Pharmacology News and Research

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Pharmacology is the study of how chemical substances interact with living systems. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties, interactions, toxicology, therapy, and medical applications and antipathogenic capabilities.

New Analytical Framework Captures Coordinated Host and Microbial Disease Responses

The trillions of microorganisms living in our intestine influence our health, from digestion and metabolism to immunity.

5 Aug 2026

Advanced Cellular Mapping Preserves Spatial Architecture During Holistic Herb Interventions

Traditional Chinese medicine is widely recognized for its holistic and systematic mode of action, often described as "multi-component, multi-target, and multi-pathway" regulation.

17 Jul 2026

Breakthrough Imaging Method Maps Whole Cell Signals

Cells are crowded, dynamic places where thousands of molecules interact in tight quarters. Until now, scientists lacked a reliable way to see many of these molecular interactions as they happen.

15 Jul 2026

Atomic Level Discovery Reveals Exactly How Inhaled Anesthetics Silence Neurons

Researchers at Weill Cornell Medicine and Birkbeck, University of London, have identified a site where a commonly used anesthetic binds to sodium ion channels, revealing a molecular mechanism that may explain how these drugs dampen communication between neurons.

10 Jul 2026

New Aptamer Selection Strategy Streamlines Development of Safer Therapeutic Candidates

G protein-coupled receptors (GPCRs) are the most abundantly expressed proteins in the human body, which regulate diverse physiological processes ranging from pain perception to hormone signaling.

8 Jul 2026

Two Antibiotics Outperform Single Drugs Against P. aeruginosa

Findings indicate that combining meropenem with ceftolozane-tazobactam significantly improves treatment outcomes against resistant Pseudomonas aeruginosa.

8 Jul 2026

Southern Medical University Uncovers Crucial Protein Linked to Lung Fibrosis

A study published recently in Current Molecular Pharmacology has uncovered a key mechanism linking aging to persistent pulmonary fibrosis, identifying the transcriptional regulator fPRDM16 as a potential therapeutic target.

26 Jun 2026

Immune Pathway Breakthrough Reveals Critical Sex Differences in Female Glioblastoma

Researchers have identified a critical biological difference in how glioblastoma develops in male and female laboratory models, pinpointing an immune pathway that fuels tumor growth only in females.

24 Jun 2026

New Chromosome Packaging Discovery Explains Unlimited Growth in Cancer Cells

Published today in Nature, researchers at the University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center report a previously unrecognized change in how the cell's genetic material is packaged into structures called chromosomes.

4 Jun 2026

Scientists Discover a Metabolic Switch That Regulates Ferroptosis

The loss of an enzyme can reprogram cellular metabolism in a way that protects cells from a specific form of cell death. Paradoxically, the presumed blockade of this enzyme has the opposite effect.

1 Jun 2026

AI Designs Custom Miniproteins to Precisely Control Cell Receptors

G protein-coupled receptors, or GPCRs, sit in the plasma membrane, the boundary that defines the inside and outside of a living cell. They communicate with nearly every physiological process in our bodies - from the ability to see and smell, to sensing of adrenaline, insulin, nutrients and medicines.

22 May 2026

Web-Based Platform Facilitates Chemical Structure Queries in Metabolomics

An international team led by researchers at University of California San Diego and University of California, Riverside has developed a free, web‑based platform designed to make public metabolomics data more accessible.

15 May 2026

Animals Adapt Rapidly Through Protein Networks, Not Genes

UT Southwestern Medical Center researchers have discovered a key molecular mechanism that allows animals to adapt to changing environmental conditions without altering their genes – an ability known as phenotypic plasticity.

15 May 2026

Prime Assembly Enables Precise Insertion of Large DNA Segments Into the Genome

Researchers at UMass Chan Medical School have developed a gene editing technology that allows for the precise and efficient insertion of very large DNA segments into the human genome.

13 May 2026

Cryo-EM Study Explains Why Coffee Tastes Bitter to Humans

Have you ever wondered why freshly brewed coffee smells so delicious, but tastes bitter?

12 May 2026

Prime Assembly Approach Transforms Gene Therapy With Large DNA Inserts

New technology enables the insertion of a large segment of DNA into a genome, potentially expanding gene therapy treatment from cancellation of disease-causing mutations to replacement of an entire gene, scientists say.

30 Apr 2026

Proxygen Expands Platform Beyond Degradation to Build Next-Generation Induced Proximity Therapeutics

Proxygen, a biotechnology company pioneering the discovery of molecular glue degraders and next-generation proximity-based therapeutics, today publicly announced the expansion of its platform beyond targeted protein degradation to access a broader range of induced proximity therapeutics, while advancing two lead molecular glue degrader programs toward clinical development.

From Proxygen 29 Apr 2026

High Resolution Images Reveal DNA Repair Process in Key Protein

Scientists have captured the most detailed structural images to date of a specific type of protein's DNA repair process, a finding that could reveal ways to inhibit the effects of BRCA1 and BRCA2 mutations that heighten the risk for breast, ovarian and other cancers.

28 Apr 2026

New Methods Increase Understanding of How Bacteria Manage DNA

New analytical methods developed at Baylor College of Medicine and collaborating institutions have increased our understanding of how bacteria manage DNA.

23 Apr 2026

Structured National Genomic Program can be Effective for Rare Disease Diagnosis

For many families, eight years of uncertainty meant repeated specialist visits, inconclusive genetic tests and the growing fear that a clear answer might never come. For nearly half of the children enrolled in the Telethon Undiagnosed Disease Program (TUDP), that wait is now over.

21 Apr 2026