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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

PLAMseq Revolutionizes Simultaneous Analysis of Genome Proteins and Their Locations

A team from the Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER) has developed an innovative technique called PLAMseq (proximity-labelled affinity-purified mass spectrometry plus sequencing) that, for the first time, allows simultaneous analysis of chromatin-associated proteins and their location in the genome in a single experiment.

5 Dec 2025

Cells Use Condensates to Save RNA Messages During Stress

All cells need to sense and respond to their environment, to know when to activate genes, build proteins, and carry out their basic functions.

4 Dec 2025

New Tool Predicts Which Intrinsically Disordered Regions Drive Condensate Formation

Fusion oncoproteins arise when a gene fuses with another gene and acquires new abilities. Such abilities can include the formation of biomolecular condensates, "droplets" of concentrated proteins, DNA or RNA.

4 Dec 2025

Circular Single-Stranded DNA Molecule Can Simultaneously Silence Multiple MicroRNAs

Professor Dongsheng Liu of Tsinghua University, Professor Ziyang Hao of Capital Medical University, and Researcher Yuanchen Dong of the Institute of Chemistry, Chinese Academy of Sciences, have collaborated to develop a circular single-stranded DNA molecule capable of simultaneously silencing multiple miRNAs.

4 Dec 2025

Study Reveals How Cells Compensate for Missing Chromosomes

A hallmark of cancerous cells is an abnormal number of chromosomes or chromosome arms, known as aneuploidy.

4 Dec 2025

Single-Cell RNA Imaging Uncovers Four Distinct Neuron Bands in the Hippocampus

Researchers at the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC have identified a previously unknown pattern of organization in one of the brain's most important areas for learning and memory.

4 Dec 2025

Study Exposes Ancestry Biases in Current Gene Annotations

Human gene maps contain major blind spots because they were built largely from the DNA sequences of people with European ancestry, according to a study published today in Nature Communications.

4 Dec 2025

Engineered Gut Bacteria With MiRNA Nanoparticles To Reverse IBD

Biomimetic nanoparticles delivering microRNA to gut bacteria enhance protective metabolites, repair intestinal barriers, and alleviate colitis symptoms.

3 Dec 2025

Ambiguous Stop Codons Expand the Genetic Code in Archaea

The beauty of the DNA code is that organisms interpret it unambiguously. Each three-letter nucleotide sequence, or codon, in a gene codes for a unique amino acid that's added to a chain of amino acids to make a protein.

2 Dec 2025

Study Uncovers How Polyploid Plants Harness Transposons for Evolutionary Innovation

Polyploidization, the combination and duplication of genomes, is a major driver of plant evolution and diversification. Yet this process causes "genome shock," leading to rapid activation of transposable elements (TEs).

2 Dec 2025

New Insight Into Light-Guided Growth of Bristleworm Eyes

A new study, led by the University of Vienna and the Alfred Wegener Institute in Bremerhaven, shows how the eyes of adult marine bristleworms continue to grow throughout life – driven by a ring of neural stem cells reminiscent of vertebrate eyes.

2 Dec 2025

CRISPR Technologies Transform On-Site Detection of Animal Pathogens

The rapid spread of animal diseases and pathogen evolution have long posed significant threats to the healthy development of animal husbandry.

28 Nov 2025

Capturing a Self-Splicing Ribozyme in Motion

RNA is a central biological macromolecule, now widely harnessed in medicine and nanotechnology. Like proteins, RNA function often depends on its precise three-dimensional structure.

28 Nov 2025

Real-Time Visualization Reveals the Transcriptional Gearbox

Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing RNA in eukaryotic cells and eventually giving rise to proteins.

28 Nov 2025

New Regulatory Pathway Enhances Key Aroma Compound in Wine Grapes

β-Damascenone is a key norisoprenoid compound responsible for characteristic floral and fruity aromas in grapes and wines, particularly those from non-aromatic varieties such as Cabernet Sauvignon and Merlot.

27 Nov 2025

Gene Transcription Start Sites Identified as Hidden Mutational Hotspots

Researchers have discovered new regions of the human genome particularly vulnerable to mutations. These altered stretches of DNA can be passed down to future generations and are important for how we study genetics and disease.

27 Nov 2025

Mitochondrial Mutation Found to Rewire Immune Function

Scientists have discovered how a mitochondrial mutation rewires immune function in a model of inherited primary mitochondrial disorders, which often lead to severe disability and death.

27 Nov 2025

Scientists Uncover Inner Workings of Biomolecular Condensates Linked to ALS

Inside the cell reside many tiny assembly factories and warehouses that gather together all of the proteins and RNAs-which carry out instructions from our DNA-that a living being needs.

27 Nov 2025

Discovery Reveals Unexpected Role for OTULIN in Controlling Tau Expression

Scientists have uncovered a surprising mechanism by which a brain enzyme called OTULIN controls the expression of tau, the protein that forms toxic tangles in Alzheimer's disease.

26 Nov 2025