Kinase News and Research

RSS

Manipulating immune cells to suppress the growth of some solid tumors

Cancer researchers at the Case Western Reserve University School of Medicine say they have successfully suppressed the growth of some solid tumors in research models by manipulating immune cells known as a macrophages.

21 Apr 2022

New protective mechanism against non-alcoholic fatty liver disease identified

Non-alcoholic fatty liver disease (NAFLD), commonly known as fatty liver disease, is a prevalent disease frequently seen in obese people. Having high fat content in the liver is detrimental as it is strongly associated with severe health problems like diabetes, high blood pressure, and liver cancer.

20 Apr 2022

Epigenetic regulator helps determine lung cancer patients and their resistance to drugs

Doctors commonly use tyrosine kinase inhibitors, particularly epidermal growth factor receptor inhibitors, to cure patients with non-small cell lung cancer, a common and typically deadly kind of cancer that accounts for 80% to 85% of lung cancers.

20 Apr 2022

Rewiring the inner workings of leukemia cells to reverse drug resistance

Researchers from Barts Cancer Institute at Queen Mary University of London have identified a way to reverse resistance to a group of cancer drugs, known as kinase inhibitors, in leukemia cells.

20 Apr 2022

Max Planck researchers reveal the structure of kinetochore corona

During cell division in a mother cell, the 23 chromosomes that carry the human genome must be first copied and later delivered to two newly forming daughter cells.

From The Max Planck Institute 11 Apr 2022

Understanding how cleaning up bad mitochondria affects stem cell division

Most of us remember enough biology to recall that mitochondria are known as "the powerhouse of the cell." Even that audacious term may downplay the importance of mitochondria and what happens when mitochondria go bad.

1 Apr 2022

ATM kinase inhibitor combines with target therapies to wipe out cancer cells

While cancer therapies that target specific genes or disease pathways might prolong life span, they can also result in highly resistant tumors when tiny reservoirs of cancer cells survive therapy, develop, and spread.

1 Apr 2022

Study shows the impact of ATP binding in human integrin-linked kinase and cell behavior

Getting from point A to point B might be difficult, especially for mobile cells.

21 Mar 2022

New database provides extensive information on kinase-associated neural protein phosphorylation

Biological functions rely on accurate cellular communication involving different molecules. Most major signaling pathways involved in such communication, called signal transduction, often involve a family of kinases—enzymes catalyzing the transfer of phosphates between specific substrate molecules.

17 Mar 2022

Researchers show how hotspot maps can detect structures contributing to compounds’ selectivity

The quantity of structural data available on protein drug targets keeps growing.

4 Mar 2022

Attacking a protein in prostate cancer cells stops the disease spread, research finds

Cedars-Sinai scientists discovered that attacking a protein present in prostate cancer cells could stop the disease from further spreading to various other parts of the body.

2 Mar 2022

Researchers analyze how RNA molecules control the repair of damaged DNA in cancer cells

A new study from Sweden’s Karolinska Institute demonstrates how some RNA molecules regulate the repair of damaged DNA in cancer cells.

25 Feb 2022

Study offers insight into how activated protein C may protect aging patients from reperfusion injury

A University of South Florida Health (USF Health) preclinical study offers molecular insight into how activated protein C (APC) may improve aging patients' tolerance to reperfusion injury – a potentially adverse effect of treatment for ischemic heart disease.

1 Feb 2022

CSHL researchers spotlight the role of a previously little-known protein in leukemia

Acute myeloid leukemia (AML) is an aggressive cancer of white blood cells with few effective targeted therapies available to treat it.

12 Jan 2022

Genes key to microbial colonization of plant roots discovered

Some microbes can form thin films called biofilms. These biofilms give them an advantage over other microbes by protecting them from stresses such as a lack of nutrients or the presence of harmful substances in the environment.

24 Dec 2021

Researchers uncover a new signaling pathway essential for T cell viability

They are at the forefront in the fight against viruses, bacteria, and malignant cells: the T cells of our immune system. But the older we get, the fewer of them our body produces.

23 Dec 2021

Study uncovers mechanism that triggers cancer cell death

Scientists recently pinpointed the mechanism by which inhibitors of the ERK5 protein kinase diminish cancer cell proliferation and trigger their death.

23 Dec 2021

Gene mutation for Parkinson's disease drives mislocalization of iron in activated microglia

A common gene mutation for Parkinson's disease drives mislocalization of iron in activated microglia, according to a new study publishing December 16th in the open-access journal PLOS Biology, by Mark Cookson of the National Institute on Aging and colleagues.

17 Dec 2021

New mechanism makes cells under stress conditions stop their polarized growth

The Oxidative Stress and Cell Cycle Research Group at UPF has discovered a mechanism whereby cells under stress conditions stop their polarized growth. The study, published in the journal Cell Reports, was led by Elena Hidalgo and José Ayté, and the first author is Clàudia Salat-Canela.

13 Dec 2021

Study provides vital information on how plants manage stress

Recent research carried out at the University of Seville, offers new information to comprehend how plants handle stressful situations.

25 Nov 2021

Kinase News and Research

Manipulating immune cells to suppress the growth of some solid tumors

New protective mechanism against non-alcoholic fatty liver disease identified

Epigenetic regulator helps determine lung cancer patients and their resistance to drugs

Rewiring the inner workings of leukemia cells to reverse drug resistance

Max Planck researchers reveal the structure of kinetochore corona

Understanding how cleaning up bad mitochondria affects stem cell division

ATM kinase inhibitor combines with target therapies to wipe out cancer cells

Study shows the impact of ATP binding in human integrin-linked kinase and cell behavior

New database provides extensive information on kinase-associated neural protein phosphorylation

Researchers show how hotspot maps can detect structures contributing to compounds’ selectivity

Attacking a protein in prostate cancer cells stops the disease spread, research finds

Researchers analyze how RNA molecules control the repair of damaged DNA in cancer cells

Study offers insight into how activated protein C may protect aging patients from reperfusion injury

CSHL researchers spotlight the role of a previously little-known protein in leukemia

Genes key to microbial colonization of plant roots discovered

Researchers uncover a new signaling pathway essential for T cell viability

Study uncovers mechanism that triggers cancer cell death

Gene mutation for Parkinson's disease drives mislocalization of iron in activated microglia

New mechanism makes cells under stress conditions stop their polarized growth

Study provides vital information on how plants manage stress

Quorum Bio: Where Synthetic Biology Meets Sustainable Farming

Diagnostic Biochips: Pioneering Brain Research Tools for the Future

Commercializing Innovation in a Life Sciences Ecosystem

Latest in Genomics