Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

New model can help identify potential drug targets for ulcerative colitis

Scientists from the Lerner Research Institute at Cleveland Clinic have designed an innovative, patient-derived model of ulcerative colitis that will help scale up studies into new therapies for chronic inflammatory bowel disease.

12 Jan 2021

Researchers create 3D miniature organs that precisely mimic human tissues

Organoids are tissues that look like organs and are extracted from stem cells cultured in laboratories. They are usually known as miniature organs.

21 Dec 2020

Using genetic engineering to grow synthetic livers

News-Medical talks to Dr. Mo Ebrahimkhani about his research using genetic engineering together with a machine-learning algorithm to mature a lab-grown 'designer liver organoid'.

From University of Pittsburgh 15 Dec 2020

New breakthrough in microscopy and endoscopy may advance the field of precision medicine

A breakthrough in microscopy and endoscopy will soon revolutionize the study of the cellular origin of diseases, advancing the field of precision medicine.

3 Dec 2020

Teratomas could provide a new glance at human development

Finding just the right model to study human development--from the early embryonic stage onward--has been a challenge for scientists over the last decade.

From UC San Diego 5 Nov 2020

Researchers find genetic correlations between inflammatory bowel disease and stress, depression

Using sophisticated 3D genomic mapping and integrating with public data resulting from genome-wide association studies (GWAS), researchers at Children's Hospital of Philadelphia (CHOP) have found significant genetic correlations between inflammatory bowel disease (IBD) and stress and depression.

30 Oct 2020

Scientists develop lab-grown lung model to study SARS-CoV-2 infection

A team of Duke University researchers has developed a lab-grown living lung model that mimics the tiny air sacs of the lungs where coronavirus infection and serious lung damage take place. This advance has enabled them to watch the battle between the SARS-CoV-2 coronavirus and lung cells at the finest molecular scale.

23 Oct 2020

Researchers develop "mini lungs" to study SARS-CoV-2 infection

'Mini-lungs' grown from tissue donated to Cambridge hospitals has provided a team of scientists from South Korea and the UK with important insights into how COVID-19 damages the lungs.

23 Oct 2020

Synthetic signals could help control tissue regeneration

For a tiny embryo to develop into an adult organism, its cells must develop in precise patterns and interact with their neighbors in carefully orchestrated ways.

16 Oct 2020

Researchers uncover problems with the conventional method for growing organoids

Organoids are stem cell-based tissue surrogates that can mimic the structure and function of organs, and they have become a key component of numerous types of medical research in recent years.

1 Oct 2020

Researchers uncover tissue reparative role for a rare immune cell in the gut

Scientists from King's College London have discovered an unexpected tissue reparative role for a rare immune cell type in the gut that could tip toward fibrosis or cancer if dysregulated.

9 Sep 2020

New gene test predicts risk of drug-induced liver injury

Researchers who were exploring ways to establish the feasibility of batches of small liver organoids have now identified a new testing approach.

9 Sep 2020

Newly developed transplantable human cells can help cure type 1 diabetes

Researchers have made a significant advancement in the quest for a safe, effective treatment for type 1 diabetes.

20 Aug 2020

Deep Learning On Cell Signaling Networks Establishes AI For Single-Cell Biology

Computer systems that emulate key aspects of human problem solving are commonly referred to as AI. This field has seen massive progress over the last years.

6 Aug 2020

Study reveals key factor that influences malignant cells to develop into tumor

Researchers have unraveled a crucial factor that governs whether malignant cells will develop into a tumor. The study was recently published in the eLife journal.

22 Jul 2020

SOAT1 enzyme offers a promising therapeutic target for pancreatic cancer

Researchers from CSHL have discovered that the growth of pancreatic cancer cells can be stopped by disrupting the way cholesterol is stored by the cells.

8 Jul 2020

Organoids reveal inflammatory processes that play a role in infectious diseases

Research is employing mini-organs to model the digestive tract in the laboratory setting. These supposed organoids shed light on the inflammatory processes.

6 Jul 2020

Lab-grown 'mini-brains' can be infected by SARS-CoV-2 virus

A multidisciplinary team from two Johns Hopkins University institutions, including neurotoxicologists and virologists from the Bloomberg School of Public Health and infectious disease specialists from the school of medicine, has found that organoids (tiny tissue cultures made from human cells that simulate whole organs) known as "mini-brains" can be infected by the SARS-CoV-2 virus that causes COVID-19.

1 Jul 2020

Transcriptomic data can help track Neanderthal-derived RNA

Scientists are taking stem cell technology and using it to explore the developmental impacts of Neanderthal DNA.

19 Jun 2020

Cardiac organoids that closely mimic physiological conditions during a heart attack

In the U.S., someone has a heart attack every 40 seconds, and yet researchers have not had a model that fully mimics what occurs in the human heart after a heart attack.

12 Jun 2020