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New Drug Combo Shows Promise Against Aggressive Leukemia in Landmark Study

A novel drug combination targeting LSD1 and GSK3 shows promise in treating acute myeloid leukemia by promoting cell differentiation and reducing tumor growth.

28 Apr 2025

Guinea Pig Modeling To Study Human Preimplantation and Embryogenesis

Research on guinea pig embryos uncovers similarities to human embryogenesis, advancing understanding of preimplantation stages and reproductive techniques.

23 Apr 2025

New Research Further Translates the Language of the Genome

New research has uncovered more about the complexity of human gene regulation by identifying certain sequences of proteins called transcription factors that bind to DNA and regulate the expression of human genes.

9 Apr 2025

UV Light Reshapes 3D Genome Structure, Altering DNA Repair and Gene Activity

Research shows UV radiation modifies 3D genome structure, affecting DNA damage response and gene activity, offering insights for cancer prevention strategies.

24 Mar 2025

Researchers Identify Promising Drug Candidates for Previously “undruggable” Cancer Target

For the first time scientists have identified promising drug candidates that bind irreversibly with a notoriously “undruggable” cancer protein target, permanently blocking it.

21 Mar 2025

New Technique Converts Skin Cells into Motor Neurons

Converting one type of cell to another - for example, a skin cell to a neuron - can be done through a process that requires the skin cell to be induced into a "pluripotent" stem cell, then differentiated into a neuron.

14 Mar 2025

Can We Engineer Crops to Withstand Climate Change and Increasing Temperatures?

Investigating heat stress in crops, this review highlights genetic adaptations and CRISPR techniques to develop resilient varieties for sustainable agriculture.

12 Mar 2025

Investigating Ubiquitination's Role in Cancer Stem Cell Regulation

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), shedding light on potential therapeutic targets for combating tumor progression, recurrence, and drug resistance.

10 Mar 2025

New Approach Could Protect Insulin-Producing Beta Cells from Damage Related to Diabetes

Researchers from the Icahn School of Medicine at Mount Sinai in New York have discovered a novel approach to protecting insulin-producing beta cells from the damaging effects of glucolipotoxicity-a harmful condition linked to the progression of type 2 diabetes (T2D).

5 Mar 2025

Unlocking the Role of lncRNAs in MASLD and Liver Fibrosis

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed non-alcoholic fatty liver disease (NAFLD), represents a widespread health concern, impacting approximately 30% of the global adult population.

3 Mar 2025

Novel Mechanism of mRNA Transfer via Tunneling Nanotubes Discovered

Cell-to-cell communication is crucial in all forms and stages of life, and various communication mechanisms have been extensively researched.

20 Feb 2025

EpiBERT AI Model Reveals How Genes Are Regulated in Human Cells

A team of investigators from Dana-Farber Cancer Institute, The Broad Institute of MIT and Harvard, Google, and Columbia University have created an artificial intelligence model that can predict which genes are expressed in any type of human cell.

30 Jan 2025

GET Model Unveils Gene Regulation with Unmatched Accuracy Across Cell Types

GET, a novel computational model, accurately predicts gene activity by analyzing chromatin accessibility and DNA sequences across diverse human cell types.

20 Jan 2025

Plant Research Reveals Unexpected Function for Key Cellular Protein

A cell protein previously believed only to provide a scaffolding for DNA has also been shown to directly influence DNA transcription into RNA – the first step of the process by which an organism's genetic code expresses itself. The fundamental breakthrough was discovered in apple cells but is relevant to all living organisms made of nucleus-containing cells, including humans.

24 Dec 2024

Discovery of START Domain Reveals Secrets of Plant Development

Within all complex, multicellular living systems such as plants and humans, there exists a set of genetic elements that can be likened to the blueprints, tools, and specialized personnel at a construction site for an expanding development.

6 Dec 2024

Cancer-Associated Gene MYC Found to Drive Muscle Growth Independently of Exercise

Researchers have long known that there is a relationship between the cancer-associated gene MYC (pronounced "Mick") and exercise adaptation.

4 Dec 2024

The Role of RNA Polymerase and Ribosomes in Gene Expression

DNA within a cell contains the genetic instructions necessary for building proteins.

29 Nov 2024

Study Reveals Molecular Mechanism Behind Neural Fate Commitment

The Wistar Institute's Alessandro Gardini, Ph.D., and lab have shed new light on how certain biological processes determine the development of neural cells. Their findings on a molecular "bridge" complex demonstrate a new level of detail in the understanding of early neural development -; which is fundamental for the further understanding of neurodevelopmental syndromes.

27 Nov 2024

Novel Mechanism Revealed for Zygotic Genome Activation in Drosophila

Early development of an embryo is solely supported by maternally deposited RNAs and proteins until its own genome is activated through a process called zygotic genome activation (ZGA).

20 Nov 2024

Understanding Marine Worms’ Unique Ability to Regenerate Lost Body Parts

Many living organisms are able to regenerate damaged or lost tissue, but why some are particularly good at this and others are not is not fully understood.

19 Nov 2024