell type, or to modulate an immune cell's inflammatory response? A Korean research team has developed a general-purpose computational framework that identifies the key targets needed to steer a cell toward a desired state with a single temporary intervention, without permanently altering its genes.

23 Sep 2026

What Drives Pregnancy Cravings? Researchers Find a Clue in the Brain

What causes intense food cravings during pregnancy? Scientists at LSU’s Pennington Biomedical Research Center, working alongside collaborators, have pinpointed a neural mechanism that may explain how pregnancy influences the desire to pursue certain highly appealing foods.

22 Sep 2026

Breakthrough Study Explains Developmental Origins of the Human Brain

For centuries, scientists have thought of the brain as a single, unified organ. But new research led by Stanford Medicine reveals that what we call the brain is two distinct organs that evolved independently over hundreds of millions of years.

21 Sep 2026

Novel Base-Editing Approach Shows Promise for Inherited Motor Neuron Disorders

A team of researchers led by Professor Haruhisa Inoue (Center for iPS Cell Research and Application, Kyoto University) and Professor Yuishin Izumi (Tokushima University) demonstrated that adenine base editing can correct a disease-causing genetic mutation and alleviate neurodegeneration in hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P), providing proof of concept for a precision gene therapy for inherited motor neuron diseases.

21 Sep 2026