Metabolism News and Research

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Metabolism is the means by which the body derives energy and synthesizes the other molecules it needs from the fats, carbohydrates and proteins we eat as food, by enzymatic reactions helped by minerals and vitamins.

Can We Engineer Crops to Withstand Climate Change and Increasing Temperatures?

Investigating heat stress in crops, this review highlights genetic adaptations and CRISPR techniques to develop resilient varieties for sustainable agriculture.

12 Mar 2025

Scientists Develop Off-the-Shelf Vascular Grafts Using Stem Cells

Zhang, J., et al. (2025) Small-diameter artery grafts engineered from pluripotent stem cells maintain 100% patency in an allogeneic rhesus macaque model. Cell Reports Medicine. doi.org/10.1016/j.xcrm.2025.102002.

12 Mar 2025

Microbiome-Based Approach Shows Promise for Treating Ulcerative Colitis

The human gut is home to trillions of bacteria that play vital roles in digestion, immunity, and overall health.

12 Mar 2025

Sulfate-Reducing Bacteria Play Key Role in Global Carbon Breakdown

Sulfate-reducing bacteria break down a large proportion of the organic carbon in oxygen-free zones of the Earth, and in the seabed in particular.

10 Mar 2025

New Method Creates Stable Fatty Acid Solutions for Biological Research

FAs are important in cellular processes such as membrane structure, energy storage, and signaling. However, challenges remain in preparing stable FA solutions due to their amphipathic nature and low solubility in water.

6 Mar 2025

Macrophages Use Bacterial Debris To Fine-Tune Immune Responses

Findings reveal macrophages' role in immune modulation through bacterial metabolites, paving the way for improved therapies for infections and inflammation.

6 Mar 2025

Neural Mechanism Involved in Leptin Resistance Revealed

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category.

5 Mar 2025

New Approach Could Protect Insulin-Producing Beta Cells from Damage Related to Diabetes

Researchers from the Icahn School of Medicine at Mount Sinai in New York have discovered a novel approach to protecting insulin-producing beta cells from the damaging effects of glucolipotoxicity-a harmful condition linked to the progression of type 2 diabetes (T2D).

5 Mar 2025

Colossal Creates the Colossal Woolly Mouse, Showcasing Breakthroughs in Multiplex Genome Editing and Trait Engineering on the Path to a Mammoth

In an extraordinary achievement of advanced multiplexed genome engineering, Colossal Biosciences announces the birth of the Colossal Woolly Mouse—mice engineered to express multiple key mammoth-like traits that provide adaptations to life in cold climates.

5 Mar 2025

Synthetic Microbiome Treatment Prevents C. difficile Infection in Mice

A synthetic microbiome therapy, tested in mice, protects against severe symptoms of a gut infection that is notoriously difficult-to-treat and potentially life threatening in humans, according to a team of researchers at Penn State.

4 Mar 2025

Gut Microbes Transform Excreted Glucose into Crucial Fatty Acids

Gut microbes that were thought to feed exclusively on dietary fiber also get fed sugar from our guts, from which they produce short-chain fatty acids that are crucial to many body functions.

4 Mar 2025

Lactylation Levels Influence Cardiac Development and Regeneration in Mice

This study is led by Dr. Xiaodong Luan (Institute of Clinical Medicine, Peking Union Medical College Hospital), Dr. Shuyang Zhang (Department of Rare Diseases, Peking Union Medical College Hospital) and Dr. He Huang (Shanghai Institute of Materia Medica, Chinese Academy of Sciences).

3 Mar 2025

Quantifying 3D Cell Shape During Early Development

For the last three decades, biologists and computer scientists have dedicated significant effort to quantifying the 3D shape of cells and analyzing their interactions.

3 Mar 2025

Unraveling PDMA's Influence on Rhizosphere Microbial Communities

The rhizosphere is influenced by a range of exudates released by plant roots. These root exudates serve as an “intermediary” between the plant and the soil, modifying the root's immediate environment.

3 Mar 2025

Unlocking the Role of lncRNAs in MASLD and Liver Fibrosis

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed non-alcoholic fatty liver disease (NAFLD), represents a widespread health concern, impacting approximately 30% of the global adult population.

3 Mar 2025

Unlocking Cancer’s Secret Strategy: Tumor Cells Work Together To Survive

Research uncovers tumor cell cooperation via CNDP2, suggesting new therapeutic strategies that disrupt nutrient sharing to inhibit cancer growth effectively.

25 Feb 2025

LUC7 Proteins Play Key Role in RNA Splicing Control

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns, are cut out and the coding portions are spliced back together.

21 Feb 2025

New Discoveries Challenge Textbook Knowledge of Mitochondrial Respiration

In an article published in the journal Trends in Biochemical Sciences, Alicia Kowaltowski, full professor at the University of São Paulo's Institute of Chemistry (IQ-USP) in Brazil, advocates the "rewriting" of textbooks on the location of the electron transport chain in mitochondria and the role of sodium in mitochondrial respiration.

20 Feb 2025

Circadian Rhythms Play a Key Role in Teen Eating Habits and Obesity

Researchers found that teens with obesity ate more later in the day than their peers of healthy weight, and that their eating behaviors were strongly influenced by their internal body clock.

18 Feb 2025

New Study Uncovers Evolutionary Link in B6 Metabolism

An investigation conducted by a group of scientists at the University of Kentucky’s Martin-Gatton College of Agriculture, Food and Environment has uncovered an unexpected biochemical link between the immune responses of plants and the neurological health of humans.

18 Feb 2025