Glycolysis News and Research

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Glycolysis is a series of reactions that helpextract energy from glucose. This is an ancient pathway of metabolism that is present in the majority of living organisms today. It is the foundation of both aerobic and anaerobic cellular respiration. It takes place in the cytosol of a cell and is the foundation of both aerobic and anaerobic cellular respiration.

Combating Tumor Resistance and Exhaustion in Lymphoma

The study reviews CAR-T cell advancements in lymphoma treatment, addressing T cell exhaustion and tumor immune evasion with next-generation CAR modifications.

24 Jun 2025

Cryo-EM/ET Reveals Dynamic Architecture of Key Metabolic Enzyme

Recent cryo-EM research reveals the dynamic architecture of the pyruvate dehydrogenase complex, enhancing understanding of its role in metabolism and disease.

2 Jun 2025

Zebrafish Study Warns of Ecological Risk from Tire-Related Water Contaminants

Emerging contaminants from rubber tires N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPDQ)-are raising new red flags for aquatic ecosystems.

20 May 2025

Unraveling the Role of Long Noncoding RNAs in the Tumor Microenvironment

The tumor microenvironment (TME) is a complex and dynamic network consisting of tumor cells, immune cells, stromal cells, extracellular matrix (ECM), cytokines, and growth factors, all interacting to influence tumorigenesis, progression, and metastasis.

25 Apr 2025

Macrophages Use Bacterial Debris To Fine-Tune Immune Responses

Findings reveal macrophages' role in immune modulation through bacterial metabolites, paving the way for improved therapies for infections and inflammation.

6 Mar 2025

Research Reveals Regulatory Role of Glucose-6-Phosphate Dehydrogenase in Mitophagy

Mitophagy is a selective form of autophagy via which the damaged mitochondria are cleared via the autophagy-lysosome pathway.

30 Dec 2024

Study Reveals Mechanism Behind T Cells' Cancer-Killing Power in Hypoxia

Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has plateaued due to therapeutic resistance that renders tumor-infiltrating lymphocytes, or TILs, ineffective.

16 Dec 2024

Comprehensive Review of Intracellular Checkpoints in NK Cell Biology and Cancer

Natural killer (NK) cells play an important role in the innate immune response to cancer and viral infections, and their presence in tumors correlates with improved patient outcomes in a variety of cancers.

29 Nov 2024

New Insights Into the Role of p53 in Intestinal Inflammation

A group of scientists from Charité – Universitätsmedizin and the Berlin Institute for Medical Systems Biology of the Max Delbrück Center have provided fresh insight into the pathophysiology of ulcerative colitis an inflammatory bowel disease that affects an estimated five million people globally and is associated with a higher risk of colon cancer.

28 Oct 2024

Bifidobacterium in Maternal Gut Found to Alter Fetal Brain Growth

Bifidobacterium breve supplementation in pregnant mice alters fetal brain metabolism, highlighting its role in enhancing gestational health and development.

29 Aug 2024

DeepEvo: Revolutionizing Protein Engineering with Artificial Intelligence

Engineering proteins for desirable traits has been the holy grail of modern biotechnology.

1 Jul 2024

Nutrient Nanomedicine Shows Promise Against Skin Cancer

An international research team has discovered a new way to effectively treat cancer, by using nutrients to reactivate suppressed metabolic pathways in cancer cells.

18 Jun 2024

Mitochondria Influence the Ability of Adult Cardiac Cells to Multiply

Whether forcing adult cardiomyocytes to reverse from the oxidative phosphorylation phenotype to the glycolysis phenotype would also restore their mitotic ability.

13 Jun 2024

Brain Organoids Emerge as Powerful Tool for Drug Discovery in Mitochondrial Disease

The use of brain organoids in screening for drugs against mitochondrial diseases, which have hitherto presented challenges in treatment.

4 Jun 2024

Glycosylation and its Role in Human Health and Disease

The current understanding of glycosylation genetics in mammals and the consequences of mutations that impact glycosylation.

16 May 2024

Study Demonstrates How the Warburg Effect is Crucially Linked to Cancer Progression

Researchers have revealed crucial insights into how the Warburg effect causes the dedifferentiation of cancer cells through epigenetic reprogramming.

3 May 2024

Blockchain Fuels Search for Origins of Metabolism

Researchers from the Korea Institute for Basic Science and the Polish Academy of Sciences have utilized blockchain technology to simulate prebiotic chemical reactions on early Earth.

25 Jan 2024

New Insights Into Lactate Transporters and Their Therapeutic Potential

Researchers from the Giulio Superti-Furga Lab at CeMM, the Austrian Academy of Sciences’ Research Center for Molecular Medicine, have developed a new technique for identifying specific inhibitors of a lactate transporter linked to cancer and other diseases.

31 Jul 2023

New Study Identifies Aerobic Glycolysis Vital for Eye Development

According to a recent Northwestern Medicine study published in Nature Communications, aerobic glycolysis, the process by which cells convert glucose into lactate, is essential for eye development in mammals.

17 Jul 2023