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New gene therapy could help treat Duchenne muscular dystrophy

Researchers from UT Southwestern used a new kind of gene therapy to successfully treat mice with Duchenne muscular dystrophy (DMD), distinctively employing CRISPR-Cas9-based tools to restore a large section of the dystrophin protein missing in several DMD patients.

3 May 2021

Cell adaptation to adverse conditions could differentiate survivors and non-survivors of critical illness

Creating the best conditions for cells to make energy and survive critical illness is a challenge little understood in modern medicine.

27 Apr 2021

Protein in skeletal muscular system may play a key role in the body's fight or flight response

Researchers at the University of Cincinnati say a regulatory protein found in skeletal muscle fiber may play an important role in the body's fight or flight response when encountering stressful situations.

26 Apr 2021

Macrophages perform necessary damage-control function following tissue injury

Cardiovascular disease, the most common cause of death, is the result of oxygen deprivation as blood perfusion to affected tissue is prevented. To halt the development of the disease and to promote healing, re-establishment of blood flow is crucial.

26 Apr 2021

Obesity reduces mitochondrial gene expression in fat tissues

A university has recently completed a study that suggests that the machinery responsible for handling the energy in fat tissues is performing poorly in obesity.

12 Apr 2021

New technique improves single-cell transcriptomics

With the help of single-cell transcriptomic techniques, researchers can study an unlimited number of individual cells from living organisms one at a time.

8 Apr 2021

Study identifies multiple genes that are frequently mutated in uterine leiomyosarcomas

In a new study, Yale Cancer Center researchers have defined the genetic landscape of uterine leiomyosarcomas (uLMS).

6 Apr 2021

New study could help develop cultured meat using decellularized spinach leaves

A research team has used spinach—a cost-effective and eco-friendly scaffold—as an edible platform to grow meat cells.

1 Apr 2021

Electron cryo-tomography reveals 3D images of sarcomeres at high resolution

Using electron cryo-tomography, researchers have created the first high-resolution 3D image of the sarcomere.

25 Mar 2021

Genetically engineered immune cells deliver anticancer signal to organs to prevent metastasis

Scientists have genetically engineered immune cells, called myeloid cells, to precisely deliver an anticancer signal to organs where cancer may spread.

25 Mar 2021

Stem cell therapy could help restore debilitating muscle loss that happens with age

As the name implies, induced pluripotent stem cells can become any type of cell in our body, and scientists have evidence that when they prompt them to become muscle progenitor cells they can help restore the sometimes debilitating muscle loss that happens with age.

24 Mar 2021

Study identifies a new mechanism that causes airway hyperresponsiveness in asthma

Asthma is a condition in which a person’s airways turn hyperresponsive.

15 Mar 2021

Catechin-type flavonoid compounds in tea relax blood vessels by activating ion channel proteins

A new study from the University of California, Irvine shows that compounds in both green and black tea relax blood vessels by activating ion channel proteins in the blood vessel wall.

9 Mar 2021

Study reveals new mechanism through which cells build “mini-muscles”

Research teams have revealed how the motor protein, called myosin, which is responsible for causing the contraction of skeletal muscles, also functions in non-muscle cells.

3 Mar 2021

High-fat diet may lead to greater risk of heart attacks

According to a study, consumption of a high-fat diet could trigger a response in the heart, causing growth and resulting in a higher risk of heart attacks.

3 Mar 2021

Almost one in five people lack key protein in their muscle fibers

About one in five individuals do not have the α-actinin-3 protein in their muscle fiber.

18 Feb 2021

Proprioceptive neurons perform sensory functions in all human body movements

Scientists have unveiled a range of proprioceptive neurons and have uncovered a new form of plasticity, indicating neuronal individuality in the nervous system.

16 Feb 2021

Researchers use unique methods to map the mechanism behind cellular communication

A better understanding of cellular interactions is crucial to interpret several biological diseases and systems.

15 Feb 2021

New AI-based method produces new diversity of AAV capsids for optimized gene therapy

Dyno Therapeutics has demonstrated the use of AI to created an unparalleled range of adeno-associated virus capsids that can evade the immune system.