Metabolism News and Research

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Metabolism is the means by which the body derives energy and synthesizes the other molecules it needs from the fats, carbohydrates and proteins we eat as food, by enzymatic reactions helped by minerals and vitamins.

Chromosome Imbalance Disrupts Mitochondria Through Protein Aggregates

It has been known for several years that abnormal chromosome numbers lead to protein imbalances in the affected cells. Researchers at RPTU have now investigated the detailed effects of such imbalances.

30 Jun 2025

Yeast Model Offers Insight Into Proteasome and Mitochondria Interplay

A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating the interaction between the proteasome and mitochondrial function.

30 Jun 2025

Reactivating a Genetic Switch Restores Ear Regeneration in Mice

By flipping an evolutionarily disabled genetic switch involved in Vitamin A metabolism, researchers have enabled ear tissue regeneration in mice. Unlike some animals such as fish and salamanders, mammals have limited capacity to regenerate damaged tissues or organs fully.

27 Jun 2025

LMU Study Reveals How Life Could Begin Without Cell Membranes

LMU researchers have demonstrated a possible mechanism for metabolic processes without cell membranes in water-filled pores.

27 Jun 2025

Genetically Similar Bacteria Show Unexpected Diversity in Shape and Behavior

Genetically similar bacteria can differ in shape and behavior, even in lab settings. A recent study shows that this variability impacts microbial fitness, virulence, and our understanding of gut microbiota.

26 Jun 2025

RNases Play Pivotal Role in Shaping the Molecular Foundation of Mendelian Disorders

A new review brings to light the pivotal role of ribonucleases (RNases) in shaping the molecular foundation of Mendelian disorders.

26 Jun 2025

Combating Tumor Resistance and Exhaustion in Lymphoma

The study reviews CAR-T cell advancements in lymphoma treatment, addressing T cell exhaustion and tumor immune evasion with next-generation CAR modifications.

24 Jun 2025

Study Reveals TRF's Role in Reshaping Gut Microbiome and Metabolism

Metatranscriptomics uncovers how time-restricted feeding restores gut microbial cycles, offering insights into improving metabolic health and disease treatment.

20 Jun 2025

Organotypic Model of the Human Gut Epithelium Demonstrates Genetic Determinants of Shigella Colonization

A study in Nature Genetics uses organotypic gut models to reveal genome-wide genetic determinants of Shigella colonization, spotlighting type III secretion system effectors as crucial for early infection.

20 Jun 2025

Ancient Immune Sensor STING Found to Regulate Gut Microbe Tolerance

Thousands of bacterial and other microbial species live in the human gut, supporting healthy digestion, immunity, metabolism and other functions.

18 Jun 2025

The Role of Metabolism in Bacterial Survival and Resistance

Ciprofloxacin induces bioenergetic stress in E. coli, boosting survival rates and resistance development. Metabolic shifts challenge antibiotic effectiveness.

10 Jun 2025

Giant Viruses Discovered to Influence Marine Ecosystems and Algal Blooms

Giant viruses play a role in the survival of single-celled marine organisms called protists. These include algae, amoeba, and flagellates, that form the base of ocean food webs.

9 Jun 2025

New Study Reveals Itaconate’s Crucial Functions in Plants

Zhang, T., et al. (2025) The metabolite itaconate is a transcriptional and posttranslational modulator of plant metabolism, development, and stress response. Science Advances. doi.org/10.1126/sciadv.adt7463.

9 Jun 2025

PPP2R1A Gene Mutations Improve ATR Inhibitor Drug Effectiveness in Ovarian Clear Cell Cancers

A study in Oncogene shows that PPP2R1A mutations increase sensitivity to ATR inhibitors in ARID1A-mutant ovarian clear cell carcinoma, suggesting a potential biomarker for improved treatment strategies.

5 Jun 2025

Light-Controlled Phagobots Offer Precision Immune Modulation

Macrophages and other immune cells are the natural frontline immune warriors of our body, defending the body against invading pathogens and cancer cells.

2 Jun 2025

Exploring the Metabolic Pathways of Cancer Cells

Research from the University of Cincinnati reveals how the MYC oncogene alters PRPS enzymes, impacting redox homeostasis and lymphoma progression.

30 May 2025

New Insights into the Molecular Fight or Flight Reset

Being cut off in traffic, giving a presentation or missing a meal can all trigger a suite of physiological changes that allows the body to react swiftly to stress or starvation.

30 May 2025

Protein Mapping Uncovers 'Molecular Fingerprint' for Insulin Sensitivity

Scientists have unearthed surprising details about how our bodies handle insulin – the hormone that plays a crucial role in regulating blood sugar and developing diabetes.

28 May 2025

Exploring the Flexible Structure of Sulfite Reductase Enzyme

Visualization of sulfite reductase's structure offers insights into sulfur chemistry, aiding in drug development and understanding bacterial energy sources.

28 May 2025

Study Shows How Age-Related Metabolic Decline Impairs the Efficacy of CAR-T Cell Therapy

A Ludwig Cancer Research study has discovered that the metabolic decline that accompanies aging impairs the efficacy of CAR-T cell therapy, an immunotherapy in which T cells of the immune system are taken from patients, engineered to target cancer cells and reinfused into the same patients for treatment.

26 May 2025