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Key Event that Controls the Timing of the Biological Clock Identified

Molecular clocks in our cells synchronize our bodies with the cycle of night and day, cue us for sleep and waking, and drive daily cycles in virtually every aspect of our physiology. Scientists studying the molecular mechanisms of our biological clocks have now identified a key event that controls the timing of the clock.

23 May 2023

Stimulating Cell DNA Repair Processes to Combat the Root Cause of Autism Spectrum Disorders

A new treatment option has been discovered for fragile X syndrome, which is the most common genetic cause of autism spectrum disorders and is defined by a hereditary repetition of certain nucleotides in the DNA sequence of the FMR1 gene. Researchers at Massachusetts General Hospital (MGH) carried out the study, which was published in the journal Cell.

22 May 2023

Machine Learning Reveals Sex-Specific Genes, Molecular Pathways Linked to Alzheimer's Disease Progression

Alzheimer's Disease (AD) is a complex neurodegenerative illness with genetic and environmental origins.

22 May 2023

Pancreatic Cancer Cells Use a New Nutrient Source to Grow, Study Finds

Researchers at the University of Michigan Rogel Cancer Center have discovered a new nutrient source that pancreatic cancer cells use to grow.

18 May 2023

Long-Ignored Antibiotic may Provide Much-Needed Protection Against Multi-Drug Resistant Bacteria

An old antibiotic may provide much-needed protection against multi-drug resistant bacterial infections, according to a new study publishing May 16th in the open access journal PLOS Biology by James Kirby of Harvard Medical School, US, and colleagues.

17 May 2023

Study Demonstrates the First Molecular Link Between Circatidal and Circadian Clocks

Scientists at UMass Chan Medical School and the Marine Biological Laboratory at Woods Hole have identified the first gene-; Bmal1-; to play a crucial role in regulating circatidal behavior in the crustacean Parhyale hawaiensis.

12 May 2023

Study Reveals an Immunological Strategy to Overcome Microbiome-Related Immunotherapy Resistance

Cancer immunotherapy has transformed the treatment of many types of cancer. Yet, for reasons that remain poorly understood, not all patients get the same benefit from these powerful therapies.

4 May 2023

How Bacteria Take Action to Break Out of Dormancy

Solving a riddle that has confounded biologists since bacterial spores -; inert, sleeping bacteria -; were first described more than 150 years ago, researchers at Harvard Medical School have discovered a new kind of cellular sensor that allows spores to detect the presence of nutrients in their environment and quickly spring back to life.

2 May 2023

Study Uncovers Somatic Mutations That Play a Role in Common Form of Adult Epilepsy

Epilepsy affects approximately 1-in-26 people and the most common form, known as temporal lobe epilepsy (TLE), often cannot be adequately treated with anti-seizure medications.

2 May 2023

New Gene Therapy may be on the Horizon for Usher Syndrome Type 1F

Usher Syndrome type 1F is a rare but severe genetic disease that causes deafness, lack of balance, and progressive blindness.

27 Apr 2023

Interpreting Mutations in Disease Genes and Improving Clinical Decision-Making

DeMAG is a new method that was developed by Max Planck and Harvard’s research team. It is a new technique that has been shared as an open-source web server (demag.org) to assist interpret mutations in disease genes and enhance clinical decision-making.

26 Apr 2023

Generating the Landscape of m6A in a Mouse Embryo

RNA, particularly mRNA, has recently received some attention as the major component of the COVID-19 vaccines.

26 Apr 2023

Researchers Identify Novel Role of a Protein in the Development of Alcohol-Associated Liver Disease

Alcohol-associated liver disease (ALD), a complex disorder that occurs in some patients who have engaged in excessive alcohol use, is one of the leading causes of chronic liver disease among veterans and liver transplant patients in the United States.

19 Apr 2023

Entry of Aging-Associated Enzymes into Human Genetic Material

An enzyme that controls aging and other metabolic processes accesses human genetic material to modify gene expression within the cell, according to a new study. Images of a sirtuin enzyme bound to a nucleosome, a tightly packed complex of DNA and proteins called histones, have been created by a team led by Penn State researchers.

17 Apr 2023

Glycine-Based Tripeptide Treats Severe Form of Fatty Liver Disease in Non-Human Primates

A recently developed amino acid compound successfully treats nonalcoholic fatty liver disease in non-human primates -; bringing scientists one step closer to the first human treatment for the condition that is rapidly increasing around the world, a study suggests.

11 Apr 2023

Medical School News and Research

Key Event that Controls the Timing of the Biological Clock Identified

Stimulating Cell DNA Repair Processes to Combat the Root Cause of Autism Spectrum Disorders

Machine Learning Reveals Sex-Specific Genes, Molecular Pathways Linked to Alzheimer's Disease Progression

Pancreatic Cancer Cells Use a New Nutrient Source to Grow, Study Finds

Long-Ignored Antibiotic may Provide Much-Needed Protection Against Multi-Drug Resistant Bacteria

Study Demonstrates the First Molecular Link Between Circatidal and Circadian Clocks

Study Reveals an Immunological Strategy to Overcome Microbiome-Related Immunotherapy Resistance

How Bacteria Take Action to Break Out of Dormancy

Study Uncovers Somatic Mutations That Play a Role in Common Form of Adult Epilepsy

New Gene Therapy may be on the Horizon for Usher Syndrome Type 1F

Interpreting Mutations in Disease Genes and Improving Clinical Decision-Making

Generating the Landscape of m6A in a Mouse Embryo

Researchers Identify Novel Role of a Protein in the Development of Alcohol-Associated Liver Disease

Entry of Aging-Associated Enzymes into Human Genetic Material

Glycine-Based Tripeptide Treats Severe Form of Fatty Liver Disease in Non-Human Primates

Research Reveals Why Viruses can Reinfect a Population of Previously Immune Hosts

Analyzing the Connection Between Genes, Brain Characteristics, and Behavior

Role of Engineered E. coli in Sending Therapeutic Nanobodies to the Gut

Cellular Recycling Function in the Brain Slows Dramatically After Traumatic Brain Injury

Dengue Viruses Subvert Mosquito Biology to Tamp Down Human Immune Responses

CITES: Regulating the International Wildlife Trade to Preserve the Viability of Species

How can the adoption of AI technology accelerate drug discovery?

Gaining insights into human disease biology through CRISPR platforms

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