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How Domestication Changed Cat Genes and Behavior

Whether one is fortunate enough to have a cat friend or must enjoy the experience vicariously through cat videos, Felis catus is a familiar and reassuring presence in our daily lives.

30 May 2025

Study Identifies SMARCB1 and MEOX2 Genes as Growth Regulators of Lung Cancers

A Cancer Gene Therapy study reveals that MEOX2 promotes lung cancer progression while SMARCB1 acts as a tumor suppressor, influencing EGFR expression and response to tyrosine kinase inhibitors.

30 May 2025

Herpes Virus Protein Enhances T-Cell Survival for Cancer Therapy

Recent studies reveal the herpes virus may enhance cancer treatment by activating T cell pathways, improving immunotherapy effectiveness against tumors.

29 May 2025

Unraveling the Mysteries of the Barr Body and Aging

Aging in female mice shows increased gene activity on the second X chromosome, offering insights into cardiovascular disease and neurodegenerative disorders.

28 May 2025

Study Reveals How APOE Isoforms Impact Brain Microglia

A study reveals how APOE isoforms influence microglial activity in Alzheimer's, highlighting the need for targeted interventions based on genetic risk factors.

28 May 2025

Cobraa: A Coalescence-Based Model Infers a Structured Ancestry Shared by Modern-Day Humans

The Cobraa model offers insights into human evolution, detailing ancestral population dynamics and genetic admixture events over the last 1.5 million years.

28 May 2025

Epigenome Editing: Enhancing Endonuclease Protein Design for In Vivo Applications

Researchers have engineered a compact, high-specificity IscB variant, NovaIscB, for safe, persistent in vivo epigenome editing using AAV delivery, offering a powerful tool for gene regulation without DNA breaks.

28 May 2025

Study Challenges Longstanding Mitochondrial Theory of Aging

The human genome is broadly classified into the genome residing in the cell nucleus (nuclear DNA) and the genome residing in the mitochondria (mitochondrial DNA: mtDNA). Mitochondria are cell organelles that produce energy essential for life activities through oxidative phosphorylation (mitochondrial respiration), and mtDNA encodes a set of genes required for mitochondrial respiration.

27 May 2025

Mutation Profiling Reveals Therapeutic Targets in Lung Squamous Cell Carcinoma

Lung Squamous cell carcinoma (LSCC) represents the second most common non-small cell lung cancer. Although studies identified adenocarcinoma-like driver mutations in LSCC using next-generation sequencing (NGS), the disease is challenging to treat due to the limited number of detectable mutations for targeted drug therapy.

27 May 2025

RNA Editing and Transcriptional Switching Shape Fungal Antiviral Response

The expression of symptoms of viral infections is a byproduct of complex virus-host molecular pathways. These remain largely unknown, especially in the case of fungus-virus pathogen systems.

24 May 2025

New Genomic Score Predicts Risk of Progression in Multiple Myeloma

A new risk assessment score developed by researchers at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard reveals how multiple myeloma, a form of blood cancer, begins and progresses from precancerous to malignant states by tracing DNA mutations.

24 May 2025

Gene Loss and Gain Shaped the Evolution of Relapsing Fever Bacteria

Researchers at the Francis Crick Institute and UCL have analyzed ancient DNA from Borrelia recurrentis, a type of bacteria that causes relapsing fever, pinpointing when it evolved to spread through lice rather than ticks, and how it gained and lost genes in the process.

24 May 2025