Receptor News and Research

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Unusual Antibody Tactics Hinder Pathogen Attachment to Cells

Pathogens can create sticky situations. When microbes invade the body to cause an infection, often one of their first lines of attack is to cling tenaciously to the surfaces of targeted human cells.

8 Jan 2026

Blocking Retinoic Acid Pathway Improves Dendritic Cell Anti-Tumor Function

Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have identified novel mechanisms by which a metabolic derivative of vitamin A-all-trans retinoic acid-compromises both the body's normal anti-cancer immune response and, in a different context, the efficacy of a promising type of cancer vaccine.

6 Jan 2026

Kinetic Traps Explain Differences in GPCR Drug Efficacy

G-protein coupled receptors (GPCRs) are proteins triggered by ligands (protein-binding chemicals) from outside cells to transmit signals inside the cell.

23 Dec 2025

Elusive Kinase State Explains How Cells Achieve Efficient Signaling

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its target, without needing to release

19 Dec 2025

Breaking the Interspecies Immune Barrier to Advance Human Organ Generation

Failure of human pluripotent stem cells (PSCs) to survive when grown with the PSCs of distantly related species occurs because of an innate immune reaction in the nonhuman cells, a study led by UT Southwestern Medical Center researchers suggests.

9 Dec 2025

Restoring Tenascin-C Protein Could Help Prevent Age-Related Muscle Loss

As we age, the muscles we rely on for daily activities tend to become less reliable. With enough decline, even normal movements such as getting out of bed become risky.

8 Dec 2025

New Microscopy Reveals How Cells Actively Capture the Flu Virus

Researchers at ETH Zurich have achieved an unprecedented live, high-resolution visualization of influenza virus infection within living cells.

5 Dec 2025

Study Identifies Adipogenin as Crucial Driver of Lipid Droplet Formation

A microprotein called adipogenin appears to play a key role in helping fat cells store lipid droplets – a phenomenon that's pivotal for metabolic health, a study co-led by UT Southwestern Medical Center researchers shows.

27 Nov 2025

Researchers Develop High-Throughput Technique to Decode T-Cell Receptors

Studying T cells, the immune cells most responsible for responding to infections and cancers, just received a significant boost in the form of a new technique from St. Jude Children's Research Hospital.

25 Nov 2025

Discovery Offers a Potential Way to Boost Tissue Resident Memory T Cell Numbers

We owe a lot to tissue resident memory T cells (TRM). These specialized immune cells are among the body's first responders to disease.

24 Nov 2025

Discovery Connects Dopamine Receptor Desensitization to Everyday Motivational Fatigue

Our brain's reward system processes and reinforces pleasurable experiences, motivating us to seek out and engage in rewarding activities ranging from eating to social interactions to recreational drug use.

21 Nov 2025

New Multi-Target CAR-T Cells Eradicate Glioblastoma in Preclinical Models

With a five-year survival rate of less than 5%, glioblastoma is one of the most aggressive types of brain cancer.

21 Nov 2025

Sabotaging T Cell Exhaustion for Cancer Therapy

Like all hardworking things, the cytotoxic T lymphocytes (CTLs) of the immune system charged with detecting and destroying cancer cells tend to get very tired-so much so, in fact, that they can even die from exhaustion.

18 Nov 2025

Researchers Discover Molecular Switch That Helps Breast Cancer Cells Survive Stress

Cells are regularly faced with environmental stresses that may damage or destroy them. To survive, they quickly adjust their gene expression to protect themselves.

18 Nov 2025

St. Jude Scientists Discover Hidden Binding Pocket in Nuclear Receptors

A study from St. Jude Children's Research Hospital uncovered an alternative binding pocket within nuclear receptors, revealing a much-needed new therapy route for this important class of drug targets.

7 Nov 2025

Comprehensive Kinase Atlas Redefines Regulation of Gene Transcription Machinery

The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme's "tail" called phosphorylation patterns.

7 Nov 2025

RNA Molecules Alter Genome Structure to Silence Critical Neuronal Genes During Stress

What if the brain's response to stress could be read not in fleeting neurotransmitter bursts, but in the quieting of genes deep inside chromatin? Researchers at the University of Alabama at Birmingham have now shown that stress hormones may silence crucial neuronal genes through an unexpected class of RNA molecules that operate not by encoding proteins, but by reshaping the genome's architecture.

5 Nov 2025

Intracellular Compounds Offer Blueprint for Next-Generation Targeted Therapies

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, turning the cell's busiest receptors into precision tools - opening the door to a new generation of safer, smarter medicines.

3 Nov 2025

Breakthrough Small Molecule Offers New Hope for Diabetes Treatment

Researchers from the University at Albany and NYU Grossman School of Medicine have found a way to block a key cellular pathway known to drive chronic inflammation and impaired wound healing in people with diabetes.

31 Oct 2025

AI-Guided Protein Engineering Creates Smart Receptors for Cancer Immunotherapy

Cancer immunotherapy, especially using T cells, is showing a lot of promise in treating blood cancers. Bioengineered T cells, especially those equipped with chimeric antigen receptors (CAR-T cells), have revolutionized cancer treatment.

29 Oct 2025